Sofya Gronskaia
Sofya Gronskaia
Endocrinology Research Centre, Moscow, Russia
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Galina Melnichenko
Galina Melnichenko
Endocrinology Research Centre, Moscow, Russia
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Liudmila Rozhinskaya
Liudmila Rozhinskaya
Endocrinology Research Centre, Moscow, Russia
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Tatiana Grebennikova
Tatiana Grebennikova
Endocrinology Research Centre, Moscow, Russia
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Elizaveta Mamedova
Elizaveta Mamedova
Endocrinology Research Centre, Moscow, Russia
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Ekaterina Pigarova
Ekaterina Pigarova
Endocrinology Research Centre, Moscow, Russia
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Elena Przhialkovskaya
Elena Przhialkovskaya
Endocrinology Research Centre, Moscow, Russia
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Larisa Dzeranova
Larisa Dzeranova
Endocrinology Research Centre, Moscow, Russia
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Ivan Dedov
Ivan Dedov
Endocrinology Research Centre, Moscow, Russia
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Valentin Fadeyev
Valentin Fadeyev
I.M. Sechenov First Moscow State Medical University, Moscow, Russia
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Maria Luisa Brandi
Maria Luisa Brandi
University of Florence, Surgery and Translational Medicine, Piereccaini, Firenze, Italy
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Zhanna Belaya
Zhanna Belaya
Endocrinology Research Centre, Moscow, Russia
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Introduction Hypoparathyroidism and pseudohypoparathyroidism (PHP) are rare diseases, which are characterized by hypocalcemia due to low parathyroid hormone (PTH) or resistance to its action ( 1 ). Inadequate PTH levels result in biochemical
Anping Su
Anping Su
Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China
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Yanping Gong
Yanping Gong
Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China
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Wenshuang Wu
Wenshuang Wu
Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China
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Rixiang Gong
Rixiang Gong
Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China
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Zhihui Li
Zhihui Li
Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China
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Jingqiang Zhu
Jingqiang Zhu
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bilateral central neck dissection, always increases the risk of postoperative hypoparathyroidism ( 3 ). The reported incidence in the literature varies from 14 to 51.9% for transient hypoparathyroidism and 0–43% for permanent hypoparathyroidism ( 3 , 4 , 5
Rasmus Reinke
Rasmus Reinke
Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark
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Stefano Christian Londero
Stefano Christian Londero
Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark
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Martin Almquist
Martin Almquist
Department of Surgery, Lund University Hospital, Lund, Sweden
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Lars Rejnmark
Lars Rejnmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Lars Rolighed
Lars Rolighed
Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark
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Total 282 169 86 537 Figure 1 Number of patients with total thyroidectomies in Aarhus University Hospital 2012–2021 and hypoparathyroidism status after 6 months. Figure 2 Total thyroidectomies performed by either
Guido Zavatta
Guido Zavatta
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
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Bart L Clarke
Bart L Clarke
Mayo Clinic, Rochester, Minnesota, USA
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Introduction Over the last 15 years, significant clinical interest has developed in the management of chronic hypoparathyroidism. Until January 2015, chronic hypoparathyroidism was the last major endocrine deficiency without available
A Chinoy
A Chinoy
Royal Manchester Children’s Hospital, Manchester, UK
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M Skae
M Skae
Royal Manchester Children’s Hospital, Manchester, UK
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A Babiker
A Babiker
King Abdullah Specialized Children’s Hospital, Riyadh, Saudi Arabia
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D Kendall
D Kendall
Royal Preston Hospital, Preston, UK
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M Z Mughal
M Z Mughal
Royal Manchester Children’s Hospital, Manchester, UK
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R Padidela
R Padidela
Royal Manchester Children’s Hospital, Manchester, UK
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Introduction Hypoparathyroidism (HPT) is the partial or complete reduction of parathyroid hormone (PTH) secretion from the parathyroid glands. PTH stimulates 1-alpha-hydroxylase enzyme to produce 1,25(OH) 2 -vitamin D, which facilitates active
Jean-Philippe Bertocchio
Jean-Philippe Bertocchio
Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie, Paris, France
Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, INSERM, UMRS1138, Paris, France
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Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, INSERM, UMRS1138, Paris, France
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Natalie Grosset
Natalie Grosset
Hypoparathyroïdisme France, Annecy, France
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Lionel Groussin
Lionel Groussin
Department of Endocrinology, Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Université de Paris, Paris, France
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Peter Kamenický
Peter Kamenický
Université Paris-Saclay, Inserm U1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares du Métabolisme du Calcium et du Phosphate, Le Kremlin-Bicêtre, France
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Fabrice Larceneux
Fabrice Larceneux
Université Paris-Dauphine, PSL Research University, CNRS, UMR 7088, DRM [Ermes], Paris, France
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Anne Lienhardt-Roussie
Anne Lienhardt-Roussie
CHU Dupuytren, Hôpital Mère Enfant, Endocrinologie Pédiatrique, Limoges, France
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Agnès Linglart
Agnès Linglart
Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Université Paris-Saclay, Inserm U1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Service d’Endocrinologie et Diabète de l’Enfant, Centre de Référence des Maladies Rares du Calcium et du Phosphore et Filière de Santé Maladies Rares OSCAR, Hôpital Bicêtre Paris Saclay, Le Kremlin-Bicêtre, France
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Université Paris-Saclay, Inserm U1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Service d’Endocrinologie et Diabète de l’Enfant, Centre de Référence des Maladies Rares du Calcium et du Phosphore et Filière de Santé Maladies Rares OSCAR, Hôpital Bicêtre Paris Saclay, Le Kremlin-Bicêtre, France
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Gérard Maruani
Gérard Maruani
Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie, Paris, France
Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Assistance Publique-Hôpitaux de Paris, Institut Necker-Enfants Malades, INSERM U1151 – CNRS UMR 8253, Paris, France
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Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Assistance Publique-Hôpitaux de Paris, Institut Necker-Enfants Malades, INSERM U1151 – CNRS UMR 8253, Paris, France
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Eric Mirallie
Eric Mirallie
Chirurgie Cancérologique, Digestive et Endocrine, Institut des Maladies de l’Appareil Digestif, Hôtel Dieu, CHU Nantes, France
Association Francophone de Chirurgie Endocrinienne (AFCE), France
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Association Francophone de Chirurgie Endocrinienne (AFCE), France
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François Pattou
François Pattou
Université de Lille, CHU Lille, Institut Pasteur Lille, Inserm U1190, Lille, France
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Riyad N H Seervai
Riyad N H Seervai
Molecular & Cellular Biology Graduate Program, Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas, USA
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Coralie Sido
Coralie Sido
Hypoparathyroïdisme France, Annecy, France
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Caroline Silve
Caroline Silve
Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Biochimie et Génétique Moléculaires, Paris, France
INSERM, U1169, Université Paris Sud, Hôpital Bicêtre, Le Kremlin Bicêtre, France
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Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Biochimie et Génétique Moléculaires, Paris, France
INSERM, U1169, Université Paris Sud, Hôpital Bicêtre, Le Kremlin Bicêtre, France
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Aurélie Vilfaillot
Aurélie Vilfaillot
Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité de Recherche Clinique, Paris, France
INSERM, U1418, CIC-EC, Hôpital Européen Georges Pompidou, Paris, France
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INSERM, U1418, CIC-EC, Hôpital Européen Georges Pompidou, Paris, France
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Antoine Tabarin
Antoine Tabarin
Service Endocrinologie Diabète et Nutrition, CHU de Bordeaux, Université de Bordeaux, Pessac, France
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Marie-Christine Vantyghem
Marie-Christine Vantyghem
CHU Lille, Department of Endocrinology, Diabetology and Metabolism, Inserm U1190, EGID, Lille, France
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Pascal Houillier
Pascal Houillier
Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie, Paris, France
Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, INSERM, UMRS1138, Paris, France
CNRS, ERL8228, Paris, France
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Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, INSERM, UMRS1138, Paris, France
CNRS, ERL8228, Paris, France
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the investigators of the Épi-Hypo study
the investigators of the Épi-Hypo study
the investigators of the Épi-Hypo study
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Introduction Hypoparathyroidism is a rare condition caused by undetectable or inappropriately low secretion of parathyroid hormone (PTH) that is insufficient for maintaining the plasma calcium concentration (PCa) within the normal range ( 1
Marianne C Astor
Marianne C Astor
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Kristian Løvås
Kristian Løvås
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Anette S B Wolff
Anette S B Wolff
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Bjørn Nedrebø
Bjørn Nedrebø
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Eirik Bratland
Eirik Bratland
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Jon Steen-Johnsen
Jon Steen-Johnsen
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Eystein S Husebye
Eystein S Husebye
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Department of Clinical Science, Department of Medicine, Department of Medicine, Pediatric Department, University of Bergen, Bergen, Norway
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Introduction Primary hypoparathyroidism is a rare condition with multiple aetiologies, in adults most commonly caused by damage to the parathyroid glands by surgery or radiation, whereas autoimmune and genetic causes dominate in children
Georgios Kontogeorgos
Georgios Kontogeorgos
Section for Geriatrics and Emergency Medicine, Department of Medicine, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Zoi Mamasoula
Zoi Mamasoula
Section for Geriatrics and Emergency Medicine, Department of Medicine, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Emily Krantz
Emily Krantz
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Penelope Trimpou
Penelope Trimpou
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Section for Endocrinology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Section for Endocrinology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Kerstin Landin-Wilhelmsen
Kerstin Landin-Wilhelmsen
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Section for Endocrinology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Section for Endocrinology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Christine M Laine
Christine M Laine
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Endocrine Out-Patient Clinic, Carlanderska Hospital, Gothenburg, Sweden
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Endocrine Out-Patient Clinic, Carlanderska Hospital, Gothenburg, Sweden
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Introduction Hypoparathyroidism (HypoPT) is a rare endocrine disorder with insufficient levels of parathyroid hormone (PTH), which leads to hypocalcemia and hyperphosphatemia. The phosphate and calcium imbalance increases the risk of ectopic
Julia Herteux
Julia Herteux
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Simon Johannes Geiger
Simon Johannes Geiger
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Christina Starchl
Christina Starchl
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Johanna Windisch
Johanna Windisch
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Theresa Lerchl
Theresa Lerchl
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Adelina Tmava-Berisha
Adelina Tmava-Berisha
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Gerit Wünsch
Gerit Wünsch
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Kathrin Eller
Kathrin Eller
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Astrid Fahrleitner-Pammer
Astrid Fahrleitner-Pammer
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Karin Amrein
Karin Amrein
Medical University of Graz, Auenbruggerplatz, Graz, Austria
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Introduction Background Limited data exist on hospitalizations, emergency room (ER) visits and causes of death in chronic hypoparathyroidism (HP). HP is like a chameleon that can trigger diverse acute and chronic symptoms. The risk for
Cristina Lamas
Cristina Lamas
Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario de Albacete, Albacete, Spain
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Elena Navarro
Elena Navarro
Department of Endocrinology and Nutrition, Hospital Universitario Virgen del Rocío, Sevilla, Spain
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Anna Casterás
Anna Casterás
Department of Endocrinology and Nutrition, Hospital Vall d’Hebron, Barcelona, Spain
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Paloma Portillo
Paloma Portillo
Department of Endocrinology and Nutrition, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
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Victoria Alcázar
Victoria Alcázar
Department of Endocrinology and Nutrition, Hospital Universitario Severo Ochoa, Leganés, Spain
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María Calatayud
María Calatayud
Department of Endocrinology and Nutrition, Hospital Univeristario Doce de Octubre, Madrid, Spain
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Cristina Álvarez-Escolá
Cristina Álvarez-Escolá
Department of Endocrinology and Nutrition, Hospital Universitario La Paz, Madrid, Spain
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Julia Sastre
Julia Sastre
Department of Endocrinology and Nutrition, Complejo Hospitalario de Toledo, Hospital Virgen de la Salud, Toledo, Spain
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Evangelina Boix
Evangelina Boix
Department of Endocrinology and Nutrition, Hospital General Universitario de Elche, Elche, Spain
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Lluis Forga
Lluis Forga
Department of Endocrinology and Nutrition, Complejo Hospitalario de Navarra, Hospital de Navarra, Pamplona, Spain
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Almudena Vicente
Almudena Vicente
Department of Endocrinology and Nutrition, Complejo Hospitalario de Toledo, Hospital Virgen de la Salud, Toledo, Spain
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Josep Oriola
Josep Oriola
Biochemistry and Molecular Genetics Department, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain
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Jordi Mesa
Jordi Mesa
Department of Endocrinology and Nutrition, Hospital Vall d’Hebron, Barcelona, Spain
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Nuria Valdés
Nuria Valdés
Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias, Oviedo, Spain
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after at least 6 months of normal calcium and PTH. Permanent hypoparathyroidism was defined as lasting for more than 6 months. Statistical analysis For the analysis, categorical variables were summarized as frequency counts and percentages
