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Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Radosław Majewski, Remigiusz Filarski, Magdalena Stefanowicz, Natalia Matulewicz and Marek Strączkowski

catalyzed by the enzyme adipose triglyceride lipase (ATGL), encoded by PNPLA2 . Diacylglycerol is further hydrolyzed to monoacylglycerol and fatty acid with hormone-sensitive lipase (HSL), encoded by LIPE , and monoacylglycerol is ultimately hydrolyzed to

Open access

Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller and Henning Grønbæk

epinephrine) stimulate lipolysis through the actions of adipose triglyceride lipase and hormone-sensitive lipase (HSL), which are rate-limiting enzymes in the conversion of triglycerides into glycerol and FFA. Increased rates of lipolysis elevate circulating

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Julie Smith, Jan Fahrenkrug, Henrik L Jørgensen, Christina Christoffersen and Jens P Goetze

; NPR-C: 5′-tga cac cat tcg gag aat ca, 3′-ttt cac ggt cct cag tag gg; HPRT: 5′-aag ctt gct ggt gaa aag ga, 3′-ttg cgc tca tct tag gct tt; TBP: 5′-taa tcc caa gcg att tgc tgc, 3′-ctt cac atc aca gct ccc ca; hormone-sensitive lipase (HSL): 5′-tgc tct tct

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J Chycki, A Zajac, M Michalczyk, A Maszczyk and J Langfort

circumstances intramuscular TG hydrolysis may at least partially substitute reduced accessibility of NEFA from plasma by adrenaline ( 23 ) and contraction ( 24 ) stimulation of hormone-sensitive lipase (HSL) within muscle cells. It seems that the efficiency of

Open access

Mohammed S Albreiki, Benita Middleton and Shelagh M Hampton

experimental animals ( 18 , 19 ) and humans ( 20 , 21 ). In addition, melatonin has been reported to influence insulin ( 16 ) and glucagon ( 22 ), which in turn affect enzymes involved in lipid metabolism such as hormone-sensitive lipase (HSL) and lipoprotein

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Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey and Christopher J Kenyon

been identified: hormone-sensitive lipase ( Lipe ) ( 11 ) and more recently neutral cholesterol ester hydrolase ( Nceh1 ) ( 33 ). Control of hormone-sensitive lipase activity may be post-translational ( 34 ); Lipe expression is not significantly

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Frederique Van de Velde, Marlies Bekaert, Anja Geerts, Anne Hoorens, Arsène-Hélène Batens, Samyah Shadid, Margriet Ouwens, Yves Van Nieuwenhove and Bruno Lapauw

hepatic inflammation is the component most strongly associated with IR. Several pathophysiological processes might explain these findings. In obesity-related IR, diminished inhibition of hormone-sensitive lipase will lead to enhanced efflux of FFA from

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Hugo R Ramos, Andreas L Birkenfeld and Adolfo J de Bold

disease. cNP have distinct metabolic effects. For instance, cNP exert lipolytic properties mediated by a cGMP-dependent protein kinase G activating pathway. cGMP-activated protein kinase G (GK-I) activates perilipin A and hormone sensitive lipase mediated

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Peter Wolf, Yvonne Winhofer, Martin Krššák and Michael Krebs

, which stimulates the insulin-signaling pathway ( 66 ). In adipose tissue, GH is an important mediator of lipolysis and directly acts on hormone sensitive lipase and enhances the responsiveness for beta-adrenergic activity, which might explain higher

Open access

Pinaki Dutta, Bhuvanesh Mahendran, K Shrinivas Reddy, Jasmina Ahluwalia, Kim Vaiphei, Rakesh K Kochhar, Prakamya Gupta, Anand Srinivasan, Mahesh Prakash, Kanchan Kumar Mukherjee, Viral N Shah, Girish Parthan and Anil Bhansali

levels of HDL-C. This is possibly due to a decrease in lipoprotein lipase activity and increase in hormone-sensitive lipase activity (26, 27) . This study observed a decrease in TGs, cholesterol, and LDL-C levels and an increment in HDL-C after 6-month r