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Anne Jouinot Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France
Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Juliane Lippert Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Wuerzburg, Wuerzburg, Germany

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Martin Fassnacht Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Wuerzburg, Wuerzburg, Germany
Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Wuerzburg, Germany

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Bruno de La Villeon Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France

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Amandine Septier Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France

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Mario Neou Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France

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Karine Perlemoine Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France

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Silke Appenzeller Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Wuerzburg, Wuerzburg, Germany

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Mathilde Sibony Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France
Department of Pathology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Sébastien Gaujoux Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France
Department of Digestive and Endocrine Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Bertrand Dousset Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France
Department of Digestive and Endocrine Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Rossella Libe Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France
Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Lionel Groussin Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France
Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Cristina L Ronchi Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Wuerzburg, Wuerzburg, Germany
Institute of Metabolism and System Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Guillaume Assié Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France
Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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Jérôme Bertherat Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France
Department of Endocrinology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France

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mutations, chromosome alteration and DNA methylation profile, or at the RNA level, including transcriptome and targeted gene expression profiles. Intratumor heterogeneity of somatic mutations has been reported in many cancer types ( 12 , 13 , 14 ). In a

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Jordyn Silverstein Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Wesley Kidder Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Susan Fisher Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA

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Thomas A Hope Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA

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Samantha Maisel Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Dianna Ng Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Pathology, University of California, San Francisco, California, USA

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Jessica Van Ziffle Department of Pathology, University of California, San Francisco, California, USA

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Chloe E Atreya Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Katherine Van Loon Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA

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N Stewart A , et al . Intratumor heterogeneity and branched evolution revealed by multiregion sequencing . New England Journal of Medicine 2012 366 883 – 892 . ( https://doi.org/10.1056/NEJMoa1113205 )

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Yang Lv Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Xu Han Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Chunyan Zhang Department of Clinical Laboratory, Zhongshan Hospital, Fudan University, Shanghai, China

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Yuan Fang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Ning Pu Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yuan Ji Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Dansong Wang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Xu Xuefeng Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Wenhui Lou Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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.1159/000443167 26731013 2 Gerlinger M Rowan AJ Horswell S Larkin J Endesfelder D Gronroos E Martinez P Matthews N Stewart A Tarpey P Intratumor heterogeneity and branched evolution revealed by multiregion sequencing . New England Journal of Medicine 2012 366

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