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such patients ( 6 ). Because receiving RAI may threaten male patients’ testicular function and even affect fertility, it is crucial to understand the impact of RAI on gonadal function in this population. Although previous domestic and foreign studies
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Hematology Department, Fundeni Hospital, Bucharest, Romania
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Endocrine Department, Elias Hospital, Bucharest, Romania
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following HSCT results in a spectrum of gonadal function with varied clinical outcomes ( 5 ). Ovarian failure after HSCT has been observed in 65–84% of transplant recipients ( 5 , 12 , 13 , 14 ). In patients performing HSCT for hematological malignancies
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total body irradiation (TBI) ( 2 ). Studies addressing gonadal function in pediatric HSCT survivors are highly needed, as these patients experience an insult to the reproductive axis during the critical developmental stages of life, compromising direct
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Pediatric Endocrinology Clinic, Department of Pediatrics, Aretaeio Hospital, Nicosia, Cyprus
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Department of Clinical Medicine, University of Copenhagen, Denmark
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; however, adult patients with CAH often experience inadequate treatment with health sequelae including an impaired gonadal function ( 3 ). One of the most important testicular complications in male patients with CAH is the development of testicular
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cell cancer (HNSCC) at the time of AMH testing. In total, eight of the nine patients with FA had either hypogonadism, had undergone HCT, or both ( Table 2 ). Several other conditions that might have impacted gonadal function included pituitary stalk
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gonadotropin (hCG) is frequently used to start or maintain spermatogenesis and endogenous testosterone production. Although it is effective to stimulate gonadal function, it does not stimulate gonadotrophin production. It may actually delay recovery of
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
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Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
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Department of Endocrinology and Reproductive Medicine, AP-HPIE3M, Hôpital Pitié-Salpêtrière, ICAN, Paris, France
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Department of Endocrinology and Reproductive Medicine, AP-HPIE3M, Hôpital Pitié-Salpêtrière, ICAN, Paris, France
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Centre for Rare Gynecological Disorders, Hospital Universitaire Necker-Enfants Malades, Paediatric Endocrinology, Gynaecology and Diabetology, AP-HP, Université de Paris, Paris, France
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Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Centre for Rare Gynecological Disorders, Hospital Universitaire Necker-Enfants Malades, Paediatric Endocrinology, Gynaecology and Diabetology, AP-HP, Université de Paris, Paris, France
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Xu YK Ng WG Silva PD Lobo RA Donnell GN Gonadal function and ovarian galactose metabolism in classic galactosemia . Acta Endocrinologica 1989 120 129 – 133 . ( https://doi.org/10.1530/acta.0.1200129 ) 14 Xu YK Ng WG Kaufman FR
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after weighing the adequacy of residual gonadal function to preserve fertility and avoid the need for hormone replacement and the potential for gender dysphoria against the risk of production of opposite sex hormones and missing the early diagnosis of
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– 2037 . ( https://doi.org/10.1093/humrep/dev158 ) 10.1093/humrep/dev158 8 De Rosa M Colao A Di SA Ferone D Landi ML Zarrilli S Paesano L Merola B Lombardi G. Cabergoline treatment rapidly improves gonadal function in hyperprolactinemic males: a
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Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Edinburgh Royal Hospital for Sick Children, Edinburgh, UK
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– 223 . ( https://doi.org/10.1097/MED.0000000000000156 ) 5 Anderson RA Mitchell RT Kelsey TW Spears N Telfer EE Wallace WH . Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and