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Anna-Pauliina Iivonen, Johanna Känsäkoski, Kirsi Vaaralahti and Taneli Raivio

heterogeneity, as to date over 30 genes underlying ncHH and KS have been identified ( 1 ). Several ncHH and KS disease genes are yet to be discovered, since currently known genes account for only half of all cases ( 1 ). miRNAs are small (~22 nt long) non

Open access

Devis Pascut, Sofia Tamini, Silvia Bresolin, Pablo Giraudi, Giuseppe Basso, Alessandro Minocci, Claudio Tiribelli, Graziano Grugni and Alessandro Sartorio

non-alcoholic fatty liver disease, both in children and adults, has been found in PWS ( 12 , 13 ). In recent years, growing evidences have identified miRNAs as important regulators of cellular pathways. They may affect lipid metabolism ( 14

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Marco Marino, Valentina Cirello, Valentina Gnarini, Carla Colombo, Elisa Pignatti, Livio Casarini, Chiara Diazzi, Vincenzo Rochira, Katia Cioni, Bruno Madeo, Cesare Carani, Manuela Simoni and Laura Fugazzola

diagnostic and prognostic molecular markers of PTC. In the last 8 years, studies on PTC have been focused on microRNAs (miRNAs), a class of endogenous, small noncoding RNA molecules that function as negative regulators of the expression of protein

Open access

Taís S Assmann, Mariana Recamonde-Mendoza, Bianca M De Souza and Daisy Crispim

with genetic and environmental risk factors ( 8 ). In this context, several microRNAs (miRNAs) are released in the circulation and might be used as biomarkers to evaluate health status and disease progression ( 2 ). miRNAs are a class of small

Open access

Elena Valassi, Natalia García-Giralt, Jorge Malouf, Iris Crespo, Jaume Llauger, Adolfo Díez-Pérez and Susan M Webb

strength index (a marker of cortical bone properties), as assessed using microindentation, and femoral cortical volumetric bone mineral density (vBMD) have been described in ACRO patients despite biochemical control of the disease ( 8 , 9 ). miRNAs are

Open access

T P McVeigh, R J Mulligan, U M McVeigh, P W Owens, N Miller, M Bell, F Sebag, C Guerin, D S Quill, J B Weidhaas, M J Kerin and A J Lowery

( 14 ). However, it is possible that this association may be explained by overlapping moderate- or low-penetrance breast-thyroid cancer genetic susceptibility loci ( 15 ). MicroRNAs (miRNAs) are crucial elements in the regulation of gene expression

Open access

Bingbing Wang, Mayra Cruz Ithier, Nataliya Parobchak, Stacy M Yadava, Jay Schulkin and Todd Rosen

of FlexiTube siRNAs target VDR or miRNA inhibitors as indicated (Qiagen) ( 19 , 20 ). Total RNAs were isolated from cells and analyzed by RT-qPCR. Each experiment was repeated in three individual specimens. Reverse transcription quantitative

Open access

K G Samsom, L M van Veenendaal, G D Valk, M R Vriens, M E T Tesselaar and J G van den Berg

– Ruebel et al. 2010 8 Primary and metastatic ileal NETs RT-PCR, miRNA expression assay, Northern blotting, in situ hybridisation Downregulation of miRNA-133a (ratio 0.27*), −145 (ratio 0.33*), −146 (ratio 0.36*), −222 (ratio 0.41*) and −10b

Open access

Maria Mizamtsidi, Constantinos Nastos, George Mastorakos, Roberto Dina, Ioannis Vassiliou, Maria Gazouli and Fausto Palazzo

✓ Growth factors VEGF ✓ ✓ ✓ FGF ✓ ✓ ✓ TGFB ✓ ✓ ✓ IGF-1 ✓ ✓ ✓ miRNA differential expression and parathyroid tumorigenesis MicroRNAs (miRNA) are small non-coding, single-stranded RNAs, 19

Open access

Kjell Oberg, Eric Krenning, Anders Sundin, Lisa Bodei, Mark Kidd, Margot Tesselaar, Valentina Ambrosini, Richard P Baum, Matthew Kulke, Marianne Pavel, Jaroslaw Cwikla, Ignat Drozdov, Massimo Falconi, Nicola Fazio, Andrea Frilling, Robert Jensen, Klaus Koopmans, Tiny Korse, Dik Kwekkeboom, Helmut Maecke, Giovanni Paganelli, Ramon Salazar, Stefano Severi, Jonathan Strosberg, Vikas Prasad, Aldo Scarpa, Ashley Grossman, Annemeik Walenkamp, Mauro Cives, Irene Virgolini, Andreas Kjaer and Irvin M Modlin

, and aggressiveness e.g., non-progressive vs malignant/metastatic) ( 41 , 42 ) and have demonstrable predictive utility at a tissue level ( 43 ). More recently, blood-based assays (CTCs, miRNA and circulating mRNA) have been developed. The most