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W Liu, Y Wang, X Han, X Cai, Y Zhu, M Zhang, S Gong, J Li and L Ji

of the longevity of T1DM patients. ( 8 , 9 ) These findings suggest that individuals with an extremely long duration of T1DM are either protected from or show slower progression of diabetic microvascular complications. This survival bias inherent in

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Ananda A Santana-Ribeiro, Giulliani A Moreira-Brasileiro, Manuel H Aguiar-Oliveira, Roberto Salvatori, Vitor O Carvalho, Claudia K Alvim-Pereira, Carlos R Araújo-Daniel, Júlia G Reis-Costa, Alana L Andrade-Guimarães, Alécia A Oliveira-Santos, Edgar R Vieira and Miburge B Gois-Junior

, farming and domestic work ( 13 ). Although these subjects report higher prevalence of dizziness ( 14 ), they are not prone to fractures even at advanced ages ( 15 ). They also have normal quality of life ( 16 ) and longevity ( 17 ). Recently, we have shown

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Rachel D C A Diniz, Renata M Souza, Roberto Salvatori, Alex Franca, Elenilde Gomes-Santos, Thiago O Ferrão, Carla R P Oliveira, João A M Santana, Francisco A Pereira, Rita A A Barbosa, Anita H O Souza, Rossana M C Pereira, Alécia A Oliveira-Santos, Allysson M P Silva, Francisco J Santana-Júnior, Eugênia H O Valença, Viviane C Campos and Manuel H Aguiar-Oliveira

-C and high C-reactive protein) (17, 18) , they have increased insulin sensitivity (19) , high adiponectin and normal leptin serum levels (20) , no evidence of premature atherosclerosis (21) , and normal longevity (22) . As NAFLD is related to

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Ursula M M Costa, Carla R P Oliveira, Roberto Salvatori, José A S Barreto-Filho, Viviane C Campos, Francielle T Oliveira, Ivina E S Rocha, Joselina L M Oliveira, Wersley A Silva and Manuel H Aguiar-Oliveira

) and increased insulin sensitivity (14) . The adult IGHD individuals do not present premature clinical carotid (15) or aortic atherosclerosis (16) nor coronary ischemia assessed by stress echocardiography (15, 17) , and have similar longevity as

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Ferdinand Roelfsema, Diana van Heemst, Ali Iranmanesh, Paul Takahashi, Rebecca Yang and Johannes D Veldhuis

. Subjects and methods Clinical protocol The 109 volunteers from Leiden, The Netherlands, had participated as controls in studies on neurological disorders, obesity, longevity and ACTH–cortisol relationships ( 3 , 4 , 9 , 21 ). In addition, 34

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K L Gatford, G K Heinemann, S D Thompson, J V Zhang, S Buckberry, J A Owens, G A Dekker, C T Roberts and on behalf of the SCOPE Consortium

(28, 29, 30) , but not all, studies (31, 32) , with lower plasma IGF1 concentrations also reported in AG heterozygotes (28) . The AA genotype also predicts increased longevity (28, 29, 30) , and shorter male adult height (33) , consistent with

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Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante, Giustino Orlando, Michele Vacca, Roberto Salvatori and Luigi Brunetti

in brain microvascular density, resulting in decreased cerebral blood flow ( 4 ). Recent studies have demonstrated an important role of the IGF-1 and insulin-related signalling pathways in the control of longevity in mice ( 6 ). Indeed, GH

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Taísa A R Vicente, Ívina E S Rocha, Roberto Salvatori, Carla R P Oliveira, Rossana M C Pereira, Anita H O Souza, Viviane C Campos, Elenilde G Santos, Rachel D C Araújo Diniz, Eugênia H O Valença, Carlos C Epitácio-Pereira, Mario C P Oliveira, Andrea Mari and Manuel H Aguiar-Oliveira

(10) , resulting in severe proportionate dwarfism. Despite several cardiovascular risk factors (11) , they exhibit normal longevity (12) and no evidence of premature atherosclerosis (13) . We have recently studied 24 IGHD subjects and found that

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Li Jing and Wang Chengji

oxidative stress and inflammation in aging and cardiovascular diseases . Oxidative Medicine and Cellular Longevity 2016 2016 7239639 . ( ) 26823952 6 Sarzynski MA Burton J Rankinen T Blair SN Church TS Després J

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Christin Krause, Martina Grohs, Alexander T El Gammal, Stefan Wolter, Hendrik Lehnert, Oliver Mann, Jens Mittag and Henriette Kirchner

with longevity ( 33 ). Moreover, older adults show a prevalence for subclinical hypothyroidism, but it is currently highly controversial whether a treatment is beneficial or harmful ( 34 ). Consequently, data on the local change in TH economy on the