Xiaoyi Qi
Xiaoyi Qi
Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China
Medical College, Shantou University, Shantou, China
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Medical College, Shantou University, Shantou, China
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Liangxian Qiu
Liangxian Qiu
Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China
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Shijia Wang
Shijia Wang
Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China
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Xiongbiao Chen
Xiongbiao Chen
Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China
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Qianwen Huang
Qianwen Huang
Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China
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Yixuan Zhao
Yixuan Zhao
Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China
Medical College, Shantou University, Shantou, China
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Medical College, Shantou University, Shantou, China
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Kunfu Ouyang
Kunfu Ouyang
Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China
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Yanjun Chen
Yanjun Chen
Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China
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Introduction Heart failure (HF) is a complex, multifactorial clinical syndrome characterized by dyspnea and fluid retention caused by impaired systolic or diastolic cardiac function ( 1 , 2 ). In 2017, there were 64.3 million cases of HF
Akinori Sairaku
Akinori Sairaku
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
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Yukiko Nakano
Yukiko Nakano
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
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Yuko Uchimura
Yuko Uchimura
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
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Takehito Tokuyama
Takehito Tokuyama
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
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Hiroshi Kawazoe
Hiroshi Kawazoe
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
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Yoshikazu Watanabe
Yoshikazu Watanabe
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
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Hiroya Matsumura
Hiroya Matsumura
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
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Yasuki Kihara
Yasuki Kihara
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
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-scale cohort studies have shown that subclinical hypothyroidism with a TSH level of ≥10 mIU/L was associated with an increased risk of heart failure ( 7 , 8 ). As major symptoms of heart failure are attributed to an increased left atrial (LA) pressure ( 9
Federica Saponaro
Federica Saponaro
Department of Surgical, Medical, Molecular and Critical Area Pathology, Laboratory of Biochemistry, University of Pisa, Pisa, Italy
Endocrinology Unit 2, University of Pisa, Pisa, Italy
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Endocrinology Unit 2, University of Pisa, Pisa, Italy
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Alessandro Saba
Alessandro Saba
Department of Surgical, Medical, Molecular and Critical Area Pathology, Laboratory of Biochemistry, University of Pisa, Pisa, Italy
Laboratory of Clinical Pathology, University Hospital of Pisa, Pisa, Italy
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Laboratory of Clinical Pathology, University Hospital of Pisa, Pisa, Italy
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Sabina Frascarelli
Sabina Frascarelli
Department of Surgical, Medical, Molecular and Critical Area Pathology, Laboratory of Biochemistry, University of Pisa, Pisa, Italy
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Concetta Prontera
Concetta Prontera
Fondazione Toscana Gabriele Monasterio, Pisa, Italy
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Aldo Clerico
Aldo Clerico
Fondazione Toscana Gabriele Monasterio, Pisa, Italy
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Marco Scalese
Marco Scalese
Institute of Clinical Physiology, National Council of Research, Pisa, Italy
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Maria Rita Sessa
Maria Rita Sessa
Laboratory of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Filomena Cetani
Filomena Cetani
Endocrinology Unit 2, University of Pisa, Pisa, Italy
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Simona Borsari
Simona Borsari
Endocrinology Unit 2, University of Pisa, Pisa, Italy
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Elena Pardi
Elena Pardi
Endocrinology Unit 2, University of Pisa, Pisa, Italy
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Antonella Marvelli
Antonella Marvelli
Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy
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Claudio Marcocci
Claudio Marcocci
Endocrinology Unit 2, University of Pisa, Pisa, Italy
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Claudio Passino
Claudio Passino
Fondazione Toscana Gabriele Monasterio, Pisa, Italy
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Riccardo Zucchi
Riccardo Zucchi
Department of Surgical, Medical, Molecular and Critical Area Pathology, Laboratory of Biochemistry, University of Pisa, Pisa, Italy
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Introduction Heart failure (HF) is a complex and chronic condition and despite advances in therapeutic options, its prognosis remains poor, with high mortality and morbidity. Vitamin D (VitD) has been recently emerged as a factor for HF risk
Jens P Goetze
Jens P Goetze
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Linda M Hilsted
Linda M Hilsted
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Jens F Rehfeld
Jens F Rehfeld
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Urban Alehagen
Urban Alehagen
Department of Clinical Biochemistry, Division of Cardiovascular Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Introduction Heart failure is a syndrome comprising cardiac dysfunction and neurohumoral activation. Medical treatment aims at neutralizing hormonal actions by blocking receptors or inhibiting activation of vasoconstrictive substances. In particular
Ann-Cathrin Koschker
Ann-Cathrin Koschker
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Bodo Warrings
Bodo Warrings
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Caroline Morbach
Caroline Morbach
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Florian Seyfried
Florian Seyfried
Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Nicole Rickert
Nicole Rickert
Department of Radiology, University Hospital, University of Würzburg, Würzburg, Germany
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Pius Jung
Pius Jung
Division of Pneumology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Andreas Geier
Andreas Geier
Division of Hepatology, Department of Internal Medicine II, University Hospital, University of Würzburg, Würzburg, Germany
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Ulrich Dischinger
Ulrich Dischinger
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Maike Krauthausen
Maike Krauthausen
Department of General Practice, University Hospital, University of Würzburg, Würzburg, Germany
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Martin J Herrmann
Martin J Herrmann
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Christine Stier
Christine Stier
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Stefan Frantz
Stefan Frantz
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Uwe Malzahn
Uwe Malzahn
Center for Clinical Trials, University Hospital, University of Würzburg, Würzburg, Germany
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Stefan Störk
Stefan Störk
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Martin Fassnacht
Martin Fassnacht
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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the WAS Study Group
the WAS Study Group
the WAS Study Group
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the risk of new-onset heart failure, particularly heart failure with preserved ejection fraction ( 4 , 5 ). Patients with morbid obesity appear to carry a significantly higher mortality risk ( 6 , 7 ). Currently, bariatric surgery is the only
Paweł Komarnicki
Paweł Komarnicki
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Paweł Gut
Paweł Gut
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Jan Musiałkiewicz
Jan Musiałkiewicz
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Maja Cieślewicz
Maja Cieślewicz
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Adam Maciejewski
Adam Maciejewski
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Prachi Patel
Prachi Patel
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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George Mastorakos
George Mastorakos
Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Marek Ruchała
Marek Ruchała
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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hormone secretion (predominantly serotonin), which leads to the formation of fibrous, plaque-like deposits on the patient’s endocardium and heart valves. Progressive deformation of the valves results in heart failure, usually right-sided ( 19 ). N
Ulrik Ø Andersen
Ulrik Ø Andersen
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Dijana Terzic
Dijana Terzic
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Nicolai Jacob Wewer Albrechtsen
Nicolai Jacob Wewer Albrechtsen
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Peter Dall Mark
Peter Dall Mark
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Peter Plomgaard
Peter Plomgaard
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Jens F Rehfeld
Jens F Rehfeld
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
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Finn Gustafsson
Finn Gustafsson
Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
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Jens P Goetze
Jens P Goetze
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Introduction Chronic heart failure is treated by inhibition of the sympathetic and the renin-angiotensin-aldosterone system (RAAS). More recently, sacubitril/valsartan has been introduced as treatment for patients with chronic heart failure
Marie Oertel
Marie Oertel
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
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Christian G Ziegler
Christian G Ziegler
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
Department of Internal Medicine III, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
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Department of Internal Medicine III, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
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Michael Kohlhaas
Michael Kohlhaas
Comprehensive Heart Failure Center, Würzburg, Germany
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Alexander Nickel
Alexander Nickel
Comprehensive Heart Failure Center, Würzburg, Germany
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Simon Kloock
Simon Kloock
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
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Christoph Maack
Christoph Maack
Comprehensive Heart Failure Center, Würzburg, Germany
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Vasco Sequeira
Vasco Sequeira
Comprehensive Heart Failure Center, Würzburg, Germany
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Martin Fassnacht
Martin Fassnacht
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
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Ulrich Dischinger
Ulrich Dischinger
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, Würzburg, Germany
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Comprehensive Heart Failure Center, Würzburg, Germany
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.1056/NEJMsr1606602 ) 7 Pandey A LaMonte M Klein L Ayers C Psaty BM Eaton CB Allen NB Lemos de JA Carnethon M Greenland P , et al. Relationship between physical activity, body mass index, and risk of heart failure . Journal of the
Hugo R Ramos
Hugo R Ramos
Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
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Andreas L Birkenfeld
Andreas L Birkenfeld
Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
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Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
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Adolfo J de Bold
Adolfo J de Bold
Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
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correlate with an increase in plasma cNP in heart failure (5, 6) . However, studies on cardiac transplant patients have shown that plasma cNP levels remain high even after intra-cardiac pressures normalize following transplantation (7) . During an acute
Thera P Links
Thera P Links
Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Trynke van der Boom
Trynke van der Boom
Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Wouter T Zandee
Wouter T Zandee
Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Joop D Lefrandt
Joop D Lefrandt
Division of Vascular Medicine, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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increased mortality in overt hyperthyroidism can be explained by both heart failure and atrial fibrillation. In overt hyperthyroidism, congestive circulation results in high output failure. In addition, the associated atrial fibrillation may increase the
