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Kosmas Daskalakis, Marina Tsoli, Anna Angelousi, Evanthia Kassi, Krystallenia I Alexandraki, Denise Kolomodi, Gregory Kaltsas and Anna Koumarianou

accurate pathologic and diagnostic tests, but also because of the increased awareness of these tumours by clinicians ( 1 ). NEN biology has also been clarified to some extent, paving the way for the development of novel molecular targeted therapies (MTTs

Open access

E T Aristizabal Prada and C J Auernhammer

disease of NETs of the GEP system ( 2 , 3 , 4 , 5 , 6 , 7 , 8 ), including molecular targeted therapy with the mammalian target of rapamycin (mTOR) inhibitor everolimus and the multi-tyrosinkinase inhibitor sunitinib, has significantly progressed

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Giulia Bresciani, Angeliki Ditsiou, Chiara Cilibrasi, Viviana Vella, Federico Rea, Marco Schiavon, Narciso Giorgio Cavallesco, Georgios Giamas, Maria Chiara Zatelli and Teresa Gagliano

surgery that is not feasible in most of the cases due to metastatic disease ( 6 , 9 , 10 ). Therefore, medical therapies, including chemotherapy, radiation, drugs acting on hormone receptors and molecular target therapy, gain a key role in the clinical

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Deborah Cosentini, Salvatore Grisanti, Alberto Dalla Volta, Marta Laganà, Chiara Fiorentini, Paola Perotti, Sandra Sigala and Alfredo Berruti

predisposing condition of response to immunotherapy. Moreover, there is an increasing interest in combining chemotherapy, radiotherapy or molecular target therapies with immunotherapy ( 28 , 29 ) and of course also agents inhibiting steroid synthesis may have

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Shan Wu, Jianjun Zhou, Jing Guo, Zhan Hua, Jianchen Li and Zai Wang

Oncology 2013 31 3219 – 3225 . ( https://doi.org/10.1200/JCO.2013.48.8585 ) 10.1200/JCO.2013.48.8585 7 Zhang H. Apatinib for molecular targeted therapy in tumor . Drug Design Development and Therapy 2015 9 6075 – 6081 . ( https://doi.org/10

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Sofia S Pereira, Mariana P Monteiro, Sonir R Antonini and Duarte Pignatelli

cancer . International Journal of Cell Biology 2010 2010 370835 . ( https://doi.org/10.1155/2010/370835 ) 20182539 9 Hassan M Watari H AbuAlmaaty A Ohba Y Sakuragi N . Apoptosis and molecular targeting therapy in cancer . BioMed Research