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Erika Urbano Lima, Ileana G S Rubio, Joaquim Custodio Da Silva, Ana Luiza Galrão, Danielle Pêssoa, Taise Cerqueira Oliveira, Fabiane Carrijo, Igor Silva Campos, Luciano Fonseca Espinheira, Luiz Jose Sampaio, Claudio Rogerio Lima, Janete Maria Cerutti and Helton Estrela Ramos

affected by a growing number of DNA alterations in tumor-suppressor genes, especially via gene promoter methylation ( 4 ) causing a silencing of tumor-suppressor genes that are linked to apoptosis or DNA repair ( 5 , 6 ). A better understanding of such

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Tingting Xia, Hongru Sun, Hao Huang, Haoran Bi, Rui Pu, Lei Zhang, Yuanyuan Zhang, Ying Liu, Jing Xu, Justina Ucheojor Onwuka, Yupeng Liu, Binbin Cui and Yashuang Zhao

methylation ( 8 ). Additionally, methylation of HpaII and HhaI sites near the polymorphic CAG repeats was reported in the human AR gene ( 9 ). Research has revealed that the development of CRCs is due to multistep processes as a consequence of the

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Jairo Arturo Pinzón-Cortés, Angelina Perna-Chaux, Nicolás Steven Rojas-Villamizar, Angélica Díaz-Basabe, Diana Carolina Polanía-Villanueva, María Fernanda Jácome, Carlos Olimpo Mendivil, Helena Groot and Valeriano López-Segura

carry epigenetic changes that persist for many years and predispose them to developing complications ( 9 , 11 , 12 , 13 ). Several studies in patients with T2DM have found changes in the genome methylation profile, such as a reduced level of DNA

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Roberto Cosimo Melcangi, Livio Casarini, Marco Marino, Daniele Santi, Samantha Sperduti, Silvia Giatti, Silvia Diviccaro, Maria Grimoldi, Donatella Caruso, Guido Cavaletti and Manuela Simoni

associated with inflammation and depression ( 29 , 30 ), features that, as mentioned earlier, have been also observed in PFS model ( 28 ). In this setting, the evaluation of the methylation pattern remains challenging since it could change during adulthood

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Elham Barazeghi, Per Hellman, Gunnar Westin and Peter Stålberg

tumors ( 4 ). Promoter DNA methylation studies revealed increased RASSF1A / CTNNB1 methylation associated with metastatic progression, and epigenetic repression of TCEB3C in SI-NETs ( 5 , 6 ). A comprehensive integrated molecular analysis of a large

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K L Gatford, G K Heinemann, S D Thompson, J V Zhang, S Buckberry, J A Owens, G A Dekker, C T Roberts and on behalf of the SCOPE Consortium

locus, who therefore express maternal and paternal IGF2 alleles, often have pre- and postnatal overgrowth, suggesting increased IGF2 availability (reviewed by (40) ). This suggests that SNPs associated with altered DNA methylation at this locus may

Open access

Djeda Belharazem, Matthias Kirchner, Franziska Geissler, Peter Bugert, Martin Spahn, Burkhard Kneitz, Hubertus Riedmiller, Christian Sauer, Stefan Küffer, Lutz Trojan, Christian Bolenz, Maurice Stephan Michel, Alexander Marx and Philipp Ströbel

(e.g. methylation) that usually allow expression of only one allele in a parent-of-origin-dependent fashion (6) . Loss of imprinting (LOI) is considered one of the earliest (7) and most abundant alterations in cancer (8) . Among the 90 imprinted

Open access

K G Samsom, L M van Veenendaal, G D Valk, M R Vriens, M E T Tesselaar and J G van den Berg

((((((((((genom*[Title/Abstract]) OR epigenetic*[Title/Abstract]) OR gene*[Title/Abstract]) OR exom*[Title/Abstract]) OR chromosom*[Title/Abstract]) OR molecular*[Title/Abstract]) OR allel*[Title/Abstract])) OR sequenc*[Title/Abstract]) OR (((((methylation

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Nancy J Olsen, Ann L Benko and William J Kovacs

medications at the time of entry into the study. Androgen receptor CAG repeat genotyping, AR gene methylation analysis, and calculation of weighted AR CAG repeat length Genomic DNA was isolated from peripheral whole blood or from buffy coat cells using the

Open access

Magnolia Ariza-Nieto, Joshua B Alley, Sanjay Samy, Laura Fitzgerald, Francoise Vermeylen, Michael L Shuler and José O Alemán

methylation-susceptible CpG islands in their promoter regions, and for that they are known to form regulatory loops with DNMT1 in cancer tissue and cancer cell lines in vitro ( 17 ). In adipocytes, DNMT1 contributes to the expression of adiponectin ( 18