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C Sui, Q He, R Du, D Zhang, F Li, G Dionigi, N Liang and H Sun

Introduction According to the current 8th edition of the American Joint Committee on Cancer staging system, the N stage in TC is determined by the location of positive LNs, and other LNs features (i.e., the number of positive LNs, number of

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Kranti Khadilkar, Vijaya Sarathi, Rajeev Kasaliwal, Reshma Pandit, Manjunath Goroshi, Gaurav Malhotra, Abhay Dalvi, Ganesh Bakshi, Anil Bhansali, Rajesh Rajput, Vyankatesh Shivane, Anurag Lila, Tushar Bandgar and Nalini S Shah

have suggested size (greater than 5 cm), location (sympathetic PGL) of the primary tumour, tumour necrosis, non-secretory status and dopamine secretion as clinical predictors of metastatic disease in PCC/PGL ( 10 , 11 , 12 , 13 , 14 ). Multiple

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Roxanne C S van Adrichem, Aart Jan van der Lely, Martin Huisman, Piet Kramer, Richard A Feelders, Patric J D Delhanty and Wouter W de Herder

) and clinical parameters (age at diagnosis, sex, primary tumor location, carcinoid syndrome, ENETS TNM classification ( 32 , 33 ), Ki-67 proliferation index, grading, prior incomplete surgery) in NET patients. Subjects and methods NET

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Lesley A Hill, Zeynep Sumer-Bayraktar, John G Lewis, Eva Morava, Morten Thaysen-Andersen and Geoffrey L Hammond

that some CBG glycoforms bind steroid with abnormally low affinity, which is a possibility because the presence and composition of N -glycans at specific locations on the CBG molecule influence its steroid-binding properties ( 12 , 25 ). Interestingly

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Darling M Rojas-Canales, Michaela Waibel, Aurelien Forget, Daniella Penko, Jodie Nitschke, Fran J Harding, Bahman Delalat, Anton Blencowe, Thomas Loudovaris, Shane T Grey, Helen E Thomas, Thomas W H Kay, Chris J Drogemuller, Nicolas H Voelcker and Patrick T Coates

Islet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islets are still lost in the pre-transplant period, limiting the success of this treatment. Moreover, current practice includes islets being prepared at specialized centers, which are sometimes remote to the transplant location. Thus, a critical point of intervention to maintain the quality and quantity of isolated islets is during transportation between isolation centers and the transplanting hospitals, during which 20–40% of functional islets can be lost. The current study investigated the use of an oxygen-permeable PDMS microwell device for long-distance transportation of isolated islets. We demonstrate that the microwell device protected islets from aggregation during transport, maintaining viability and average islet size during shipping.

Open access

Yuan Zhou, ShengNan Wang, Jing Wu, Jianjun Dong and Lin Liao

Aims: Heterozygous inactivating mutations in the GCK gene cause the familial, mild fasting hyperglycaemia named MODY2. Many patients with MODY2 in Asia have delayed timely treatment because they did not receive the correct diagnosis. This study aims to analyze the clinical characteristics and GCK mutations in Asian MODY2.

Methods: We have collected 110 Asian patients with MODY2 from the Pubmed, Embase, Medline, Web of Science, CNKI, and Wanfang with the following search terms: "Maturity-Onset Diabetes of the Young" OR "MODY" OR "Maturity-Onset Diabetes of the Young type 2" OR "MODY2" OR "GCK-DM" OR "GCK-MODY". Both mutations of GCK and clinical characteristics of MODY2 were analyzed.

Results: There were 96 different mutations occurred in coding regions and non-coding regions. Exon 5 and 7 were the most common location in coding regions, and missense was the primarily mutation type. The proportion of probands younger than 25 was 81.8%, and 81.4% of the probands had family history of hyperglycaemia. Ninety percent and 93% of Asian MODY2 probands exhibited the mild elevating in FPG (5.4-8.3 mmol/L) and HbA1c (5.6-7.6%), respectively.

Conclusions: Most Asian MODY2 patients were due to GCK mutation in coding region, and exon 5 and 7 were the most common locations. FPG, HbA1c, and familial diabetes were important reference indicators for diagnosing MODY2. Altogether, the study indicates that for the young onset of diabetes with mild elevated blood glucose and HbA1c, and family history of hyperglycaemia, molecular genetic testing is suggested in order to differ MODY2 from other types of diabetes earlier.

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Susanna Cirera, Sophia G Moesgaard, Nora E Zois, Nathja Ravn, Jens P Goetze, Signe E Cremer, Tom Teerlink, Páll S Leifsson, Jesper L Honge, J Michael Hasenkam and Lisbeth H Olsen

) and echocardiographic markers (MR and LVIDD) and mRNA markers. Linear mixed effects models were used to evaluate the influence of heart locations (MV, LV, and AP) and experimental groups (CON, mild MR (mMR), and moderate/severe MR (sMR)) on the

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Małgorzata Fuksiewicz, Maria Kowalska, Agnieszka Kolasińska-Ćwikła, Jarosław B Ćwikła, Łukasz Sawicki, Katarzyna Roszkowska-Purska, Joanna Drygiel and Beata Kotowicz

indicate some relationships between the degree of differentiation of NENs, the location of a primary lesion, the tumour mass and CgA levels ( 4 , 5 , 6 , 7 ). Recent research confirms that CgA plays an important role in the regulation of angiogenesis, as

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Laura J Reid, Bala Muthukrishnan, Dilip Patel, Mike S Crane, Murat Akyol, Andrew Thomson, Jonathan R Seckl and Fraser W Gibb

component of concomitant 99m Tc-sestamibi SPECT CT imaging. Planar 99m Tc-sestamibi and 99m Tc-sestamibi SPECT were considered as a single entity for data analysis. In cases with surgically confirmed adenoma/hyperplasia location data, the accuracy of

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W Liu, Y Wang, X Han, X Cai, Y Zhu, M Zhang, S Gong, J Li and L Ji

. Factors associated with DN In the multivariable regression analysis, which was adjusted for HbA1c and LDL-C, urban/rural background, and SBP maintained their associations with DN. The OR (95% CI) for birth in a rural location was 4.76 (1.82, 8