Search Results

You are looking at 1 - 10 of 272 items for :

  • "growth hormone" x
Clear All
Sherwin Criseno Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
School of Nursing and Midwifery, Institute of Clinical Sciences, University of Birmingham, UK

Search for other papers by Sherwin Criseno in
Google Scholar
PubMed
Close
,
Helena Gleeson Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

Search for other papers by Helena Gleeson in
Google Scholar
PubMed
Close
,
Andrew A Toogood Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

Search for other papers by Andrew A Toogood in
Google Scholar
PubMed
Close
,
Neil Gittoes Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

Search for other papers by Neil Gittoes in
Google Scholar
PubMed
Close
,
Anne Topping School of Nursing and Midwifery, Institute of Clinical Sciences, University of Birmingham, UK

Search for other papers by Anne Topping in
Google Scholar
PubMed
Close
, and
Niki Karavitaki Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

Search for other papers by Niki Karavitaki in
Google Scholar
PubMed
Close

Introduction Growth hormone deficiency (GHD) is a clinical condition that can present in childhood or adult life. Adult-onset GHD is usually caused by a pituitary tumour and/or its treatments (surgery, radiotherapy) ( 1 ). Although the true

Open access
María L Bacigalupo Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

Search for other papers by María L Bacigalupo in
Google Scholar
PubMed
Close
,
Verónica G Piazza Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

Search for other papers by Verónica G Piazza in
Google Scholar
PubMed
Close
,
Nadia S Cicconi Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

Search for other papers by Nadia S Cicconi in
Google Scholar
PubMed
Close
,
Pablo Carabias Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

Search for other papers by Pablo Carabias in
Google Scholar
PubMed
Close
,
Andrzej Bartke Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA

Search for other papers by Andrzej Bartke in
Google Scholar
PubMed
Close
,
Yimin Fang Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA

Search for other papers by Yimin Fang in
Google Scholar
PubMed
Close
,
Ana I Sotelo Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

Search for other papers by Ana I Sotelo in
Google Scholar
PubMed
Close
,
Gabriel A Rabinovich Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, and Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

Search for other papers by Gabriel A Rabinovich in
Google Scholar
PubMed
Close
,
María F Troncoso Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

Search for other papers by María F Troncoso in
Google Scholar
PubMed
Close
, and
Johanna G Miquet Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

Search for other papers by Johanna G Miquet in
Google Scholar
PubMed
Close

, alcohol abuse or nonalcoholic steatohepatitis. Regardless of the carcinogenic insult, it usually develops in patients with cirrhosis due to chronic inflammation and advanced fibrosis ( 2 ). Growth hormone (GH) is a major regulator of body growth and

Open access
Jin Kyu Oh Department of Urology, College of Medicine, Gachon University, Incheon, Republic of Korea

Search for other papers by Jin Kyu Oh in
Google Scholar
PubMed
Close
,
Young Jae Im Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea

Search for other papers by Young Jae Im in
Google Scholar
PubMed
Close
,
Kwanjin Park Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea

Search for other papers by Kwanjin Park in
Google Scholar
PubMed
Close
, and
Jae-Seung Paick Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea

Search for other papers by Jae-Seung Paick in
Google Scholar
PubMed
Close

frequent causes include growth hormone (GH) deficiencies and idiopathic functional abnormalities of the hypothalamic–pituitary–testicular axis, and overt abnormalities are generally absent under these conditions ( 2 , 3 ). Patients with micropenis are

Open access
Caiyan Mo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Search for other papers by Caiyan Mo in
Google Scholar
PubMed
Close
,
Tao Tong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Search for other papers by Tao Tong in
Google Scholar
PubMed
Close
,
Ying Guo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Search for other papers by Ying Guo in
Google Scholar
PubMed
Close
,
Zheng Li Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Search for other papers by Zheng Li in
Google Scholar
PubMed
Close
, and
Liyong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Search for other papers by Liyong Zhong in
Google Scholar
PubMed
Close

Introduction Growth hormone-secreting pituitary adenoma (GHPA) is due to the overproduction of growth hormone (GH) by pituitary adenomas, which stimulates the liver to produce insulin-like growth factor 1 (IGF-1), and the long

Open access
Mette Marie Baunsgaard Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

Search for other papers by Mette Marie Baunsgaard in
Google Scholar
PubMed
Close
,
Anne Sophie Lind Helligsoe Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

Search for other papers by Anne Sophie Lind Helligsoe in
Google Scholar
PubMed
Close
,
Louise Tram Henriksen Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

Search for other papers by Louise Tram Henriksen in
Google Scholar
PubMed
Close
,
Torben Stamm Mikkelsen Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

Search for other papers by Torben Stamm Mikkelsen in
Google Scholar
PubMed
Close
,
Michael Callesen Department of Paediatrics, Odense University Hospital, Odense, Funen, Denmark

Search for other papers by Michael Callesen in
Google Scholar
PubMed
Close
,
Britta Weber The Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark

Search for other papers by Britta Weber in
Google Scholar
PubMed
Close
,
Henrik Hasle Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

Search for other papers by Henrik Hasle in
Google Scholar
PubMed
Close
, and
Niels Birkebæk Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

Search for other papers by Niels Birkebæk in
Google Scholar
PubMed
Close

physical chronic late effects ( 15 ) with growth hormone deficiency (GHD) being the most common endocrinopathy ( 16 ) followed by thyroid-stimulating hormone deficiency ( 17 ). CR is the most significant risk factor for the development of GHD ( 18

Open access
Alicia Romano Department of Pediatrics, New York Medical College, Valhalla, New York, USA

Search for other papers by Alicia Romano in
Google Scholar
PubMed
Close
,
Juan Pablo Kaski Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital & UCL Institute of Cardiovascular Science, London, UK

Search for other papers by Juan Pablo Kaski in
Google Scholar
PubMed
Close
,
Jovanna Dahlgren Department of Paediatrics, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Jovanna Dahlgren in
Google Scholar
PubMed
Close
,
Nicky Kelepouris US Medical Affairs, Novo Nordisk Inc., Plainsboro, New Jersey, USA

Search for other papers by Nicky Kelepouris in
Google Scholar
PubMed
Close
,
Alberto Pietropoli Global Medical Affairs, Novo Nordisk Health Care AG, Zurich, Switzerland

Search for other papers by Alberto Pietropoli in
Google Scholar
PubMed
Close
,
Tilman R Rohrer Department of Pediatric Endocrinology, University Children’s Hospital, Saarland University Medical Center, Homburg, Germany

Search for other papers by Tilman R Rohrer in
Google Scholar
PubMed
Close
, and
Michel Polak Paediatric Endocrinology, Diabetology and Gynaecology Department, Hôpital Universitaire Necker Enfants-Malades, AP-HP, Université de Paris, Imagine Institute, Paris, France

Search for other papers by Michel Polak in
Google Scholar
PubMed
Close

stenosis (PVS; prevalence 50–60%), hypertrophic cardiomyopathy (HCM; 20%) and atrial septal defects (6–10%) ( 1 ). Growth hormone (GH) treatment in patients with NS improves height velocity, height standard deviation score (SDS) and adult height, with a

Open access
Alessandro Ciresi Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

Search for other papers by Alessandro Ciresi in
Google Scholar
PubMed
Close
,
Stefano Radellini Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

Search for other papers by Stefano Radellini in
Google Scholar
PubMed
Close
,
Valentina Guarnotta Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

Search for other papers by Valentina Guarnotta in
Google Scholar
PubMed
Close
,
Maria Grazia Mineo Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

Search for other papers by Maria Grazia Mineo in
Google Scholar
PubMed
Close
, and
Carla Giordano Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

Search for other papers by Carla Giordano in
Google Scholar
PubMed
Close

one of the most influential regulators of growth hormone (GH) secretion and action, with different mechanisms ( 2 ). Androgens and estrogens exert opposite endocrine-mediated effects on insulin-like growth factor (IGF)-I production and metabolic

Open access
Alexander A L Jorge Unidade de Endocrinologia-Genetica, LIM/25, Disciplina de Endocrinologia da Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), Sao Paulo, Brazil

Search for other papers by Alexander A L Jorge in
Google Scholar
PubMed
Close
,
Thomas Edouard Endocrine, Bone Diseases, and Genetics Unit, Children’s Hospital, Toulouse University Hospital, RESTORE INSERM UMR1301, Toulouse, France

Search for other papers by Thomas Edouard in
Google Scholar
PubMed
Close
,
Mohamad Maghnie Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy

Search for other papers by Mohamad Maghnie in
Google Scholar
PubMed
Close
,
Alberto Pietropoli Novo Nordisk Health Care AG, Global Medical Affairs Biopharm, Zürich, Switzerland

Search for other papers by Alberto Pietropoli in
Google Scholar
PubMed
Close
,
Nicky Kelepouris Novo Nordisk Inc., Clinical, Medical and Regulatory Biopharm-RED, Plainsboro, New Jersey, USA

Search for other papers by Nicky Kelepouris in
Google Scholar
PubMed
Close
,
Alicia Romano Department of Pediatrics, New York Medical College, Valhalla, New York, USA

Search for other papers by Alicia Romano in
Google Scholar
PubMed
Close
,
Martin Zenker Institute of Human Genetics & Department of Pediatrics, University Hospital, Otto-von-Guericke University Magdeburg, Magdeburg, Germany

Search for other papers by Martin Zenker in
Google Scholar
PubMed
Close
, and
Reiko Horikawa Department of Endocrine and Metabolism, National Center for Child Health and Development, Tokyo, Japan

Search for other papers by Reiko Horikawa in
Google Scholar
PubMed
Close

addition, puberty is often delayed and is accompanied by a delay in bone age ( 1 , 9 , 11 ). It is estimated that over 50% of females and almost 40% of males with NS have an adult height below the third percentile ( 1 ). Abnormalities of growth hormone

Open access
Gudmundur Johannsson Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Search for other papers by Gudmundur Johannsson in
Google Scholar
PubMed
Close
,
Martin Bidlingmaier Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany

Search for other papers by Martin Bidlingmaier in
Google Scholar
PubMed
Close
,
Beverly M K Biller Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA

Search for other papers by Beverly M K Biller in
Google Scholar
PubMed
Close
,
Margaret Boguszewski Federal University of Parana, Curitiba, Brazil

Search for other papers by Margaret Boguszewski in
Google Scholar
PubMed
Close
,
Felipe F Casanueva Department of Medicine, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain

Search for other papers by Felipe F Casanueva in
Google Scholar
PubMed
Close
,
Philippe Chanson Assistance Publique-Hôpitaux de Paris, and Inserm, Paris, France

Search for other papers by Philippe Chanson in
Google Scholar
PubMed
Close
,
Peter E Clayton Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK

Search for other papers by Peter E Clayton in
Google Scholar
PubMed
Close
,
Catherine S Choong Department of Endocrinology, Princess Margaret Hospital & School of Medicine, University of Western Australia, Western Australia, Australia

Search for other papers by Catherine S Choong in
Google Scholar
PubMed
Close
,
David Clemmons Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA

Search for other papers by David Clemmons in
Google Scholar
PubMed
Close
,
Mehul Dattani Great Ormond Street Institute of Child Health, London, UK

Search for other papers by Mehul Dattani in
Google Scholar
PubMed
Close
,
Jan Frystyk Department of Endocrinology, Odense University Hospital, Odense, Denmark

Search for other papers by Jan Frystyk in
Google Scholar
PubMed
Close
,
Ken Ho Princess Alexandra Hospital and University of Queensland, Brisbane, Australia

Search for other papers by Ken Ho in
Google Scholar
PubMed
Close
,
Andrew R Hoffman Department of Medicine, Stanford University and VA Palo Health Care System, Palo Alto, California, USA

Search for other papers by Andrew R Hoffman in
Google Scholar
PubMed
Close
,
Reiko Horikawa National Center for Child Health and Development, Tokyo, Japan

Search for other papers by Reiko Horikawa in
Google Scholar
PubMed
Close
,
Anders Juul Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Anders Juul in
Google Scholar
PubMed
Close
,
John J Kopchick Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA

Search for other papers by John J Kopchick in
Google Scholar
PubMed
Close
,
Xiaoping Luo Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Search for other papers by Xiaoping Luo in
Google Scholar
PubMed
Close
,
Sebastian Neggers Section of Endocrinology, Department of Medicine, Pituitary Centre Rotterdam, Erasmus University Medical Centre, Rotterdam, the Netherlands

Search for other papers by Sebastian Neggers in
Google Scholar
PubMed
Close
,
Irene Netchine Service d’Explorations Fonctionnelles Endocriniennes, AP-HP, Hôpital Trousseau, Sorbonne Université, INSERM UMRs 938, Paris, France

Search for other papers by Irene Netchine in
Google Scholar
PubMed
Close
,
Daniel S Olsson Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Daniel S Olsson in
Google Scholar
PubMed
Close
,
Sally Radovick Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

Search for other papers by Sally Radovick in
Google Scholar
PubMed
Close
,
Ron Rosenfeld Department of Pediatrics, Oregon Health Science University, Portland, Oregon, USA

Search for other papers by Ron Rosenfeld in
Google Scholar
PubMed
Close
,
Richard J Ross University of Sheffield, Sheffield, UK

Search for other papers by Richard J Ross in
Google Scholar
PubMed
Close
,
Katharina Schilbach Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany

Search for other papers by Katharina Schilbach in
Google Scholar
PubMed
Close
,
Paulo Solberg Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

Search for other papers by Paulo Solberg in
Google Scholar
PubMed
Close
,
Christian Strasburger Charité-Universitätsmedizin, Berlin, Germany

Search for other papers by Christian Strasburger in
Google Scholar
PubMed
Close
,
Peter Trainer The Christie NHS Foundation Trust, University of Manchester, Manchester, UK

Search for other papers by Peter Trainer in
Google Scholar
PubMed
Close
,
Kevin C J Yuen Barrow Pituitary Center, Barrow Neurological Institute, Department of Neuroendocrinology, University of Arizona College of Medicine, Phoenix, Arizona, USA

Search for other papers by Kevin C J Yuen in
Google Scholar
PubMed
Close
,
Kerstin Wickstrom Medical Products Agency, Uppsala, Sweden

Search for other papers by Kerstin Wickstrom in
Google Scholar
PubMed
Close
,
Jens O L Jorgensen Aarhus University Hospital, Aarhus, Denmark

Search for other papers by Jens O L Jorgensen in
Google Scholar
PubMed
Close
, and
on behalf of the Growth Hormone Research Society
Search for other papers by on behalf of the Growth Hormone Research Society in
Google Scholar
PubMed
Close

). The requirement for rigorous procedures utilizing biomarkers in drug development is evident and recognized ( 2 , 5 ). The obvious biomarkers of growth hormone (GH) action in children and adults are serum levels of GH itself and of insulin-like growth

Open access
Sarmistha Banerjee Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Search for other papers by Sarmistha Banerjee in
Google Scholar
PubMed
Close
,
Allison M Hayes Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Search for other papers by Allison M Hayes in
Google Scholar
PubMed
Close
, and
Bernard H Shapiro Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Search for other papers by Bernard H Shapiro in
Google Scholar
PubMed
Close

of CYP3A4 and CYP3A5 ( 3 , 4 ) while in the case of mice, males express greater levels of CYP2D9 ( 2 ). (ii) The sexual dimorphisms in CYP expression are determined by sex differences in the circulating growth hormone (GH) profiles in adulthood. More

Open access