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adversely affect the quality of life ( 5 , 6 , 7 ). Between 65 and 85% of GO patients exhibit lacrimal gland involvement, which manifests as dryness, photophobia, tearing, and even corneal damage ( 8 , 9 ). Some studies have shown that lacrimal glands in
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hypothyroidism have more multiple organ presentations, such as skin, joints, eyes, liver, and lacrimal glands showing sarcoid presentations than typical pulmonary sarcoidosis ( 26 ). Both sarcoidosis and thyroid disease have been associated with HLA genes
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
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Developmental Endocrinology Research Group, Royal Hospital for Children, University of Glasgow, Glasgow, UK
Office for Rare Conditions, University of Glasgow, Glasgow, UK
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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, body weight, and pubertal stage. Adverse effects associated with 131 I therapy depend on the cumulative activity administered and include salivary gland dysfunction and lacrimal gland dysfunction, and concerns exist upon an increased risk for secondary
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patient's symptoms of proptosis were reduced. Another case report describes a patient with adult growth hormone deficiency who presented with bilateral lacrimal gland and eyelid swelling 1 month after initiation of GH therapy and was diagnosed with GO
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pathogenic TRAb stimulated iodine uptake in the thyroid follicular epithelium in GD patients. NIS is a key protein involved in iodine uptake in the thyroid follicular epithelium, mainly distributed in the thyroid, mammary and salivary glands, lacrimal gland