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). Clinical features include small penis, scrotal hypoplasia and cryptorchidism at birth, with spontaneous puberty but mid-pubertal arrest and reduced testicular volume attributable to a reduction in seminiferous tubules. Basal gonadotrophins and testosterone
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). Oestrogens, although present in much smaller concentrations compared to androgens, have strong suppressive effects on gonadotrophin production ( 10 ). Anti-oestrogens, such as tamoxifen and clomiphene citrate, have been shown to stimulate gonadotrophin and
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amount of gonadotrophins, number of oocytes retrieved, number of M2, normal fertilization (2PN), number of transferred embryos, number of embryos available to freeze, embryo grade and morphokinetic scores and morphokinetic parameters by hours from
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Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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. Placental biomarkers such as soluble fms-like tyrosine kinase-1 (sFLT), human chorionic gonadotrophin (hCG), and placental growth factor (PLGF) are known to be important representatives of placental (dys)function ( 21 ). These biomarkers have been associated
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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-Mullerian hormone (AMH) and inhibin B levels, which were analysed by ELISA after transportation to the Protein Reference Unit in Sheffield Gonadotrophin function – luteinising hormone (LH) and follicle-stimulating hormone (FSH) concentrations as previously
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Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Robert-Debré, Department of Pediatric Endocrinology and Diabetology, and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Paris, France
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of ISS are often referred late, with GH treatment initiated when puberty has already started. Gonadotrophin-releasing hormone (GnRH) agonists administered alone for 2–3 years in this patient population delay puberty and epiphyseal closure but decrease
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Faculty of Life Sciences and Medicine, School of Life Course Sciences, King’s College London, London, UK
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Quebec Heart and Lung Institute, Laval University, Quebec, Canada
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Barts and the London School of Medicine, Centre for Endocrinology, William Harvey Institute, London, UK
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Obesity, Type 2 Diabetes and Immunometabolism Research Group, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Course Sciences, King’s College London, London, UK
Division of Reproductive Health, Warwick Medical School, University of Warwick, Coventry, UK
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), adrenocorticotrophic hormone (ACTH), cortisol-binding globulin (CBG), thyroxine-binding globulin (TBG), gonadotrophins, DHEAS, testosterone and plasma EDTA ACTH were collected using BD Vacutainer during the same venepuncture. Samples were stored at −80°C until analysis
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triptorelin, leuprolide and goserelin are used as ADT ( 4 ). More recently, gonadotrophin-releasing hormone (GnRH) antagonists such as degarelix and relugolix have been developed ( 1 , 5 ). At present, ‘Standard of Care’ for advanced or metastatic PCa is ADT
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’s correlation. The relationships among MKRN3, kisspeptin, and gonadotrophins were assessed by using Spearman’s rank-order. P value less than 0.05 was considered to be statistically significant. A receiver operating characteristic (ROC) was constructed for
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testicular development and function Secretion of gonadotrophins, luteinising hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary gland is responsible for regulating hormonal control of the testis in the male. LH and FSH signal through