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Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop-Schmenn, Nina Lass, Christina Bosse and Paul-Martin Holterhus

regulation of precursors of androgens and other steroid hormones within the steroid metabolome encompassing glucocorticoids, mineralocorticoids and estrogens is largely unknown in PCOS. Although PCOS has frequently been reported in adolescents, the

Open access

Aneta Gawlik, Michael Shmoish, Michaela F Hartmann, Stefan A Wudy, Zbigniew Olczak, Katarzyna Gruszczynska and Ze’ev Hochberg

-transformed concentrations of steroid metabolites (androgens, glucocorticoids and mineralocorticoids) in liver diseases (L1) and with non-liver disease features (L0) patients. Table 3 Ratio of steroid metabolites (enzyme activity): differences between patients

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Lukas Engler, Christian Adolf, Daniel A Heinrich, Anna-Katharine Brem, Anna Riester, Anna Franke, Felix Beuschlein, Martin Reincke, Axel Steiger and Heike Künzel

affected than males ( 1 ). These patients were also found to have a lower quality of life (QoL) even after treatment with either a mineralocorticoid receptor (MR) antagonist or adrenalectomy (ADX) ( 2 ). Cognitive deficits are prevalent in depression ( 3

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Tatiana V Novoselova, Peter J King, Leonardo Guasti, Louise A Metherell, Adrian J L Clark and Li F Chan

rare autosomal recessive condition clinically characterised by isolated glucocorticoid deficiency in the presence of normal mineralocorticoid function. FGD was first reported in two siblings diagnosed with Addison’s disease without hypoaldosteronism

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Marieke Stientje Velema, Aline de Nooijer, Ad R M M Hermus, Henri J L M Timmers, Jacques W M Lenders, Olga Husson and Jaap Deinum

unilateral aldosterone hypersecretion is suspected (APA), patients generally undergo adrenalectomy (ADX). Patients with BAH receive a mineralocorticoid receptor antagonist (MRA). Over the last decade, there has been increasing interest in the patient

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Frans H H Leenen, Mordecai P Blaustein and John M Hamlyn

, more slowly acting, signaling mechanism is also being activated that amplifies and maintains downstream responses. Several lines of evidence indicate that a slow-acting neuromodulatory pathway involving aldosterone, mineralocorticoid receptors (MR

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Hiren Patt, Katrin Koehler, Sailesh Lodha, Swati Jadhav, Chaitanya Yerawar, Angela Huebner, Kunal Thakkar, Sneha Arya, Sandhya Nair, Manjunath Goroshi, Hosahithlu Ganesh, Vijaya Sarathi, Anurag Lila, Tushar Bandgar and Nalini Shah

simultaneously elevated plasma adrenocorticotropic hormone (ACTH) (>2-fold above the upper limit of the reference interval for the specific assay) ( 7 ). Mineralocorticoid (MC) deficiency was defined as elevated (>upper limit of normal for age) plasma renin

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Lia Ferreira, João Silva, Susana Garrido, Carlos Bello, Diana Oliveira, Hélder Simões, Isabel Paiva, Joana Guimarães, Marta Ferreira, Teresa Pereira, Rita Bettencourt-Silva, Ana Filipa Martins, Tiago Silva, Vera Fernandes, Maria Lopes Pereira and Adrenal Tumors Study Group of the Portuguese Society of Endocrinology

, particularly regarding diagnosis, aetiology, concomitant autoimmune disorders, family history and replacement regimens, such as the type, daily dosage and dose frequency of glucocorticoids, as well as the use of mineralocorticoids. We assessed the occurrence of

Open access

Marianne Aa Grytaas, Kjersti Sellevåg, Hrafnkell B Thordarson, Eystein S Husebye, Kristian Løvås and Terje H Larsen

adrenalectomy in unilateral PA and medical treatment with mineralocorticoid receptor antagonists in bilateral PA. Several studies have demonstrated that PA patients have increased cardiovascular and renal morbidity compared with patients with essential HT ( 5

Open access

Yiyan Wang, Yaoyao Dong, Yinghui Fang, Yao Lv, Qiqi Zhu, Xiaoheng Li, Qingquan Lian and Ren-Shan Ge

cell lines or human and rat placentas. Moreover, HSD11B2 is thought to be the gate-keeper for the mineralocorticoid receptor in several target tissues, including the kidney and colon ( 37 ). Usually, mineralocorticoid receptors are without selectivity