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Qi Zhang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Hongshan Wang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yanhong Xie Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Suming Huang Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Ke Chen Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Botian Ye Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yupeng Yang Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Jie Sun Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Hongyong He Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Fenglin Liu Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Zhenbin Shen Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Weidong Chen Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Kuntang Shen Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Yuan Ji Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Yihong Sun Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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challenged after several studies reported that some cases of high-grade GEP-NENs also presented a well-differentiated pattern ( 5 , 6 ). NORDIC study also reported heterogeneity in high-grade GEP-NENs ( 7 ). Thus, the concept of grade 3 neuroendocrine tumor

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Xu Han Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Xuefeng Xu Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Hongyun Ma Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China

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Yuan Ji Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Dansong Wang Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Tiantao Kuang Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Wenchuan Wu Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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Bin Song Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China

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Gang Li Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China

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Gang Jin Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China

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Wenhui Lou Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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-8674(01)00459-7 ) 23 Coriat R Walter T Terris B Couvelard A Ruszniewski P . Gastroenteropancreatic well-differentiated grade 3 neuroendocrine tumors: review and position statement . Oncologist 2016 21 1191 – 1199 . ( https://doi.org/10.1634/theoncologist.2015

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