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Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen and on behalf of the Growth Hormone Research Society

). The requirement for rigorous procedures utilizing biomarkers in drug development is evident and recognized ( 2 , 5 ). The obvious biomarkers of growth hormone (GH) action in children and adults are serum levels of GH itself and of insulin-like growth

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María L Bacigalupo, Verónica G Piazza, Nadia S Cicconi, Pablo Carabias, Andrzej Bartke, Yimin Fang, Ana I Sotelo, Gabriel A Rabinovich, María F Troncoso and Johanna G Miquet

, alcohol abuse or nonalcoholic steatohepatitis. Regardless of the carcinogenic insult, it usually develops in patients with cirrhosis due to chronic inflammation and advanced fibrosis ( 2 ). Growth hormone (GH) is a major regulator of body growth and

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Jin Kyu Oh, Young Jae Im, Kwanjin Park and Jae-Seung Paick

frequent causes include growth hormone (GH) deficiencies and idiopathic functional abnormalities of the hypothalamic–pituitary–testicular axis, and overt abnormalities are generally absent under these conditions ( 2 , 3 ). Patients with micropenis are

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Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Maria Grazia Mineo and Carla Giordano

one of the most influential regulators of growth hormone (GH) secretion and action, with different mechanisms ( 2 ). Androgens and estrogens exert opposite endocrine-mediated effects on insulin-like growth factor (IGF)-I production and metabolic

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Werner F Blum, Abdullah Alherbish, Afaf Alsagheir, Ahmed El Awwa, Walid Kaplan, Ekaterina Koledova and Martin O Savage

Introduction The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is the principle endocrine system regulating linear growth in children ( 1 ). Linked to the nutritional status of the individual, GH is a potent stimulator of IGF

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Kennett Sprogøe, Eva Mortensen, David B Karpf and Jonathan A Leff

Introduction Following secretion from the anterior pituitary, human growth hormone (GH) is transported throughout the body, exerting its effects via GH receptors on virtually every cell of the body. In addition to muscle and bone growth, GH is

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M Ahmid, C G Perry, S F Ahmed and M G Shaikh

Introduction Growth hormone deficiency (GHD) is an endocrine condition that can potentially impact on an individual’s life from childhood, adolescence to young adulthood and beyond. In UK, the prevalence of congenital childhood-onset GHD (CO

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Charlotte Höybye, Andreas F H Pfeiffer, Diego Ferone, Jens Sandahl Christiansen, David Gilfoyle, Eva Dam Christoffersen, Eva Mortensen, Jonathan A Leff and Michael Beckert

Introduction Hypothalamic–pituitary diseases and/or injury can lead to adult growth hormone deficiency (AGHD) ( 1 ). The decrease (or total loss) of growth hormone (GH) production, with a subsequent disruption in the hormone’s relationship

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Imane Benabbad, Myriam Rosilio, Maité Tauber, Emmanuel Paris, Anne Paulsen, Lovisa Berggren, Hiren Patel, Jean-Claude Carel and the Phoenix Study Group

cause short stature have been excluded ( 1 ). Various studies have shown that growth hormone (GH) treatment of children with ISS can increase their growth velocity and, to a lesser extent, adult height ( 1 , 2 , 3 , 4 , 5 , 6 ). The effect on height

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Anna-Pauliina Iivonen, Johanna Känsäkoski, Atte Karppinen, Leena Kivipelto, Camilla Schalin-Jäntti, Auli Karhu and Taneli Raivio

have huge social significance and they can predict adult life health and reproductive success ( 1 , 2 ). Growth hormone (GH), which is secreted from the anterior pituitary somatotroph cells, regulates human growth under the influence of hypothalamic