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Min Li, Ying Chen, Jingjing Jiang, Yan Lu, Zhiyi Song, Shengjie Zhang, Chao Sun, Hao Ying, Xiaofang Fan, Yuping Song, Jialin Yang and Lin Zhao

Introduction Thyroid hormone (TH) is required for both normal development and metabolism ( 1 , 2 ), acting through its two receptor isoforms, α and β. TRα is mainly expressed in the skeletal muscle, adipose tissue and heart, whereas TRβ is

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Karim Gariani, Geneviève Drifte, Irène Dunn-Siegrist, Jérôme Pugin and François R Jornayvaz

-activated receptor α (PPARα) and PPARγ respectively (1, 6) . FGF21 has emerged as a key regulator in the metabolism of glucose and lipids (6, 7, 8) . FGF21 may have a potential role as a therapeutic agent for conditions associated with insulin resistance as it has

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L Johnsen, N B Lyckegaard, P Khanal, B Quistorff, K Raun and M O Nielsen

development and maturation, in regulation of metabolism through stimulation of mitochondrial oxygen consumption, carbohydrate and lipid metabolism, and it affects functional development of the nervous and cardiovascular systems ( 13 , 14 ). As summarized in

Open access

Nese Cinar and Alper Gurlek

obesity, dyslipidemia, type 2 diabetes, hypertension, and cardiovascular complications, by promoting a low-grade WAT inflammation (1, 2) . Thyroid hormones are involved in the regulation of body metabolism. Their effects include the stimulation of resting

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Janaína Felix Braga, Daniela Ravizzoni Dartora, Natalia Alenina, Michael Bader and Robson Augusto Souza Santos

Introduction Besides its role in the regulation of blood pressure and the cardiovascular system, the renin–angiotensin system (RAS) plays an important role in the control of glucose and lipid metabolism ( 1 ). Moreover, it is a determinant in

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Athanasios D Anastasilakis, Marina Tsoli, Gregory Kaltsas and Polyzois Makras

lesional and systemic alterations of factors involved in bone metabolism, and the potential therapeutic implications for both bone and multisystem LCH management. LCH pathogenesis LCH is characterized by clonal proliferation and dissemination of

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Mohammed S Albreiki, Benita Middleton and Shelagh M Hampton

and glucose metabolism, such as glucose-6-phosphate dehydrogenase ( 7 , 8 ). Therefore, disruption of circadian coordination may be manifested by endocrine imbalances ( 9 ), incidence of obesity ( 10 ) and type 2 diabetes ( 11 , 12 ). This raises a

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Kaisa K Ivaska, Maikki K Heliövaara, Pertti Ebeling, Marco Bucci, Ville Huovinen, H Kalervo Väänänen, Pirjo Nuutila and Heikki A Koistinen

Introduction Bone is increasingly recognized as an effector in energy metabolism via its interactions with other tissues (1, 2) . The role of bone-derived osteocalcin (OC) as a novel endocrine regulator of glucose and lipid metabolism was

Open access

Thiago U Pantaleão, Andrea C F Ferreira, Maria C S Santos, Álvaro S P Figueiredo, Ruy A N Louzada, Doris Rosenthal, Denise P Carvalho and Vânia M Corrêa da Costa

important deleterious effects on central nervous system. In the brain, most nuclear triiodothyronine (T 3 ) is locally produced from the prohormone thyroxine (T 4 ) by type 2 iodothyronine deiodinase (D2) ( 5 ). Since deiodinases regulate the metabolism of

Open access

Nicolai Preisler, Pascal Laforêt, Karen Lindhardt Madsen, Edith Husu, Christoffer Rasmus Vissing, Gitte Hedermann, Henrik Galbo, Christopher Lindberg and John Vissing

during prolonged (i.e. 1 h) moderate intensity exercise, in patients with Pompe disease. We used cycle-ergometer exercise and stable isotope methodology in combination with indirect calorimetry to determine glucose, glycerol, and fatty acid metabolism