the number of arm entries per trial was used to indicate memory acquisition. Locomotor activity/open field test Locomotor activity was recorded in the home cage over 10 min by a video camera (SSC-DC378P, Biosite, Stockholm, Sweden) positioned
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Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante, Giustino Orlando, Michele Vacca, Roberto Salvatori, and Luigi Brunetti
Henryk F Urbanski, Kevin Mueller, and Cynthia L Bethea
Like women, old female rhesus macaques undergo menopause and show many of the same age-associated changes, including perturbed activity/rest cycles and altered circulating levels of many hormones. Previous studies showed that administration of an estrogen agonist increased activity in female monkeys, that hormone therapy (HT) increased activity in postmenopausal women and that obesity decreased activity in women. The present study sought to determine if postmenopausal activity and circulating hormone levels also respond to HT when monkeys are fed a high-fat, high-sugar Western style diet (WSD). Old female rhesus macaques were ovo-hysterectomized (OvH) to induce surgical menopause and fed a WSD for 2 years. Half of the animals received estradiol-17β (E), beginning immediately after OvH, while the other half received placebo. Animals in both groups showed an increase in body weight and a decrease in overall activity levels. These changes were associated with a rise in both daytime and nocturnal serum leptin concentrations, but there was no change in serum concentrations of either cortisol or dehydroepiandrosterone sulfate (DHEAS). These data suggest that 2 years of HT has little or no effect on locomotor activity or circadian hormone patterns in menopausal macaques fed an obesogenic diet.
Stephen A Martin, Kenneth A Philbrick, Carmen P Wong, Dawn A Olson, Adam J Branscum, Donald B Jump, Charles K Marik, Jonathan M DenHerder, Jennifer L Sargent, Russell T Turner, and Urszula T Iwaniec
facultative daily heterotherms and experience fasting-induced decreases in body temperature upon exposure to temperatures below their thermoneutral zone (26–34°C) ( 8 ). During the light photoperiod, when food intake and locomotor activity are reduced
Shuhui Ma, Zixu Wang, Jing Cao, Yulan Dong, and Yaoxing Chen
plays an important role in the circadian and seasonal rhythms, immunomodulation and neurotransmission ( 3 ). In birds, pinealectomy abolished the circadian patterns of locomotor activity and body temperature ( 4 , 5 ), which was attributed to the
Gavin P Vinson and Caroline H Brennan
-induced locomotor activity was unaffected in Crh1 knockouts or by the antagonist CP 154 526 in DBA/2J mice, whereas deletion of Crh2 attenuated MA-induced behavioural sensitization. Here, an action of endogenous urocortins was suggested, focused in the
Huifei Sophia Zheng, Jeffrey G Daniel, Julia M Salamat, Laci Mackay, Chad D Foradori, Robert J Kemppainen, Satyanarayana R Pondugula, Ya-Xiong Tao, and Chen-Che Jeff Huang
dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats . Neuropsychopharmacology 2005 30 1617 – 1623 . ( https://doi.org/10.1038/sj.npp.1300716 ) 10
Rajae Talbi and Victor M Navarro
independent of the presence of circulating sex steroids. Adult Kiss1r KO females, but not males, displayed decreased food intake but higher body weight as a consequence of reduced energy expenditure and locomotor activity, as well as impaired glucose
Carolina Inda, Natalia G Armando, Paula A dos Santos Claro, and Susana Silberstein
M Thatcher-Britton K Rivier J Vale W Koob GF. Effects of corticotropin releasing factor on locomotor activity in hypophysectomized rats . Peptides 1985 6 923 – 926 . ( doi:10.1016/0196-9781(85)90323-7 ) 20 Henckens MJ
