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filtration system. On the other hand, the non-invasive collection of urine is conducive to many metabolomic applications. Metabolomics enables the systematic assessment of the abundant changes of low-molecular-weight compounds present in biological samples
Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China
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, physical activity has shown a reduction in diabetes and cardiovascular diseases (35 and 49%, respectively) among NAFLD patients ( 5 , 6 ). Metabolomics is a high-throughput technology that can measure thousands of metabolites (in biological fluids or
Department of Endocrinology, Department of Molecular Medicine and Surgery, Metabolism and Diabetology, Karolinska University Hospital, 171 76 Stockholm, Sweden
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Introduction Metabolomics is an exciting new analytical field in systems biology, which uses techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy to define the pattern of low-molecular weight compounds (LMCs
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, imaging markers, and even genetic markers, providing valuable insights into the disease's pathology ( 12 , 13 , 14 ). In recent years, metabolomics, an emerging field of ‘omics’ research, has shown great promise in identifying novel biomarkers for
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mainly focused on the exploration of upstream genomics, transcriptomics, and proteomics. The recent application of metabolomics in medical research has enabled the development of metabolic biomarkers and the elucidation of physiological mechanisms
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subject’s unique metabolic fingerprint and offers means of metabolomic phenotyping at the individual level ( 9 , 10 ). Thus, each individual has a unique ‘steroidal fingerprint’. A cluster of similar ‘steroidal fingerprints’ related to a disease would be
eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA
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eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA
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eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA
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eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA
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. Metabolomics, or the study of small molecules in biological samples, is a powerful tool to inform metabolic processes in disease states. Metabolomics is a comprehensive approach to assessing systems biology, encompassing both endogenous metabolic processes and
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. The sequence of gene primers is shown in Supplementary Table 2. All experiments were performed in triplicate. Relative quantitative expression levels were calculated using the 2 −∆∆ Ct method. Collection of serum samples and metabolomic
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Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA
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Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA
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Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA
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adipogenesis. To probe these and other possible modes of action including disruption of 5-HT production and placental inflammation, we employed a diverse range of hypothesis-generating (RNA sequencing and untargeted metabolomics) and targeted (quantitative real
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further analyze the liver situation of congenital IGHD patients. Metabolomics has been used in the comprehensive profiling of small molecular metabolites (<1 kDa) in cells, tissues, and whole organisms ( 7 ). It has been roughly divided into targeted