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Thiago U Pantaleão, Andrea C F Ferreira, Maria C S Santos, Álvaro S P Figueiredo, Ruy A N Louzada, Doris Rosenthal, Denise P Carvalho and Vânia M Corrêa da Costa

important deleterious effects on central nervous system. In the brain, most nuclear triiodothyronine (T 3 ) is locally produced from the prohormone thyroxine (T 4 ) by type 2 iodothyronine deiodinase (D2) ( 5 ). Since deiodinases regulate the metabolism of

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David P Sonne, Asger Lund, Jens Faber, Jens J Holst, Tina Vilsbøll and Filip K Knop

mediated through TGR5-induced intracellular cAMP formation and activation of the intracellular type 2 iodothyronine deiodinase (D2), which converts thyroxine (T 4 ) into the active thyroid hormone triiodothyronine (T 3 ). Up to date, human studies have

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Christin Krause, Martina Grohs, Alexander T El Gammal, Stefan Wolter, Hendrik Lehnert, Oliver Mann, Jens Mittag and Henriette Kirchner

.1210/jc.2002-022013 27 Richard K Hume R Kaptein E Sanders JP Van Toor H De Herder WW Den Hollander JC Krenning EP Visser TJ. Ontogeny of iodothyronine deiodinases in human liver . Journal of Clinical Endocrinology and Metabolism 1998 83 2868

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Caroline Serrano-Nascimento, Rafael Barrera Salgueiro, Kaio Fernando Vitzel, Thiago Pantaleão, Vânia Maria Corrêa da Costa and Maria Tereza Nunes

Technologies). The expression of thyrotropin-releasing hormone (Trh), Trh receptor (Trhr), type 2 iodothyronine deiodinase (Dio2), alpha subunit of thyrotropin (Tsha), beta subunit of thyrotropin (Tshb), thyrotropin receptor (Tshr), sodium

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Aaron Lerner, Patricia Jeremias and Torsten Matthias

Rand W Emerson C Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome . Endocrinology 2004 145 1649 – 1655 . ( doi:10.1210/en.2003-1439 ) 22

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Arno Téblick, Lies Langouche and Greet Van den Berghe

-09-0290 ) 19439506 10.1530/EJE-09-0290 35 Mebis L Langouche L Visser TJ Van den Berghe G . The type II iodothyronine deiodinase is up-regulated in skeletal muscle during prolonged critical illness . Journal of Clinical Endocrinology and

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Stefano Mangiola, Ryan Stuchbery, Patrick McCoy, Ken Chow, Natalie Kurganovs, Michael Kerger, Anthony Papenfuss, Christopher M Hovens and Niall M Corcoran

iodothyronine deiodinase 2 ( DIO2 ), which is associated with the biosynthesis of thyroid hormone ( 42 ) and cyclin A1 ( CCNA1 ), which is involved in spermatogenesis ( 43 ). For inflammation, upregulated genes were enriched over downregulated genes ( n  = 7 vs

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Flavia Letícia Martins Peçanha, Reinaldo Sousa dos Santos and Wagner Seixas da-Silva

28 116 – 123 . ( doi:10.1002/nbm.3233 ) 34 Zavacki AM Ying H Christoffolete MA Aerts G So E Harney JW Cheng S Larsen PR Bianco AC. Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid

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Madalena von Hafe, João Sergio Neves, Catarina Vale, Marta Borges-Canha and Adelino Leite-Moreira

Metabolism 1983 57 181 – 189 . ( ) 10.1210/jcem-57-1-181 74 Huang SA Tu HM Harney JW Venihaki M Butte AJ Kozakewich HP Fishman SJ Larsen PR . Severe hypothyroidism caused by type 3 iodothyronine deiodinase in

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Bilal B Mughal, Jean-Baptiste Fini and Barbara A Demeneix

– 28 . ( ) 10.1016/j.tox.2010.08.012 20804816 365 Roberts SC Bianco AC Stapleton HM. Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers