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Magaly Zappa, Olivia Hentic, Marie-Pierre Vullierme, Matthieu Lagadec, Maxime Ronot, Philippe Ruszniewski and Valérie Vilgrain

grouped as gastroenteropancreatic neuroendocrine tumours, or GEP-NETs. They are frequently metastasised at diagnosis, and the liver is the most common site of metastases ( 1 ). The presence of liver metastases is a significant negative prognostic factor

Open access

Myrtille Fouché, Yves Bouffard, Mary-Charlotte Le Goff, Johanne Prothet, François Malavieille, Pierre Sagnard, Françoise Christin, Davy Hayi-Slayman, Arnaud Pasquer, Gilles Poncet, Thomas Walter and Thomas Rimmelé

Only few descriptions of intraoperative carcinoid syndrome (ioCS) have been reported. The primary objective of this study was to describe ioCS. A second aim was to identify risk factors of ioCS. We retrospectively analysed patients operated for small-bowel neuroendocrine tumour in our institution between 2007 and 2015, and receiving our preventive local regimen of octreotide continuous administration. ioCS was defined as highly probable in case of rapid (<5 min) arterial blood pressure changes ≥40%, not explained by surgical/anaesthetic management and regressive ≥20% after octreotide bolus injection. Probable cases were ioCS which did not meet all criteria of highly-probable ioCS. Suspected ioCS were detected on the anaesthesia record by an injection of octreotide due to a manifestation which did not meet the criteria for highly-probable or probable ioCS. A total of 81 patients (liver metastases: 59, prior carcinoid syndrome: 49, carcinoid heart disease: 7) were included; 139 ioCS occurred in 45 patients: 45 highly probable, 67 probable and 27 suspected. ioCs was hypertensive (91%) and/or hypotensive (29%). There was no factor, including the use of vasopressors, significantly associated with the occurrence of an ioCS. All surgeries were completed and one patient died from cardiac failure 4 days after surgery. After preoperative octreotide continuous infusion, ioCS were mainly hypertensive. No ioCS risk factors, including vasopressor use, were identified. No intraoperative carcinoid crisis occurred, suggesting the clinical relevance of a standardized octreotide prophylaxis protocol.

Open access

Katherine Van Loon, Li Zhang, Jennifer Keiser, Cendy Carrasco, Katherine Glass, Maria-Teresa Ramirez, Sarah Bobiak, Eric K Nakakura, Alan P Venook, Manisha H Shah and Emily K Bergsland

tumor, the presence or absence of liver metastases, and the presence or absence of bone metastases were abstracted from the medical records. For patients who were identified as having any bone metastases, date of detection, date of first reported

Open access

Shan Wu, Jianjun Zhou, Jing Guo, Zhan Hua, Jianchen Li and Zai Wang

were calculated by SPSS ver.13.0 (SPSS Inc.) and were used for data analysis. The number of liver metastases was assessed by counting surface tumor nodules on the liver with a dissecting microscope ( 25 ). Student’s t test was used for calculating the

Open access

Kosmas Daskalakis, Marina Tsoli, Anna Angelousi, Evanthia Kassi, Krystallenia I Alexandraki, Denise Kolomodi, Gregory Kaltsas and Anna Koumarianou

.680 Inheritance Sporadic Familial (MEN1) 67 6 17 2 0.751 Primary tumour site Pancreas Small intestinal Lung/thymus Unknown primary (UPO) 42 19 7 5 15 2 0 2 0.188 Liver Tumour load No liver metastases <5 unilobar liver metastases 5

Open access

Ashley K Clift, Omar Faiz, Robert Goldin, John Martin, Harpreet Wasan, Marc-Olaf Liedke, Erik Schloericke, Anna Malczewska, Guido Rindi, Mark Kidd, Irvin M Modlin and Andrea Frilling

grade  G1 62 (88.6)  G2 6 (8.6)  G3 2 (2.8) Tumour stage  T 1–4 N 0 M 0 7 (10)  T 1–4 N 1 M 0 19 (27.1)  T 1–4 N 0 M 1 1 (1.4)  T 1–4 N 1 M 1 43 (61.4) Liver metastases  Yes

Open access

Wentao Zhou, Tiantao Kuang, Xu Han, Wenqi Chen, Xuefeng Xu, Wenhui Lou and Dansong Wang

.4%) were G3. Among the entire cohort, nine patients (5.2%) with liver metastases underwent synchronously curative resections. Detailed characteristics are summarized in Table 1 . Table 1 Baseline characteristics of pancreatic neuroendocrine neoplasm

Open access

K G Samsom, L M van Veenendaal, G D Valk, M R Vriens, M E T Tesselaar and J G van den Berg

.1. – – Edfeldt et al 2011 19 SI-NETs ( n  = 18), lymph node metastases ( n  = 17), liver metastases ( n  = 7) Gene expression arrays, qPCR Three clusters of gene expression profiles were identified distinguishing primary tumours (11/18) from lymph

Open access

Logan Mills, Panagiotis Drymousis, Yogesh Vashist, Christoph Burdelski, Andreas Prachalias, Parthi Srinivasan, Krishna Menon, Corina Cotoi, Saboor Khan, Judith Cave, Thomas Armstrong, Martin O Weickert, Jakob Izbicki, Joerg Schrader, Andreja Frilling, John K Ramage and Raj Srirajaskanthan

-operatively diagnosed liver metastases or a new diagnosis of distant metastasis. Statistical analysis Data were described as mean values with standard deviation ( s.d. ). Comparison between groups was performed using χ 2 or the Fisher exact test for categorical

Open access

Chao-bin He, Yu Zhang, Zhi-yuan Cai and Xiao-jun Lin

. 201816). References 1 Frilling A Modlin IM Kidd M Russell C Breitenstein S Salem R Kwekkeboom D Lau WY Klersy C Vilgrain V , et al . Recommendations for management of patients with neuroendocrine liver metastases . Lancet Oncology 2014 15