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could be perceived as prejudicing the impartiality of this guideline. Funding This work did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. Disclaimer The document should be
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Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Ruperto-Carola University of Heidelberg, Heidelberg, Germany
Synlab Medical Center of Human Genetics Mannheim, Mannheim, Germany
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) 2017 Clinical Practice Guideline’ that vitamin D deficiency and insufficiency be corrected by vitamin D supplementation using treatment strategies recommended for the general population ( 107 ). Parathyroid diseases also require particular attention
St Michael's Hospital, Metabolism Laboratory, School of Medicine and Medical Sciences, Dún Laoghaire, Dublin, Ireland
St Michael's Hospital, Metabolism Laboratory, School of Medicine and Medical Sciences, Dún Laoghaire, Dublin, Ireland
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Introduction Two conflicting reports on vitamin D intake requirements were published in 2011: Institute of Medicine (IOM) report on Dietary Reference Intakes for Calcium and Vitamin D and the Endocrine Society's Clinical Practice Guideline (CPG
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Amsterdam UMC, Emma’s Children’s Hospital, Amsterdam, The Netherlands
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guideline-based care and standardized transition processes may now in turn motivate these existing structures to develop further the long-term care of chronically ill patients. Our initial knowledge about late effects resulted from LTFU of patients
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
School of Nursing and Midwifery, Institute of Clinical Sciences, University of Birmingham, UK
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Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
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Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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those who had been on treatment for at least 5 years ( Table 2 ). Only 6.2% ( n = 4) indicated that they had a guideline/protocol to guide discontinuation of long-term GH treatment in adults, whereas for the majority (90.8% ( n = 59)), such guideline
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or hemorrhage Yes Diabetes Technology Society Consensus Guideline (US) ( 11 ) - All hospitalized patients TBR <80–85 mg/dL - BG <40 mg/dL or > 500 mg/dL - Hyperglycemic crisis - Situations with rapidly changing glucose levels and fluid
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.94–0.99) for the diagnosis of unilateral PA, possibly due to their florid presentations ( 18 ). For people in whom confirmation testing is required, the Endocrine Society’s clinical practice guideline recommends four confirmatory tests, including the
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University Hospital Würzburg, Department of Nuclear Medicine, Würzburg, Germany
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2018, the International Guideline Harmonization Group (IGHG) on guidelines for late effects of childhood cancer, therefore, released recommendations on surveillance for DTC in at-risk CCS ( 6 ). These guidelines stated that surveillance for DTC may be
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Aim
We aim to investigate the clinical characteristics of the rectal NECs and the prognosis-related factors and construct a nomogram for prognosis prediction.
Methods
The data of 41 patients and 1028 patients with rectal NEC were retrieved respectively from our institution and SEER database. OS or PFS was defined as the major study outcome. Variables were compared by chi-square test and t-test when appropriate. Kaplan–Meier analysis with log-rank test was used for survival analysis and the Cox regression analysis was applied. The nomogram integrating risk factors for predicting OS was constructed by R to achieve superior discriminatory ability. Predictive utility of the nomogram was determined by concordance index (C-index) and calibration curve.
Results
In the univariate and multivariate analyses, tumor differentiation, N stage, M stage and resection of primary site were identified as independent prognostic indicators. The linear regression relationship was found between the value of Ki-67 index and the duration of OS (P < 0.05). Furthermore, the independent prognostic factors were added to formulate prognostic nomogram. The constructed nomogram showed good performance according to the C-index.
Conclusions
Contrary to WHO classification guideline, we found that the rectal NEC diseases are heterogeneous and should be divided as different categories according to the pathological differentiation. Besides, the nomogram formulated in this study showed excellent discriminative capability to predict OS for those patients. More advanced predictive model for this disease is required to assist risk stratification via the formulated nomogram.
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this guideline is Professor Weibke Arlt who was also an author on the Endocrine Society Clinical Practice Guideline and the diagnosis and treatment of primary adrenal insufficiency published in 2016 ( 2 ). Severe symptomatic hyponatraemia ( 3 ): this
