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hypothyroidism have a high risk for insulin resistance-associated disorders, such as metabolic syndrome and cardiovascular disease ( 1 , 2 ). Moreover, independent of other variables, a significant positive association exists between TSH levels and insulin
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark
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volume divided by fasting volume. Insulin resistance was calculated using the Homeostasis Model Assessment calculator ( https://www.rdm.ox.ac.uk/about/our-clinical-facilities-and-mrc-units/DTU/software/homa ). Gaussian and non-Gaussian-distributed data
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levels and the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index ( 19 , 20 , 21 ). Moreover, higher concentrations of placental iodine are linked with a lower incidence of GDM, and a lower placental iodine load is associated with an
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); this change may contribute to account for the high prevalence of MetS in the elderly. Previous studies have shown that higher FT3/FT4 and FT3 and lower FT4 were positively associated with increased risk of insulin resistance (IR) ( 30 , 36 , 37 ), and
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, regulates bone metabolism and calcium and phosphorus homeostasis. 25(OH)D deficiency is related to several diseases, including cardiovascular diseases such as hypertension and heart failure ( 5 ), insulin resistance ( 6 ), and autoimmune diseases such as
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DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany
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thyroid dysfunction with NAFLD and hepatic iron overload may be somewhat similar since thyroid hormone alterations, NAFLD, and hepatic iron accumulation are strongly related with metabolic factors, such as obesity and insulin resistance ( 24 , 25 ). The
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in the pro-inflammatory background (interleukin 6 and tumor necrosis factor alpha), insulin resistance, hyperglycemia, dyslipidemia, and altered signaling of thyroid-stimulating hormone, insulin growth factor 1, leptin, adiponectin, and androgens
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transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans . Journal of Clinical Investigation 2012 122 2176 – 2194 . ( https://doi.org/10.1172/JCI41636 ) 76 Domouzoglou EM Fisher FM Astapova I Fox EC