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Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, Riitta Parkkola, Vesa Oikonen, Andrea Mari, Andreas Lindqvist, Nils Wierup, Leif Groop and Pirjo Nuutila

several potential vasoactive substances increase ( 8 ). In rodents, experimental hyperglycemia increases and hypoglycemia decreases pancreatic islet perfusion ( 9 ). Moreover, incretins have been shown to regulate BF in the splanchnic and systemic

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Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou and Zubing Mei

. Incretin-based drugs, including glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase 4 (DPP-4) inhibitors, may offer an opportunity to avoid these side effects. Theoretically, GLP-1 RAs are structurally and functionally similar to

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Kim K B Clemmensen, Jonas S Quist, Dorte Vistisen, Daniel R Witte, Anna Jonsson, Oluf Pedersen, Torben Hansen, Jens J Holst, Torsten Lauritzen, Marit E Jørgensen, Signe Torekov and Kristine Færch

). Additionally, the time of the day of an OGTT seems to influence the glucose response with higher post-load blood glucose levels in the afternoon and evening compared to the morning ( 1 , 3 ). The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose

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David P Sonne, Asger Lund, Jens Faber, Jens J Holst, Tina Vilsbøll and Filip K Knop

during both oral and i.v. glucose and thereby contribute to the observed TSH suppression patterns (11) . Also, as GIP and GLP1 increase somatostatin secretion, at least in animals (34) , suppression of TSH during incretin infusion might have been

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Marloes Emous, Merel van den Broek, Ragnhild B Wijma, Loek J M de Heide, Gertjan van Dijk, Anke Laskewitz, Erik Totté, Bruce H R Wolffenbuttel and André P van Beek

these variations, only within-subject changes from baseline were used for analysis. The maximum storage was 30 months. We did not analyse stability of the incretins, but we assume that with the precautions made (immediate storage), stability was

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Aldo Bonaventura, Fabrizio Montecucco and Franco Dallegri

hypoglycemia (31% lower) (76) . The frequency of hypoglycemia with new GLDs, such as incretins and SGLT2 inhibitors, is very low (77) . Results of some trials indicated the efficacy of dipeptidyl peptidase (DPP)-4 inhibitors in improving glycemic control

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Annieke C G van Baar, Andrei Prodan, Camilla D Wahlgren, Steen S Poulsen, Filip K Knop, Albert K Groen, Jacques J Bergman, Max Nieuwdorp and Evgeni Levin

, metabolic syndrome (MetS) and type 2 diabetes ( 1 ). The gut incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), produced by enteroendocrine L cells and K cells, respectively, are intimately involved in

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Henri Honka, Jukka Koffert, Saila Kauhanen, Nobuyuki Kudomi, Saija Hurme, Andrea Mari, Andreas Lindqvist, Nils Wierup, Riitta Parkkola, Leif Groop and Pirjo Nuutila

incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) account for the gut-derived amplification of insulin secretion ( 4 ). In addition to the effect on pancreatic islets, we ( 5 ) and others ( 6 ) have

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Agnieszka Kosowska, Enrique Gallego-Colon, Wojciech Garczorz, Agnieszka Kłych-Ratuszny, Mohammad Reza F Aghdam, Michał Woz´niak, Andrzej Witek, Agnieszka Wróblewska-Czech, Anna Cygal, Jerzy Wojnar and Tomasz Francuz

( 4 ). Alternatively, incretin mimetic drugs are a relatively new group of drugs used in the treatment of diabetes that are currently recommended by American Diabetes Association in dual therapy with metformin for the treatment of T2D ( 5 , 6 ). The

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Amalie R Lanng, Lærke S Gasbjerg, Natasha C Bergmann, Sigrid Bergmann, Mads M Helsted, Matthew P Gillum, Bolette Hartmann, Jens J Holst, Tina Vilsbøll and Filip K Knop

). Likewise, the effect of alcohol on the secretion of the gut-derived insulinotropic incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) remains unclear ( 6 , 11 , 12 ). Recently, alcohol was shown to