Butte AJ Crunkhorn S Cusi K Berria R Kashyap S Miyazaki Y Kohane I Costello M Saccone R . Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1
Mitochondrial dysfunction and insulin resistance: an update
Magdalene K Montgomery and Nigel Turner
Link between insulin resistance and skeletal muscle extracellular matrix remodeling
Róża Aleksandrowicz and Marek Strączkowski
muscle to insulin, defined as insulin resistance (IR), contribute to the development of obesity, type 2 diabetes mellitus (T2DM), and cardiovascular diseases. Skeletal muscle insulin action is decreased in prediabetes and T2DM, but it also may be largely
Does sex hormone-binding globulin cause insulin resistance during pubertal growth?
Shenglong Le, Leiting Xu, Moritz Schumann, Na Wu, Timo Törmäkangas, Markku Alén, Sulin Cheng, and Petri Wiklund
substantially during puberty ( 6 , 7 ). Along these lines, low serum SHBG level has been associated with increased adiposity and insulin resistance in children and adolescents ( 3 , 8 , 9 , 10 , 11 , 12 ); therefore, it has been hypothesized that SHBG
Longitudinal associations between sex hormone-binding globulin and insulin resistance
Kristin Ottarsdottir, Margareta Hellgren, David Bock, Anna G Nilsson, and Bledar Daka
different cohorts including men and women, respectively, suggesting a causal effect. The mechanism behind the association between SHGB and type 2 diabetes is not fully understood, but may be mediated through insulin resistance ( 5 ). In a meta
Sexual dimorphism in insulin resistance in a metabolic syndrome rat model
Myrian Velasco, Rosa Isela Ortiz-Huidobro, Carlos Larqué, Yuriko Itzel Sánchez-Zamora, José Romo-Yáñez, and Marcia Hiriart
central obesity (based on the waist circumference), dyslipidemia (decreased levels of high-density lipoprotein cholesterol, or hypertriglyceridemia), hypertension, impaired fasting glucose, and insulin resistance ( 5 ). MS diagnosis involves the presence
The association between serum testosterone and insulin resistance: a longitudinal study
Kristin Ottarsdottir, Anna G Nilsson, Margareta Hellgren, Ulf Lindblad, and Bledar Daka
( 10 ). On the other hand, low testosterone levels increase the accumulation of visceral body fat, which increases insulin resistance. This is illustrated by the fact that body fat increases in men with prostate cancer undergoing treatment resulting in
Insulin resistance associates with hepatic lobular inflammation in subjects with obesity
Frederique Van de Velde, Marlies Bekaert, Anja Geerts, Anne Hoorens, Arsène-Hélène Batens, Samyah Shadid, Margriet Ouwens, Yves Van Nieuwenhove, and Bruno Lapauw
methods are NAFLD Activity Score (NAS) and Steatosis, Activity, and Fibrosis (SAF) score ( 3 ). Importantly, patients with obesity who develop NAFLD are also more prone to develop other metabolic consequences of obesity such as insulin resistance (IR
Adrenal hyperandrogenism does not deteriorate insulin resistance and lipid profile in women with PCOS
Stavroula A Paschou, Eleni Palioura, Dimitrios Ioannidis, Panagiotis Anagnostis, Argyro Panagiotakou, Vasiliki Loi, Georgios Karageorgos, Dimitrios G Goulis, and Andromachi Vryonidou
Introduction Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation and hyperandrogenism ( 1 ). It is often accompanied by insulin resistance ( 2 ) and abnormal lipid profile ( 3 , 4 ). Several studies have shown that
Limitations of insulin resistance assessment in polycystic ovary syndrome
Krzysztof C Lewandowski, Justyna Płusajska, Wojciech Horzelski, Ewa Bieniek, and Andrzej Lewiński
out. Though it is widely accepted that PCOS is characterised by insulin resistance ( 4 ), there is no consensus, either regarding the best method of assessment of insulin resistance (IR) in PCOS, nor in terms of the utility of such assessment for
Salivary cortisol is not associated with incident insulin resistance or type 2 diabetes mellitus
Karim Gariani, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, and François R Jornayvaz
(TG) level, increased insulin resistance (IR) and a higher fasting plasma glucose ( 5 ). Patients with T2DM may exhibit evidence of subclinical hypercortisolism such as higher 24-h urine-free cortisol levels, higher plasma cortisol levels after
