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Kristin Godang, Karolina Lundstam, Charlotte Mollerup, Stine Lyngvi Fougner, Ylva Pernow, Jörgen Nordenström, Thord Rosén, Svante Jansson, Mikael Hellström, Jens Bollerslev, Ansgar Heck and the SIPH Study Group

asymptomatic PHPT. The patients were randomized to either parathyroidectomy (PTX) or observation without intervention (OBS). We found no significant treatment effect of PTX on cardiovascular risk factors including serum lipids after 2 years of follow-up in the

Open access

Isabel M Abreu, Eva Lau, Bernardo de Sousa Pinto and Davide Carvalho

hypothyroidism should be treated, including those with a serum TSH value below 10 IU/L ( 14 ). To our knowledge, the data regarding the effect of levothyroxine treatment on lipid levels in selected patients, including apolipoproteins, originated from small

Open access

Stavroula A Paschou, Eleni Palioura, Dimitrios Ioannidis, Panagiotis Anagnostis, Argyro Panagiotakou, Vasiliki Loi, Georgios Karageorgos, Dimitrios G Goulis and Andromachi Vryonidou

Introduction Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation and hyperandrogenism ( 1 ). It is often accompanied by insulin resistance ( 2 ) and abnormal lipid profile ( 3 , 4 ). Several studies have shown that

Open access

Peter Wolf, Yvonne Winhofer, Martin Krššák and Michael Krebs

adapt adequately to situations of increased cardiac stress. In this review, we aim to overview the influence of hormones on heart function, focusing on their impact on myocardial lipid metabolism, cardiac substrate utilization and ectopic lipid

Open access

Lang Qin, Xiaoming Zhu, Xiaoxia Liu, Meifang Zeng, Ran Tao, Yan Zhuang, Yiting Zhou, Zhaoyun Zhang, Yehong Yang, Yiming Li, Yongfei Wang and Hongying Ye

associated with hypercortisolism. Intensive cholesterol reduction may be beneficial in the treatment of patients with hypertension and normal lipid levels, through a reduction in large artery stiffness. Ferrier found an additional statin therapy led to a

Open access

Giorgio Bedogni, Andrea Mari, Alessandra De Col, Sofia Tamini, Amalia Gastaldelli and Alessandro Sartorio

Few data are available on the association between serum lipids and insulin secretion (ISEC) in children. We evaluated the association of triglycerides (TG), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) with ISEC in 1150 non-diabetic obese children and adolescents using multivariable robust median regression. The following models were employed: 1) IGI or incAUCR as the ISEC response variable; 2) QUICKI, OGIS, the Stumvoll index or the Matsuda insulin sensitivity index as the insulin sensitivity (ISEN) predictor; 3) TG, HDL-C and LDL-C as the predictors of interest; 4) 120 min-glucose, age, sex and body mass index as confounders. LDL-C and TG were not associated with ISEC in any model. In 3 out of 4 IGI models, an increase of 1 interquartile range (IQR) of HDL-C was associated with a decrease of median incAUCR ranging from -9 (robust 95%CI -17 to -2) to -8 (-14 to -1) pmol/mmol. In 2 out of 4 incAUCR models, an increase of 1 IQR of HDL-C was associated with a decrease of median IGI ranging from -8 (-15 to -1) to -7 (-11 to -2) pmol/mmol. TG and LDL-C are not associated and HDL-C is inversely associated with ISEC in obese children and adolescents.

Open access

Marcus Quinkler, Bertil Ekman, Claudio Marelli, Sharif Uddin, Pierre Zelissen, Robert D Murray and on behalf of the EU-AIR Investigators

glucocorticoid replacement. We showed clearly that prednisolone leads to an adverse lipid profile with increased total and LDL cholesterol levels. The significantly higher LDL levels in patients with AI treated with prednisolone vs those treated with

Open access

Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller and Henning Grønbæk

as obesity, sepsis, insulin resistance, diabetes mellitus type 2 (DM2) and non-alcoholic fatty liver disease (NAFLD) ( 1 , 2 , 3 , 4 , 5 , 6 ). These diseases are also associated with changes in the lipid metabolism, accelerated lipolysis and

Open access

Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey and Christopher J Kenyon

processes involve non-genomic enzyme activation, transcriptional control is also important. Long-term supply of cholesterol substrate is maintained by de novo synthesis, by uptake from the circulation and by release from stored intracellular lipid

Open access

Julia Kubiak, Per Medbøe Thorsby, Elena Kamycheva and Rolf Jorde

beneficial effects on total-cholesterol, HDL-cholesterol and triglycerides were found, whereas an increase in LDL-cholesterol was seen ( 13 ). In Challoumas’ review of 19 relevant RCTs, only one reported benefits of vitamin D supplementation on lipid profile