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Greeks and 2% of the refugees had 25OHD levels >30 ng/mL, whereas 19.2% of Greeks and 70.6% of refugees had severe hypovitaminosis D (<10 ng/mL). Likewise, secondary hyperparathyroidism was more prevalent in refugees. There were no statistically
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). According to this criterion, several studies worldwide have shown high rates of hypovitaminosis D, with an estimate of 30–40%, in European, Asian, African and South American countries ( 2 , 3 , 4 ). Therefore, hypovitaminosis D has been listed as a public
Metabolism Laboratory, Department of Endocrinology, School of Medicine and Medical Sciences, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland
Metabolism Laboratory, Department of Endocrinology, School of Medicine and Medical Sciences, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland
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-skeletal health (9, 10, 11, 12, 13) . We started measuring serum 25OHD in 1973 in clinical samples (14) . We conducted a number of clinical studies up to the early 1980s, and noted an extremely high prevalence of hypovitaminosis D in the elderly that was easily
Endocrinology Unit 2, University of Pisa, Pisa, Italy
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, 4 , 5 , 6 ). Indeed, hypovitaminosis D is associated with an increased risk of hypertension, coronary artery disease, ischemic heart disease and stroke. Moreover, it is known that it is involved in the pathophysiology of HF, with different
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-Pietsch B . Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome . European Journal of Endocrinology 2009 161 575 – 582 . ( doi:10.1530/EJE-09-0432 ). 15 Ardabili HR Gargari BP Farzadi L . Vitamin D
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albumin levels. Serum iPTH (RR 1.6–6.9 pmol/L) and 25(OH)D (RR 27.1–107 nmol/L) were measured by electrochemiluminescence assay using commercially available kits (Elecsys 2010 system, Roche Diagnostic). Those having hypovitaminosis D at the time of
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, were overweight or obese, with 340 million children and adolescents aged 5–19 years classified as overweight or obese in 2016 ( 2 ). Micronutrient deficiencies, notably hypovitaminosis D, are common in obese patients ( 3 , 4 ). Extensive
St Michael's Hospital, Metabolism Laboratory, School of Medicine and Medical Sciences, Dún Laoghaire, Dublin, Ireland
St Michael's Hospital, Metabolism Laboratory, School of Medicine and Medical Sciences, Dún Laoghaire, Dublin, Ireland
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/day) administered to institutionalized elderly for 16 months with severe hypovitaminosis D, we noted a dose–response of 9.1 nmol/l (3.6 ng/ml) per 100 IU per day, nearly fourfold higher than the CPG estimate (9, 10) . Using the IOM regression equation, the
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a younger adult population is limited. Vitamin D supplementation increased muscle power in young Arabic women (16) and improved physical performance in a small trial in 40 healthy volunteers with hypovitaminosis D (17) , but not all studies showed
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cells and promotes their apoptosis, preventing their transformation into antigen-presenting cells, which is the first step in the initiation of an immune response ( 9 ). Mice with diet-induced hypovitaminosis D led impaired glucose tolerance, increased