Sharmin Jahan
Sharmin Jahan
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
Department of Endocrinology and Metabolism, BSMMU, Dhaka, Bangladesh
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Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
Department of Endocrinology and Metabolism, BSMMU, Dhaka, Bangladesh
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Jun Yang
Jun Yang
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
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Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
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Jinbo Hu
Jinbo Hu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Qifu Li
Qifu Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Peter J Fuller
Peter J Fuller
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Victoria, Australia
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.3109/02813432.2011.554015 ) 2 Douma S Petidis K Doumas M Papaefthimiou P Triantafyllou A Kartali N Papadopoulos N Vogiatzis K & Zamboulis C . Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study . Lancet
Kuang Hung
Kuang Hung
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Bo-Ching Lee
Bo-Ching Lee
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Po-Ting Chen
Po-Ting Chen
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Kao-Lang Liu
Kao-Lang Liu
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Chin-Chen Chang
Chin-Chen Chang
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Department and Graduate Institute of Forensic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
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Department and Graduate Institute of Forensic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
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Vin-Cent Wu
Vin-Cent Wu
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Yen-Hung Lin
Yen-Hung Lin
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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BS Auchus R Holt S Watumull L Dolmatch B Nesbitt S Vongpatanasin W Victor R Wians F , Primary hyperaldosteronism: Effect of adrenal vein sampling on surgical outcome . Archives of Surgery 2006 141 497 – 502 . ( https://doi.org/10
Marieke Stientje Velema
Marieke Stientje Velema
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Aline de Nooijer
Aline de Nooijer
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Ad R M M Hermus
Ad R M M Hermus
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Henri J L M Timmers
Henri J L M Timmers
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Jacques W M Lenders
Jacques W M Lenders
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
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Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
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Olga Husson
Olga Husson
Division of Clinical Studies, Institute of Cancer Research, London, UK
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Jaap Deinum
Jaap Deinum
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
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Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
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primary hyperaldosteronism: a cross-sectional study . World Journal of Biological Psychiatry 2014 15 26 – 35 . ( https://doi.org/10.3109/15622975.2012.665480 ) 10.3109/15622975.2012.665480
Yen Kheng Tan
Yen Kheng Tan
Duke-NUS Medical School, SingHealth, Singapore, Singapore
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Yu Heng Kwan
Yu Heng Kwan
Department of Internal Medicine, Singapore General Hospital, Singapore, Singapore
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David Choon Liang Teo
David Choon Liang Teo
Department of Psychological Medicine, Changi General Hospital, Singapore, Singapore
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Marieke Velema
Marieke Velema
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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Jaap Deinum
Jaap Deinum
Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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Pei Ting Tan
Pei Ting Tan
Department of Clinical Trials Research Unit, Changi General Hospital, Singapore, Singapore
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Meifen Zhang
Meifen Zhang
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Joan Joo Ching Khoo
Joan Joo Ching Khoo
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Wann Jia Loh
Wann Jia Loh
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Linsey Gani
Linsey Gani
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Thomas F J King
Thomas F J King
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Eberta Jun Hui Tan
Eberta Jun Hui Tan
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Shui Boon Soh
Shui Boon Soh
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Vanessa Shu Chuan Au
Vanessa Shu Chuan Au
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Tunn Lin Tay
Tunn Lin Tay
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Lily Mae Quevedo Dacay
Lily Mae Quevedo Dacay
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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Keng Sin Ng
Keng Sin Ng
Department of Diagnostic Radiology, Changi General Hospital, Singapore, Singapore
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Kang Min Wong
Kang Min Wong
Department of Diagnostic Radiology, Changi General Hospital, Singapore, Singapore
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Andrew Siang Yih Wong
Andrew Siang Yih Wong
Department of Surgery, Changi General Hospital, Singapore, Singapore
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Foo Cheong Ng
Foo Cheong Ng
Department of Urology, Changi General Hospital, Singapore, Singapore
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Tar Choon Aw
Tar Choon Aw
Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore
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Yvonne Hui Bin Chan
Yvonne Hui Bin Chan
Duke-NUS Medical School, SingHealth, Singapore, Singapore
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Khim Leng Tong
Khim Leng Tong
Department of Cardiology, Changi General Hospital, Singapore, Singapore
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Sheldon Shao Guang Lee
Sheldon Shao Guang Lee
Department of Cardiology, Changi General Hospital, Singapore, Singapore
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Siang Chew Chai
Siang Chew Chai
Department of Cardiology, Changi General Hospital, Singapore, Singapore
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Troy Hai Kiat Puar
Troy Hai Kiat Puar
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
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adrenalectomy leads to normalisation of aldosterone levels, patients on MR antagonists have persistent hyperaldosteronism which may continue to exert harmful effects via non-MR mediated mechanisms ( 29 , 30 ). In addition, there has been evidence of excess
Anna Sjöström
Anna Sjöström
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden
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Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden
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Susanne Rysz
Susanne Rysz
Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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Henrik Sjöström
Henrik Sjöström
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Center for Neurology, Academic Specialist Center, Stockholm, Sweden
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Center for Neurology, Academic Specialist Center, Stockholm, Sweden
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Charlotte Höybye
Charlotte Höybye
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden
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Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden
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Acute systemic diseases, such as severe infections, can lead to electrolyte and acid-base alterations. To study the presence of electrolyte imbalance in severe COVID-19, we investigated the frequency and consequences of changes in electrolyte and acid-base patterns over time. We performed a retrospective cohort study including 406 patients with severe COVID-19. Levels of electrolytes, base excess, pH, serum osmolality, and hematocrit, the first 2 weeks of hospitalization, were collected daily from the laboratory database and clinical data from patients’ medical records. We found that hyponatremia was present in 57% of the patients at admission and 2% in hypernatremia. However, within 2 weeks of hospitalization 42% of the patients developed hypernatremia, more frequently in critically ill patients. Lower levels of sodium and potassium during admission were associated with the need for mechanical ventilation. Decreased pH at admission was associated with both death and the need for mechanical ventilation. Hypernatremia in the ICU was combined with rising base excess and a higher pH. In the group without intensive care, potassium levels were significantly lower in the patients with severe hypernatremia. Presence of hypernatremia during the first 2 weeks of hospitalization was associated with 3.942 (95% CI 2.269–6.851) times higher odds of death. In summary, hypernatremia was common and associated with longer hospital stay and a higher risk of death, suggesting that the dynamics of sodium are an important indicator of severity in COVID-19.
Satoshi Higuchi
Satoshi Higuchi
Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan
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Hideki Ota
Hideki Ota
Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan
Department of Advanced MRI Collaboration Research, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
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Department of Advanced MRI Collaboration Research, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
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Yuta Tezuka
Yuta Tezuka
Division of Nephrology, Endocrinology and Vascular Medicine, Department of Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan
Department of Radiology, The University of British Columbia, Vancouver, Canada
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Department of Radiology, The University of British Columbia, Vancouver, Canada
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Kazumasa Seiji
Kazumasa Seiji
Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan
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Hidenobu Takagi
Hidenobu Takagi
Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan
Department of Radiology, The University of British Columbia, Vancouver, Canada
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Department of Radiology, The University of British Columbia, Vancouver, Canada
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Jongmin Lee
Jongmin Lee
Department of Radiology, School of Medicine, Kyungpook National University, Daegu, Korea
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Yi-Wei Lee
Yi-Wei Lee
Department of Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
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Kei Omata
Kei Omata
Division of Nephrology, Endocrinology and Vascular Medicine, Department of Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan
Department of Radiology, The University of British Columbia, Vancouver, Canada
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Department of Radiology, The University of British Columbia, Vancouver, Canada
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Yoshikiyo Ono
Yoshikiyo Ono
Division of Nephrology, Endocrinology and Vascular Medicine, Department of Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan
Department of Radiology, The University of British Columbia, Vancouver, Canada
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Department of Radiology, The University of British Columbia, Vancouver, Canada
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Ryo Morimoto
Ryo Morimoto
Division of Nephrology, Endocrinology and Vascular Medicine, Department of Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan
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Masataka Kudo
Masataka Kudo
Division of Nephrology, Endocrinology and Vascular Medicine, Department of Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan
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Fumitoshi Satoh
Fumitoshi Satoh
Division of Nephrology, Endocrinology and Vascular Medicine, Department of Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan
Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
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Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
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Kei Takase
Kei Takase
Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan
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essential hypertension (EH) and matched cardiovascular risk profile, resulting in increased cardiovascular mortality ( 9 , 10 ). The two most common causes of PA are unilateral aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA
Takuhiro Sonoyama
Takuhiro Sonoyama
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Masakatsu Sone
Masakatsu Sone
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Naohisa Tamura
Naohisa Tamura
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Kyoko Honda
Kyoko Honda
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Daisuke Taura
Daisuke Taura
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Katsutoshi Kojima
Katsutoshi Kojima
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Yorihide Fukuda
Yorihide Fukuda
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Naotetsu Kanamoto
Naotetsu Kanamoto
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Masako Miura
Masako Miura
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Akihiro Yasoda
Akihiro Yasoda
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Hiroshi Arai
Hiroshi Arai
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Hiroshi Itoh
Hiroshi Itoh
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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Kazuwa Nakao
Kazuwa Nakao
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
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stroke, heart disease, and kidney failure (5, 6) . PA has two major subtypes, aldosterone-producing adenoma (APA), in which aldosterone hypersecretion occurs from a unilateral adrenal adenoma, and idiopathic hyperaldosteronism (IHA), in which aldosterone
Gamze Akkuş
Gamze Akkuş
Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey
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Isa Burak Güney
Isa Burak Güney
Nuclear Medicine Department, Cukurova University Medical Faculty, Adana, Turkey
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Fesih Ok
Fesih Ok
Urology Department, Cukurova University Medical Faculty, Adana, Turkey
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Mehtap Evran
Mehtap Evran
Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey
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Volkan Izol
Volkan Izol
Urology Department, Cukurova University Medical Faculty, Adana, Turkey
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Şeyda Erdoğan
Şeyda Erdoğan
Pathology Department, Cukurova University Medical Faculty, Adana, Turkey
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Yıldırım Bayazıt
Yıldırım Bayazıt
Urology Department, Cukurova University Medical Faculty, Adana, Turkey
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Murat Sert
Murat Sert
Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey
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Tamer Tetiker
Tamer Tetiker
Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey
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hyperaldosteronism, hypercortisolism and pheochromocytoma. Plasma renin/aldosterone ratios, plasma normetanephrine, metanephrines and urinary free cortisol (UFC) were also studied. Autonomous cortisol secretion was described as serum cortisol >1.8 µg/dL following 1
Kristin Viste
Kristin Viste
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Marianne A Grytaas
Marianne A Grytaas
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Melissa D Jørstad
Melissa D Jørstad
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Dag E Jøssang
Dag E Jøssang
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Eivind N Høyden
Eivind N Høyden
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Solveig S Fotland
Solveig S Fotland
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Dag K Jensen
Dag K Jensen
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Kristian Løvås
Kristian Løvås
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Hrafnkell Thordarson
Hrafnkell Thordarson
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Bjørg Almås
Bjørg Almås
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Gunnar Mellgren
Gunnar Mellgren
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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Hormone Laboratory, Department of Medicine, Department of Clinical Science, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway
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College of Cardiology 2006 48 2293 – 2300 . ( doi:10.1016/j.jacc.2006.07.059 ). 3 Fardella CE Mosso L Gomez-Sanchez C Cortes P Soto J Gomez L Pinto M Huete A Oestreicher E Foradori A . Primary hyperaldosteronism in essential
Victor Jing-Wei Kang
Victor Jing-Wei Kang
Departments of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan
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Bo-Ching Lee
Bo-Ching Lee
Departments of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan
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Jia-Zheng Huang
Jia-Zheng Huang
Departments of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan
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Vin-Cent Wu
Vin-Cent Wu
Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
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Yen-Hung Lin
Yen-Hung Lin
Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
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Chin-Chen Chang
Chin-Chen Chang
Departments of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan
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TAIPAI group
TAIPAI group
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-resistant hypertension ( 2 ). Aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) are the two main subtypes of PA ( 3 ). While APA can be cured with unilateral adrenalectomy, IHA is usually managed with pharmacological approaches such as
