Search Results

You are looking at 1 - 10 of 342 items for :

Clear All
Open access

B Fabre, G Maccallini, A Oneto, D Gonzalez, V Hirschler, C Aranda and G Berg

(associated with carbohydrate intolerance), type 2 diabetes mellitus, and metabolic syndrome in the population, particularly in children, all primarily due to changes in their lifestyle (5, 6, 7) . Insulin that is actively transported to the saliva from its

Open access

Bledar Daka, Thord Rosen, Per Anders Jansson, Lennart Råstam, Charlotte A Larsson and Ulf Lindblad

, 10) . Moreover, in vitro studies have shown that insulin might inhibit production of SHBG in human hepatoma cells (11) , and in accordance with these findings an inhibitory effect of insulin on SHBG secretion has been reported (12) . In contrast

Open access

Yusaku Mori, Eunhyoung Ko, Rudolf Furrer, Linda C Qu, Stuart C Wiber, I George Fantus, Mario Thevis, Alan Medline and Adria Giacca

Introduction Insulin treatment is life saving for type 1 diabetes and essential for achieving glycaemic control and thus preventing complications in type 2 diabetes. However, insulin has mitotic properties in addition to its well

Open access

P R van Dijk, S J J Logtenberg, K H Groenier, N Kleefstra, H J G Bilo and H J Arnqvist

Introduction Insulin and insulin-like growth factor 1 (IGF1) are structurally and functionally closely related peptides. IGF1, mainly synthesized in the liver after stimulation of the GH receptor, plays a central role in cell metabolism and growth

Open access

L Ahlkvist, K Brown and B Ahrén

Introduction In fully compensated insulin resistance, there is a sufficient upregulation of insulin secretion whereas in glucose intolerance and type 2 diabetes this upregulation is inadequate (1) . Several mechanisms have been suggested to

Open access

Doron Weinstein, Rive Sarfstein, Zvi Laron and Haim Werner

are effectively used in clinical settings (2, 4) . The insulin-like growth factor (IGF) system has an important role in the normal growth and development of the prostate gland (5) . In addition to its physiological role, epidemiological, clinical

Open access

Jothydev Kesavadev, Pradeep Babu Sadasivan Pillai, Arun Shankar, Gopika Krishnan and Sunitha Jothydev

require insulin therapy due to inadequate glycemic control with oral agents ( 1 ). Metformin and sulfonylureas (SU) are the most commonly used oral antidiabetic agents. However, SU have a greater tendency to cause hypoglycemia and weight gain and hence

Open access

Borros Arneth

Introduction Type 1 diabetes mellitus (DM) is an autoimmune disease in which T-lymphocytes attack insulin-producing beta cells in the pancreas ( 1 ). During the later stages of this progressive disease, pancreatic beta cells are massively

Open access

Leanne Hodson and Fredrik Karpe

impaired insulin-dependent regulation of glucose and hepatic lipid metabolism ( 3 ). Hyperinsulinaemia is a common finding in obesity, and may be the result of insulin hypersecretion and/or impaired hepatic insulin extraction; individuals with

Open access

Kaisa K Ivaska, Maikki K Heliövaara, Pertti Ebeling, Marco Bucci, Ville Huovinen, H Kalervo Väänänen, Pirjo Nuutila and Heikki A Koistinen

originally identified in mice, in which OC was shown to act as a hormone to increase proliferation of pancreatic β cells, insulin secretion and insulin sensitivity (3, 4) . Osteocalcin is specifically expressed in osteoblasts and osteocytes, and it is