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Magdalene K Montgomery and Nigel Turner

Butte AJ Crunkhorn S Cusi K Berria R Kashyap S Miyazaki Y Kohane I Costello M Saccone R . Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1

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Shenglong Le, Leiting Xu, Moritz Schumann, Na Wu, Timo Törmäkangas, Markku Alén, Sulin Cheng, and Petri Wiklund

substantially during puberty ( 6 , 7 ). Along these lines, low serum SHBG level has been associated with increased adiposity and insulin resistance in children and adolescents ( 3 , 8 , 9 , 10 , 11 , 12 ); therefore, it has been hypothesized that SHBG

Open access

Myrian Velasco, Rosa Isela Ortiz-Huidobro, Carlos Larqué, Yuriko Itzel Sánchez-Zamora, José Romo-Yáñez, and Marcia Hiriart

central obesity (based on the waist circumference), dyslipidemia (decreased levels of high-density lipoprotein cholesterol, or hypertriglyceridemia), hypertension, impaired fasting glucose, and insulin resistance ( 5 ). MS diagnosis involves the presence

Open access

Kristin Ottarsdottir, Margareta Hellgren, David Bock, Anna G Nilsson, and Bledar Daka

different cohorts including men and women, respectively, suggesting a causal effect. The mechanism behind the association between SHGB and type 2 diabetes is not fully understood, but may be mediated through insulin resistance ( 5 ). In a meta

Open access

Kristin Ottarsdottir, Anna G Nilsson, Margareta Hellgren, Ulf Lindblad, and Bledar Daka

( 10 ). On the other hand, low testosterone levels increase the accumulation of visceral body fat, which increases insulin resistance. This is illustrated by the fact that body fat increases in men with prostate cancer undergoing treatment resulting in

Open access

Frederique Van de Velde, Marlies Bekaert, Anja Geerts, Anne Hoorens, Arsène-Hélène Batens, Samyah Shadid, Margriet Ouwens, Yves Van Nieuwenhove, and Bruno Lapauw

methods are NAFLD Activity Score (NAS) and Steatosis, Activity, and Fibrosis (SAF) score ( 3 ). Importantly, patients with obesity who develop NAFLD are also more prone to develop other metabolic consequences of obesity such as insulin resistance (IR

Open access

Stavroula A Paschou, Eleni Palioura, Dimitrios Ioannidis, Panagiotis Anagnostis, Argyro Panagiotakou, Vasiliki Loi, Georgios Karageorgos, Dimitrios G Goulis, and Andromachi Vryonidou

Introduction Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation and hyperandrogenism ( 1 ). It is often accompanied by insulin resistance ( 2 ) and abnormal lipid profile ( 3 , 4 ). Several studies have shown that

Open access

Krzysztof C Lewandowski, Justyna Płusajska, Wojciech Horzelski, Ewa Bieniek, and Andrzej Lewiński

out. Though it is widely accepted that PCOS is characterised by insulin resistance ( 4 ), there is no consensus, either regarding the best method of assessment of insulin resistance (IR) in PCOS, nor in terms of the utility of such assessment for

Open access

Karim Gariani, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, and François R Jornayvaz

(TG) level, increased insulin resistance (IR) and a higher fasting plasma glucose ( 5 ). Patients with T2DM may exhibit evidence of subclinical hypercortisolism such as higher 24-h urine-free cortisol levels, higher plasma cortisol levels after

Open access

Rongpeng Gong, Gang Luo, Mingxiang Wang, Lingbo Ma, Shengnan Sun, and Xiaoxing Wei

Background Insulin resistance (IR) is the insensitivity to insulin in insulin-dependent organs and tissues ( 1 ). The clinical manifestation of IR is the failure to respond to increase in blood sugar, which is associated with metabolic