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Pernille Bækgaard Udesen The Fertility Clinic, Department of Gynecology and Obstetrics, Zealand University Hospital, Køge, Denmark
Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Dorte Glintborg Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Anja Elaine Sørensen Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Rikke Svendsen Department of Science and Environment, Roskilde University, Roskilde, Denmark

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Nanna Louise Skov Nielsen Department of Science and Environment, Roskilde University, Roskilde, Denmark
Department of Clinical Immunology, Næstved Hospital, Næstved, Denmark

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Marie Louise Muff Wissing Aleris Hamlet Hospital Group, The Fertility Clinic, Søborg, Denmark

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Marianne Skovsager Andersen Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Anne Lis Mikkelsen Englund The Fertility Clinic, Department of Gynecology and Obstetrics, Zealand University Hospital, Køge, Denmark

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Louise Torp Dalgaard Department of Science and Environment, Roskilde University, Roskilde, Denmark

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well as many different miRNAs. Some of these miRNAs (e.g. miR-122, miR-223) are believed to have a more pronounced role than others, as several studies confirm their associations ( 15 , 16 ). miRNAs are produced in cells of various tissues and serve as

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Devis Pascut Fondazione Italiana Fegato – ONLUS, Trieste, Italy

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Sofia Tamini Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy

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Silvia Bresolin Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy

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Pablo Giraudi Fondazione Italiana Fegato – ONLUS, Trieste, Italy

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Giuseppe Basso Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy

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Alessandro Minocci Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy

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Claudio Tiribelli Fondazione Italiana Fegato – ONLUS, Trieste, Italy

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Graziano Grugni Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy

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Alessandro Sartorio Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy

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10% top expressed circulating miRNome with a log2 fold change (FC) greater than 5 (Supplementary Table 4). Among the highly expressed miRNA in serum, miR-92a-3p, mir-122, miR-185-5p, 191-5p were implicated in lipid metabolism and their association

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Elena Valassi Endocrinology/Medicine Department, Hospital Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Natalia García-Giralt URFOA, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Universitat Autònoma de Barcelona, Barcelona, Spain

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Jorge Malouf Mineral Metabolism Unit, Medicine Department, Hospital Sant Pau, Barcelona, Spain

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Iris Crespo Endocrinology/Medicine Department, Hospital Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Jaume Llauger Radiology Department, Hospital Sant Pau, Barcelona, Spain

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Adolfo Díez-Pérez URFOA, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Universitat Autònoma de Barcelona, Barcelona, Spain

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Susan M Webb Endocrinology/Medicine Department, Hospital Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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.006 −1.88 ± 0.008 −1.2 0.17 0.35 hsa-miR-324-5p −0.44 ± 0.008 −4.77 ± 0.008 1.23 0.17 0.35 hsa-miR-29a-3p −2.65 ± 0.006 −2.43 ± 0.007 −1.16 0.23 0.43 hsa-miR-122-5p −1.88 ± 1.02 −0.15 ± 0.13 −0.12 0

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Stephen J Winters Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, Kentucky, USA

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Charles R Scoggins Division of Surgical Oncology, University of Louisville, Louisville, Kentucky, USA

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Duke Appiah Department of Public Health, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

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Dushan T Ghooray Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, Kentucky, USA

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.127274 ) 45 Li M Tang Y Wu L Mo F Wang X Li H Qi R Zhang H Srivastava A Ling C The hepatocyte-specific HNF4α/miR-122 pathway contributes to iron overload-mediated hepatic inflammation . Blood 2017 130 1041 – 1051 . ( https

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