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Qi Che, Xirong Xiao, Jun Xu, Miao Liu, Yongning Lu, Suying Liu, and Xi Dong

-onset menopause and use of tamoxifen, while type II is more aggressive and estrogen independent ( 2 , 3 ). Disturbance of cell invasion and aggressive behavior is one of the main malignant characters of cancer cells ( 4 ). Therefore, understanding the underlying

Open access

Linfei Yang, Xiao Yu, and Yongchao Yang

. Knockdown effectiveness was assessed by Western blot for total ATX and STAT3 levels. Cell migration and invasion assay A 24-well plate containing a 12-µm pore size polycarbonate membrane insert (Corning) coated with a uniform layer of dried basement

Open access

Juan Carlos Juárez-Cruz, Miriam Daniela Zuñiga-Eulogio, Monserrat Olea-Flores, Eduardo Castañeda-Saucedo, Miguel Ángel Mendoza-Catalán, Carlos Ortuño-Pineda, Ma Elena Moreno-Godínez, Sócrates Villegas-Comonfort, Teresita Padilla-Benavides, and Napoleón Navarro-Tito

Introduction Breast cancer is the most common invasive neoplasia and the second-leading cause of cancer-related death in women worldwide. Over 2,000,000 cases are diagnosed annually worldwide, which represents the highest incidence of cancer

Open access

Cleofas Marcial-Medina, Alejandra Ordoñez-Moreno, Christian Gonzalez-Reyes, Pedro Cortes-Reynosa, and Eduardo Perez Salazar

fatty acids (FFAs) ( 1 , 2 , 3 , 4 ). FFAs are an energy source, and induce activation of signal transduction pathways in breast cancer cells ( 5 , 6 , 7 , 8 ). Particularly, oleic acid (OA) induces proliferation, migration and invasion of breast

Open access

Anello Marcello Poma, Riccardo Giannini, Paolo Piaggi, Clara Ugolini, Gabriele Materazzi, Paolo Miccoli, Paolo Vitti, and Fulvio Basolo

classified as minimally invasive (MI-FTC) and widely invasive (WI-FTC) ( 3 ), cannot be determined by fine-needle aspiration cytology (FNAC), since the demonstration of malignancy in these types of lesions is based on the presence of capsular and/or vascular

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Hanbaro Kim, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Shadi Alshammary, and Song Cheol Kim

portal vein invasion also underwent portal vein resection. Our center has the following polices for surgical resection of PNETs: (1) F-PNETs are surgically resected; (2) for NF-PNETs in the body and tail, tumors less than 1 cm are observed and tumors

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Ana Carolina de Jesus Paniza, Thais Biude Mendes, Matheus Duarte Borges Viana, Débora Mota Dias Thomaz, Paula B O Chiappini, Gabriel A Colozza-Gama, Susan Chow Lindsey, Marcos Brasilino de Carvalho, Venâncio Avancini Ferreira Alves, Otavio Curioni, André Uchimura Bastos, and Janete Maria Cerutti

), when the tumor is surrounded by a fibrous capsule, and infiltrative FVPTC (IFVPTC), when there is no capsule. For EFVPTC without invasion of the capsule or its vessels, the diagnosis of malignancy relies solely on the presence of the nuclear features

Open access

Wei Sun, Boyuan Zheng, Zhihong Wang, Wenwu Dong, Yuan Qin, and Hao Zhang

possible risk factors of CCLNM and the corresponding numbers of patients. The nine risk factors comprised sex, age, tumor size, multifocality, extrathyroidal extension, capsular invasion, lymphovascular invasion, Hashimoto thyroiditis, and ipsilateral

Open access

Simon Schimmack, Yongchao Yang, Klaus Felix, Markus Herbst, Yixiong Li, Miriam Schenk, Frank Bergmann, Thilo Hackert, and Oliver Strobel

qualitative PCR was also performed in order to confirm the presence of single and appropriate bands for each primer set. PCR data were analyzed using the ΔΔCT method as previously described ( 40 ). Cell migration and invasion assays The migration and

Open access

Guoquan Zhu, Yuying Deng, Liqin Pan, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang, Yanying Chen, and Jiaxin Luo

metastasis. In recent years, an increasing number of molecular genetic characteristics associated with invasiveness and clinical management have been uncovered, including the BRAF V600E mutation, TERT promoter mutations, RAS mutations and RET