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Xiaolei Hu Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Fengling Chen Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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). It was first reported by Berson and coworkers ( 2 ) that clinical hypersensitivity and insulin resistance were associated with circulating insulin antibodies (IAs) in patients receiving exogenous animal insulin therapy. Over the past few decades, with

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0309
Volume/Issue:
Volume 7: Issue 1
Open access
Ivar Følling Department of Endocrinology, Akershus University Hospital, Lørenskog, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway

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Anna B Wennerstrøm Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway

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Tor J Eide Division of Laboratory Medicine, Department of Pathology, Oslo University Hospital, Oslo, Norway

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Hilde Loge Nilsen Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway

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insulin production are rare. It is found in a few cases with tumours in the cervix, lung, kidney, paraganglioma, and ovary. The evidence for insulin production in these tumours is, for some of them, limited to staining with anti-insulin antibodies ( 4 , 5

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0269
Volume/Issue:
Volume 10: Issue 8
Open access
Gaëtan Prévost Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Marie Picot Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Marie-Anne Le Solliec Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Arnaud Arabo Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Hind Berrahmoune Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Mouna El Mehdi Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Saloua Cherifi Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Alexandre Benani Center for Taste and Feeding Behaviour, CNRS (UMR6265), INRA (UMR1324), Université de Bourgogne-Franche Comté, Dijon , France

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Emmanuelle Nédélec Center for Taste and Feeding Behaviour, CNRS (UMR6265), INRA (UMR1324), Université de Bourgogne-Franche Comté, Dijon , France

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Françoise Gobet Department of Anatomopathophysiology, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France

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Valéry Brunel Department of Biochemistry, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France

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Jérôme Leprince Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Hervé Lefebvre Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Youssef Anouar Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Nicolas Chartrel Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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. In addition, treatment of consecutive sections with the 26RFa antibodies and insulin antibodies revealed that the histological distribution of 26RFa-LI was similar to that of insulin ( Fig. 6A and B ). Supporting this observation, a double

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0247
Volume/Issue:
Volume 8: Issue 7
Open access
Louise Færch Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark

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Anders Juul Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark
Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark

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Ulrik Pedersen-Bjergaard Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark

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Birger Thorsteinsson Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark
Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark

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. Abnormal glucose counterregulation in insulin-dependent diabetes mellitus. Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion . Diabetes 1983 32 134 – 141 . ( doi:10.2337/diabetes.32.2.134 ). 15 Friedrich N Krebs

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0012
Volume/Issue:
Volume 1: Issue 1
Open access
Wei Liu Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Yunke Ma Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Xiaoling Cai Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Yu Zhu Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Mingxia Zhang Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Juan Li Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Jing Chen School of Automation, Beijing Institute of Technology, Beijing, People’s Republic of China

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Dawei Shi School of Automation, Beijing Institute of Technology, Beijing, People’s Republic of China

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Linong Ji Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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insulin therapy; at least one positive diabetes autoantibody (anti-glutamic acid decarboxylase autoantibody, islet cell antibodies and insulin antibody). Meanwhile, in order to confirm the diagnosis of type 1 diabetes, for the participants with less than 1

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0244
Volume/Issue:
Volume 11: Issue 11
Open access
Peter L Kristensen Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark

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Ulrik Pedersen-Bjergaard Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Rikke Due-Andersen Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Lægerne på Ellemarksvej, Køge, Denmark

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Thomas Høi-Hansen Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Department of Cardiology, Herlev-Gentofte University Hospital, Herlev, Denmark

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Lise Grimmeshave Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Novo Nordisk A/S, Søborg, Denmark

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Valeriya Lyssenko Steno Diabetes Center, Gentofte, Denmark
Lund University Diabetes Centre, Skåne University Hospital, Malmø, Sweden

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Leif Groop Lund University Diabetes Centre, Skåne University Hospital, Malmø, Sweden
Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland

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Jens J Holst Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, The Panum Institute, Copenhagen, Denmark

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Allan A Vaag Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Endocrinology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

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Birger Thorsteinsson Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Gerich JE. Abnormal glucose counterregulation in insulin-dependent diabetes mellitus. Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion . Diabetes 1983 32 134 – 141 . ( doi:10.2337/diab.32.2.134 ) 21

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0050
Volume/Issue:
Volume 5: Issue 6
Open access
Caio Jordão Teixeira Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Junia Carolina Santos-Silva Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Dailson Nogueira de Souza Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Alex Rafacho Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil

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Gabriel Forato Anhe Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Silvana Bordin Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

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–9999 µm 2 ), large (10,000–49,999 µm 2 ) or very large (≥50,000 µm 2 ) islets based on a previous investigation ( 18 ). An example of a section stained with anti-insulin antibody and the respective classification of its islets according to their sizes are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0505
Volume/Issue:
Volume 8: Issue 2
Open access
Sara Ullsten Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Sara Bohman Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Marie E Oskarsson Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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K Peter R Nilsson Department of Chemistry, Linköping University, Linköping, Sweden

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Gunilla T Westermark Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Per-Ola Carlsson Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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this article). Prohormone convertase (PC) protein levels in mouse islets Pancreas sections obtained from animals fed 3-month HFD were incubated with monoclonal mouse PC1/3 and PC2 antibodies ( 22 ) together with an insulin antibody (Fitzgerald

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0148
Volume/Issue:
Volume 6: Issue 7
Open access
Ping Gu Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Yuege Lin Department of Pathology, Nanjing Medical University, Nanjing, China

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Qi Wan Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Dongming Su Department of Pathology, Nanjing Medical University, Nanjing, China

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Qun Shu Department of Obstetrics, Shanghai First Maternity and Infant Health Hospital, School of Medicine, Tongji University, Shanghai, China

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expression of oxytocin receptor (OXTR) in the islet endocrine cells was detected in the tissue sections from vehicle-treated gestation (G) and non-gestating (NG) female mice. Immunohistochemical staining using insulin antibody and double

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0043
Volume/Issue:
Volume 10: Issue 7
Open access
Jonathan Hazlehurst Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Bernard Khoo Endocrinology, Division of Medicine, University College London, London, UK

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Carolina Brito Lobato Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Medicine, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark

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Ibiyemi Ilesanmi Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK

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Sally Abbott Department of Dietetics, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

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Tin Chan Faculty of Medicine, Chinese University of Hong Kong, Hong Kong

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Sanesh Pillai Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Kate Maslin School of Nursing and Midwifery, University of Plymouth, Plymouth, UK

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Sanjay Purkayastha Brunel University, London, UK
Imperial College Healthcare NHS Trust, St Mary’s Hospital, London, UK

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Barbara McGowan Endocrinology, Guys’ and St Thomas’s NHS Foundation Trust, London, UK

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Rob Andrews University of Exeter Medical School, Exeter, UK

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Eveleigh Nicholson Portsmouth Hospitals University NHS Trust, Portsmouth, UK

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Katherine McCullough Royal Surrey County Hospital, Guildford, UK

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Lorraine Albon University Hospitals Sussex NHS Foundation Trust, Worthing, UK

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Rachel Batterham Endocrinology, Division of Medicine, University College London, London, UK

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Georgios K Dimitriadis King's College Hospital NHS Foundation Trust, London, UK

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Shareen Forbes BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Gavin Bewick School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK

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Tricia M-M Tan Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK

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drugs such as insulin and sulphonylureas, other drugs such as quinine and hydroxychloroquine, causes of endogenous hyperinsulinaemia such as insulin- or proinsulin-secreting tumours, anti-insulin antibody syndrome and non-hyperinsulinaemic causes of

Article Type:
Other
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0285
Volume/Issue:
Volume 13: Issue 5
Open access