Qing Zhu
Qing Zhu
Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China
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Jianbin Su
Jianbin Su
Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China
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Xueqin Wang
Xueqin Wang
Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China
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Mengjie Tang
Mengjie Tang
Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China
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Yingying Gao
Yingying Gao
Department of Rheumatology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China
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Dongmei Zhang
Dongmei Zhang
Clinical Medicine Research Center, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China
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still unclear and may be related to genetics, environment, immunity and other factors, among which immune response is the core factor. It is recognised that the autoimmune process may have a very important pathogenic role in Graves’ disease ( 2 ). A
Fabian Eichelmann
Fabian Eichelmann
Department of Epidemiology, Nutrition, Immunity and Metabolism Start-up Lab, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany
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Cornelia Weikert
Cornelia Weikert
Department of Food Safety, Federal Institute for Risk Assessment
Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany
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Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany
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Romina di Giuseppe
Romina di Giuseppe
Institute of Epidemiology, Christian-Albrechts University Kiel, Kiel, Germany
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Ronald Biemann
Ronald Biemann
Department for Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany
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Berend Isermann
Berend Isermann
Department for Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany
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Matthias B Schulze
Matthias B Schulze
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany
German Center of Diabetes Research (DZD), München-Neuherberg, Germany
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German Center of Diabetes Research (DZD), München-Neuherberg, Germany
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Heiner Boeing
Heiner Boeing
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany
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Krasimira Aleksandrova
Krasimira Aleksandrova
Department of Epidemiology, Nutrition, Immunity and Metabolism Start-up Lab, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany
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Introduction Chemerin, also known as tazarotene-induced gene 2 protein (TIG2) and retinoic acid receptor responder 2 (RARRES2), is a 14-kDa chemoattractant protein known to modulate immune system function through its binding to the chemerin
Maria Stelmachowska-Banaś
Maria Stelmachowska-Banaś
Department of Endocrinology, The Centre of Postgraduate Medical Education, Warsaw, Polska, Poland
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Izabella Czajka-Oraniec
Izabella Czajka-Oraniec
Department of Endocrinology, The Centre of Postgraduate Medical Education, Warsaw, Polska, Poland
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Introduction Over the past several years, immunotherapy with immune checkpoint inhibitors (ICIs) has become an effective treatment of many malignancies. Immune checkpoints are molecules on the surface of immune cells involved in the regulation
Ruth Percik
Ruth Percik
Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Centre, Ramat Gan, Israel
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Sherwin Criseno
Sherwin Criseno
Department of Endocrinology, University Hospital Birmingham, Birmingham, UK
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Safwaan Adam
Safwaan Adam
Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK
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Kate Young
Kate Young
Royal Marsden Hospital, London, UK
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Daniel L Morganstein
Daniel L Morganstein
Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
Royal Marsden Hospital, London, UK
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Royal Marsden Hospital, London, UK
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Introduction Endocrinopathies are amongst the most frequent adverse events of immune checkpoint inhibitors (ICPIs). In common with all other side effects of systemic anticancer treatment, they are currently reported according to the Common
Irasema Mendieta
Irasema Mendieta
Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico
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Rosa Elvira Nuñez-Anita
Rosa Elvira Nuñez-Anita
Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás Hidalgo, Morelia, Michoacán, Mexico
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Gilberto Pérez-Sánchez
Gilberto Pérez-Sánchez
Departmento de Psicoimunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico
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Lenin Pavón
Lenin Pavón
Departmento de Psicoimunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico
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Alfredo Rodríguez-Cruz
Alfredo Rodríguez-Cruz
Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico
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Guadalupe García-Alcocer
Guadalupe García-Alcocer
Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico
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Laura Cristina Berumen
Laura Cristina Berumen
Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico
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various factors, including hormones and neurotransmitters. In the recent years, there has been an increasing interest in the role of these factors as immunomodulators in bidirectional communication with the immune system ( 11 ). In some cancers, it has
Hanna Karhapää
Hanna Karhapää
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Siru Mäkelä
Siru Mäkelä
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Hanna Laurén
Hanna Laurén
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Marjut Jaakkola
Marjut Jaakkola
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Camilla Schalin-Jäntti
Camilla Schalin-Jäntti
Medical Faculty, University of Helsinki, Helsinki, Finland
Endocrinology, Abdominal Centre, University of Helsinki and HUS, Helsinki, Finland
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Endocrinology, Abdominal Centre, University of Helsinki and HUS, Helsinki, Finland
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Micaela Hernberg
Micaela Hernberg
Medical Faculty, University of Helsinki, Helsinki, Finland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Introduction Treatment outcomes of metastatic melanoma significantly improved after the introduction of immune checkpoint inhibitors (ICIs). By binding to their ligands, they prevent inhibitory signals, enhance the proliferation of T
Janko Sattler
Janko Sattler
Adrenal Steroid Group, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Jinwen Tu
Jinwen Tu
Adrenal Steroid Group, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Shihani Stoner
Shihani Stoner
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
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Jingbao Li
Jingbao Li
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, China
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Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, China
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Frank Buttgereit
Frank Buttgereit
Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Markus J Seibel
Markus J Seibel
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Hong Zhou
Hong Zhou
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
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Mark S Cooper
Mark S Cooper
Adrenal Steroid Group, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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body production of active glucocorticoids from inactive precursors, a measure of systemic 11β-HSD1 activity, is increased in patients with immune-mediated arthritis but can be reduced by anti-tumor necrosis factor α therapy ( 11 , 12 ). 11β-HSD1 is
Zherui Fu
Zherui Fu
Department of Emergency, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
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Yi Lai
Yi Lai
Department of Emergency, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
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Qianfei Wang
Qianfei Wang
Department of Emergency, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
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Feng Lin
Feng Lin
Department of Orthopedics, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
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Jiaping Fang
Jiaping Fang
Department of Emergency, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China
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also analyzed. In addition, the correlation between LRG1 expression and immune infiltration was determined as a possible mechanism for LRG1 involvement in the progression of thyroid cancer. Our results may provide an important target for the
Jiaxin Zhang
Jiaxin Zhang
Department of Traditional Chinese Medicine (TCM) Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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Jinlan Jiang
Jinlan Jiang
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China
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Yao Qin
Yao Qin
School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, China
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Yihui Zhang
Yihui Zhang
Department of Traditional Chinese Medicine (TCM) Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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Yungang Wu
Yungang Wu
Department of Traditional Chinese Medicine (TCM) Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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Huadong Xu
Huadong Xu
School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, China
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apoptosis of bone mesenchymal stem cells and osteoblasts through oxidative stress, which is related to the pathogenesis of osteoporosis ( 8 , 9 ). The systemic immune-inflammation index (SII) is a new inflammatory index based on peripheral blood neutrophils
Natalio García-Honduvilla
Natalio García-Honduvilla
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain
Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
University Center of Defense of Madrid (CUD-ACD), Madrid, Spain
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Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
University Center of Defense of Madrid (CUD-ACD), Madrid, Spain
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Alberto Cifuentes
Alberto Cifuentes
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain
Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
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Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
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Miguel A Ortega
Miguel A Ortega
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain
Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
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Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
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Marta Pastor
Marta Pastor
Biopraxis Research AIE, Álava, Spain
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Garazi Gainza
Garazi Gainza
Biopraxis Research AIE, Álava, Spain
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Eusebio Gainza
Eusebio Gainza
Biopraxis Research AIE, Álava, Spain
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Julia Buján
Julia Buján
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain
Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
University Center of Defense of Madrid (CUD-ACD), Madrid, Spain
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Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
University Center of Defense of Madrid (CUD-ACD), Madrid, Spain
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Melchor Álvarez-Mon
Melchor Álvarez-Mon
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain
Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
University Center of Defense of Madrid (CUD-ACD), Madrid, Spain
Immune System Diseases-Rheumatology and Oncology Service, University Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, Spain
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Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
University Center of Defense of Madrid (CUD-ACD), Madrid, Spain
Immune System Diseases-Rheumatology and Oncology Service, University Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, Spain
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of rhEGF have not been established. Furthermore, the potential effects of the intralesional rhEGF administration in the local inflammatory-immune response remain unknown ( 19 , 20 , 21 ). The aim of the present work was to study of the effects of
