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Trevor Lewis, Eva Zeisig and Jamie E Gaida

Introduction The mechanisms linking obesity and poor metabolic health to increased tendinopathy risk remain unclear ( 1 ). Among athletes, mechanical load associated with high training volumes and hard training surface can trigger tendinopathy

Open access

Leanne Hodson and Fredrik Karpe

– 1903. ( https://doi.org/10.2337/db12-1407 ) 23349503 79 Piche ME Parry SA Karpe F Hodson L . Chylomicron-derived fatty acid spillover in adipose tissue: a signature of metabolic health? Journal of Clinical Endocrinology & Metabolism 2018

Open access

Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen and Anders Juul

Introduction

Bisphenol A and several of the most commonly used phthalates have been associated with adverse metabolic health effects such as obesity and diabetes. Therefore, we analyzed these man-made chemicals in first morning urine samples from 107 healthy normal-weight Danish children and adolescents.

Method

This was a cross-sectional study. Participants were recruited as part of the Copenhagen Puberty Study. The subjects were evaluated by an oral glucose tolerance test (OGTT), a dual-energy X-ray absorptiometry (DXA) scan, direct oxygen uptake measurement during cycle ergometry and fasting blood samples. First morning urine was collected and phthalate metabolites and BPA were measured by liquid chromatography-tandem mass spectrometry (LC–MS/MS) with prior enzymatic deconjugation. Individual chemical concentrations were divided into tertiles and analyzed in relation to biological outcome.

Results

Children in the lowest tertile of urinary BPA had significantly higher peak insulin levels during OGTT (P = 0.01), lower insulin sensitivity index (P < 0.01), higher leptin (P = 0.03), triglyceride (P < 0.01) and total cholesterol levels (P = 0.04), lower aerobic fitness (P = 0.02) and a tendency toward higher fat mass index (P = 0.1) compared with children in the highest tertile for uBPA. No significant differences in anthropometrics, body composition or glucose metabolism were associated with any of the phthalate metabolites measured.

Conclusion

This pilot study on healthy normal-weight children suggests an inverse association between BPA and insulin resistance. Our findings contrast other cross-sectional studies showing a positive association for BPA, which may be due to confounding or reverse causation because diet is an important source of both BPA exposure and obesity.

Open access

Shane M Regnier, Andrew G Kirkley, Daniel Ruiz, Wakanene Kamau, Qian Wu, Kurunthachalam Kannan and Robert M Sargis

Introduction Global metabolic health has deteriorated dramatically over the last several decades with the emergence of the obesity and diabetes epidemics. Nearly 69% of the U.S. population is now overweight, with 35% currently obese ( 1 ) and

Open access

Magnolia Ariza-Nieto, Joshua B Alley, Sanjay Samy, Laura Fitzgerald, Francoise Vermeylen, Michael L Shuler and José O Alemán

metabolic surgery, making it an attractive candidate for neoadjuvant weight loss treatment leading to improved metabolic health. Our preliminary data suggest this method will allow early diagnosis, as well as the monitoring of interventions, aim for the

Open access

A C Paepegaey, M Coupaye, A Jaziri, F Ménesguen, B Dubern, M Polak, J M Oppert, M Tauber, G Pinto and C Poitou

treatment does not appear to adversely affect the metabolic health profile ( 35 ). Thus, the maintenance of GH treatment in adulthood is justified in those who benefit from GH treatment in childhood. Surprisingly, transitional care was not associated with a

Open access

Selina Mäkinen, Yen H Nguyen, Paulina Skrobuk and Heikki A Koistinen

robust. Interestingly, several in vivo studies have provided compelling evidence that substituting saturated fat for mono- and polyunsaturated fatty acids improves metabolic health and protects against coronary artery disease ( 7 , 8 , 9 , 10 , 19

Open access

M A Webb, H Mani, S J Robertson, H L Waller, D R Webb, C L Edwardson, D H Bodicoat, T Yates, K Khunti and M J Davies

daily step count can have a significant positive impact on the metabolic health of overweight women with PCOS. Subjects and methods The current study is a secondary analysis of the Structured Education Programme to Improve Cardiovascular Risk in

Open access

Michaela Keuper

.1152/ajpendo.00586.2009) 122 Phillips CM Perry IJ . Does inflammation determine metabolic health status in obese and nonobese adults? Journal of Clinical Endocrinology and Metabolism 2013 98 E1610 – E1619 . ( https://doi.org/10.1210/jc.2013

Open access

Søs Dragsbæk Larsen, Christine Dalgård, Mathilde Egelund Christensen, Sine Lykkedegn, Louise Bjørkholt Andersen, Marianne Andersen, Dorte Glintborg and Henrik Thybo Christesen

cardio-metabolic health at 20 years: a prospective cohort study over two decades . PLoS ONE 2016 11 e0164758 . ( https://doi.org/10.1371/journal.pone.0164758 ) 18 Kyhl HB Jensen TK Barington T Buhl S Norberg LA Jorgensen JS Jensen DF Christesen