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Julia Otten Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Andreas Stomby Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Region Jönköping County, Jönköping, Sweden

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Maria Waling Department of Food, Nutrition and Culinary Science, Umeå University, Umeå, Sweden

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Elin Chorell Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Mats Ryberg Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Michael Svensson Department of Community Medicine and Rehabilitation, Section for Sports Medicine, Umeå University, Umeå Sweden

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Jens Juul Holst NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Tommy Olsson Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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or a Paleolithic diet combined with supervised exercise. At baseline and after 12 weeks of intervention, patients were examined with a solid mixed meal test, hyperinsulinemic-euglycemic clamping, and liver magnetic resonance spectroscopy. This paper

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0171
Volume/Issue:
Volume 10: Issue 9
Open access
Henri Honka Turku PET Centre, University of Turku, Turku, Finland

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Jukka Koffert Turku PET Centre, University of Turku, Turku, Finland
Department of Gastroenterology, Turku University Hospital, Turku, Finland

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Saila Kauhanen Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland

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Nobuyuki Kudomi Faculty of Medicine, Kagawa University, Kagawa, Japan

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Saija Hurme Department of Biostatistics, University of Turku, Turku, Finland

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Andrea Mari Institute of Neuroscience, National Research Council, Padua, Italy

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Andreas Lindqvist Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden

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Nils Wierup Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden

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Riitta Parkkola Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland

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Leif Groop Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden

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Pirjo Nuutila Turku PET Centre, University of Turku, Turku, Finland
Department of Endocrinology, Turku University Hospital, Turku, Finland

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nutrients and hormones secreted from the gut and pancreas elicit a shift in hepatic glucose metabolism toward net uptake ( 3 ). However, little is known about hepatic blood flow and volume (HBV) responses to a mixed-meal after bariatric surgery. The

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0234
Volume/Issue:
Volume 7: Issue 7
Open access
Jukka Koffert Department of Gastroenterology, Turunmaa Hospital, Turku, Finland
Turku PET Centre, University of Turku, Turku, Finland

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Henri Honka Turku PET Centre, University of Turku, Turku, Finland

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Jarmo Teuho Department of Gastroenterology, Turunmaa Hospital, Turku, Finland

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Saila Kauhanen Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland

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Saija Hurme Institute of Biostatistics, University of Turku, Turku, Finland

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Riitta Parkkola Turku PET Centre, University of Turku, Turku, Finland
Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland

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Vesa Oikonen Turku PET Centre, University of Turku, Turku, Finland

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Andrea Mari Institute of Neuroscience, National Research Council, Padua, Italy

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Andreas Lindqvist Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden

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Nils Wierup Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden

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Leif Groop Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden

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Pirjo Nuutila Turku PET Centre, University of Turku, Turku, Finland
Department of Endocrinology, Turku University Hospital, Turku, Finland

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intestinal and pancreatic BF and BV, respectively. The present study was conducted to evaluate the physiological vascular changes occurring in the gut and pancreas after a mixed-meal and after intravenous infusions GIP and GLP-1. Subjects and methods

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0015
Volume/Issue:
Volume 6: Issue 3
Open access
Marloes Emous Centre for Obesity Northern-Netherlands (CON), Medical Centre Leeuwarden, Leeuwarden, The Netherlands

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Merel van den Broek Centre for Obesity Northern-Netherlands (CON), Medical Centre Leeuwarden, Leeuwarden, The Netherlands

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Ragnhild B Wijma Centre for Obesity Northern-Netherlands (CON), Medical Centre Leeuwarden, Leeuwarden, The Netherlands

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Loek J M de Heide Centre for Obesity Northern-Netherlands (CON), Medical Centre Leeuwarden, Leeuwarden, The Netherlands

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Gertjan van Dijk GELIFES-Neurobiology, Department of Behavioral Neuroscience, University of Groningen, Groningen, The Netherlands

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Anke Laskewitz Certe Laboratories, Medical Center Leeuwarden, Leeuwarden, The Netherlands

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Erik Totté Centre for Obesity Northern-Netherlands (CON), Medical Centre Leeuwarden, Leeuwarden, The Netherlands

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Bruce H R Wolffenbuttel Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands

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André P van Beek Centre for Obesity Northern-Netherlands (CON), Medical Centre Leeuwarden, Leeuwarden, The Netherlands
Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands

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this is considered not physiological accurate; therefore, the mixed meal tolerance test (MMTT) is preferred ( 17 ). Smaller studies including up to ±20 patients using the MMTT after gastric bypass have been performed comparing patients with spontaneous

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0268
Volume/Issue:
Volume 8: Issue 7
Open access
Bjarke R Medici Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Birte Nygaard Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jeppe L la Cour Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark

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Martin Krakauer Department of Clinical Physiology and Nuclear Medicine, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark

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Andreas Brønden Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark

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Mette P Sonne Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark

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Jens J Holst Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jens F Rehfeld Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Tina Vilsbøll Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark

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Jens Faber Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Filip K Knop Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark

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, fasting (baseline) measurements (time points −30, −15, and −10 min) were conducted, including blood sampling, appetite evaluation, REE, and gallbladder volume measurement. At time point 0 min, participants ingested a liquid mixed meal (125 mL nutritional

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0314
Volume/Issue:
Volume 12: Issue 10
Open access
L Ahlkvist
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K Brown Department of Clinical Sciences, GlaxoSmithKline, Biomedical Center, C11, Lund University, SE 22184 Lund, Sweden

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B Ahrén
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(10 mg/kg) 10 min before a new gavage with the previously described mixed meal (11) . The dose of GSK706A was selected from initial experiments using both lower and higher doses (up to 30 mg/kg) with 10 mg/kg eliciting a maximal response in insulin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0079
Volume/Issue:
Volume 2: Issue 2
Open access
Jonathan Hazlehurst Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Bernard Khoo Endocrinology, Division of Medicine, University College London, London, UK

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Carolina Brito Lobato Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Medicine, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark

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Ibiyemi Ilesanmi Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK

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Sally Abbott Department of Dietetics, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Tin Chan Faculty of Medicine, Chinese University of Hong Kong, Hong Kong

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Sanesh Pillai Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Kate Maslin School of Nursing and Midwifery, University of Plymouth, Plymouth, UK

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Sanjay Purkayastha Brunel University, London, UK
Imperial College Healthcare NHS Trust, St Mary’s Hospital, London, UK

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Barbara McGowan Endocrinology, Guys’ and St Thomas’s NHS Foundation Trust, London, UK

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Rob Andrews University of Exeter Medical School, Exeter, UK

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Eveleigh Nicholson Portsmouth Hospitals University NHS Trust, Portsmouth, UK

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Katherine McCullough Royal Surrey County Hospital, Guildford, UK

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Lorraine Albon University Hospitals Sussex NHS Foundation Trust, Worthing, UK

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Rachel Batterham Endocrinology, Division of Medicine, University College London, London, UK

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Georgios K Dimitriadis King's College Hospital NHS Foundation Trust, London, UK

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Shareen Forbes BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Gavin Bewick School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK

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Tricia M-M Tan Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK

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.6 The efficacy and long-term effects of alternative approaches such as endoscopic revision of gastro-jejunal anastomoses (TORe). CGM, continuous glucose monitoring; GI, glycaemic index; MMT, mixed meal test; OGTT, oral glucose tolerance test

Article Type:
Other
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0285
Volume/Issue:
Volume 13: Issue 5
Open access
Annieke C G van Baar Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands

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Andrei Prodan Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands

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Camilla D Wahlgren Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark

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Steen S Poulsen Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Filip K Knop Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Albert K Groen Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
Department of Laboratory Medicine, University of Groningen, University Medical Center, Groningen, the Netherlands

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Jacques J Bergman Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands

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Max Nieuwdorp Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
Department of Internal Medicine, VUMC Free University, Amsterdam, the Netherlands
Wallenberg Laboratory, Sahlgrenska Hospital, University of Gothenburg, Gothenburg, Sweden

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Evgeni Levin Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
Horaizon BV, Delft, the Netherlands

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, enzymes, lipids, short-chain fatty acids, gut hormones, glycemic parameters and glucose regulatory hormones. In eligible subjects, a mixed meal test was conducted and on a separate day, a gastro-duodenoscopy was performed where duodenal biopsies were taken

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0094
Volume/Issue:
Volume 7: Issue 5
Open access
Leanne Hodson Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK

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Fredrik Karpe Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK

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extraction in the fasting state is up to 80% ( 7 , 8 , 9 ); after consumption of a mixed meal, portal vein insulin concentrations are approx. three times that in the systemic circulation ( 1 ). Peiris et al. ( 9 ) demonstrated that obese compared to non

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0350
Volume/Issue:
Volume 8: Issue 10
Open access
Metin Guclu Health Sciences University, Bursa Yuksek Ihtisas Education and Training Hospital, Department of Endocrinology and Metabolism, Bursa, Turkey

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Sinem Kiyici Health Sciences University, Bursa Yuksek Ihtisas Education and Training Hospital, Department of Endocrinology and Metabolism, Bursa, Turkey

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Zulfiye Gul Department of Pharmacology, Uludag University Medical Faculty, Bursa, Turkey

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Sinan Cavun Department of Pharmacology, Uludag University Medical Faculty, Bursa, Turkey

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suppression of serum ghrelin levels following a mixed meal test in obese diabetic women ( 10 ). However, there is no study evaluating the effects of chronic exenatide usage on serum fasting ghrelin levels. In the present study, we investigated the long

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0242
Volume/Issue:
Volume 7: Issue 1
Open access