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Yuka Goto Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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Yoshie Otsuka Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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Kenji Ashida Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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Ayako Nagayama Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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Nao Hasuzawa Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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Shimpei Iwata Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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Kento Hara Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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Munehisa Tsuruta Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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Nobuhiko Wada Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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Seiichi Motomura Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
Division of Endocrinology and Metabolism, Diabetes Center, Kurume Medical Center, Kokubu-machi, Kurume-city, Fukuoka, Japan

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Yuji Tajiri Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
Division of Endocrinology and Metabolism, Diabetes Center, Kurume Medical Center, Kokubu-machi, Kurume-city, Fukuoka, Japan

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Masatoshi Nomura Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan

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to immediate improvements in insulin sensitivity by SGLT2 inhibitor administration ( 12 , 13 ). The improvements in skeletal muscle insulin sensitivity were positively correlated with the levels of improvement in daily plasma glucose fluctuations

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0082
Volume/Issue:
Volume 9: Issue 7
Open access
Chunliang Yang Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Junyi Li Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Fei Sun The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Haifeng Zhou Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Jia Yang Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Chao Yang Department of Gerontology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, China

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blood glucose fluctuation; however, it is unclear whether SGK1 is implicated and what role it plays in hyperglycemia-induced muscle wasting. Adipose tissue is deemed to be a key modulator of fuel metabolism and glucose homeostasis. Despite high salt

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0225
Volume/Issue:
Volume 9: Issue 7
Open access
Xiuzhen Zhang Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Dan Xu Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Ping Xu Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Shufen Yang Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Qingmei Zhang Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Yan Wu Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Fengyi Yuan Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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complications than constant hyperglycemia ( 12 ). For this reason, novel approaches to flattening glucose fluctuations that will reduce the risk of CVD in T1DM are in dire need. For over five decades, metformin is an oral antihyperglycemic drug that has been

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0146
Volume/Issue:
Volume 10: Issue 9
Open access
Xiaolei Hu Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Fengling Chen Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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trial from Chinese indicated that the inner daily glucose fluctuation was larger in IA-positive patients than in IA-negative ones ( 61 ) largely because of immunological insulin resistance. The IAs combined with exogenous insulin, which induced

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0309
Volume/Issue:
Volume 7: Issue 1
Open access
Po-Chung Cheng Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan

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Chia-Hung Kao Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan

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Baynes HW . Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review . EJIFCC 2019 30 179 – 194 . 25 Zhang X Xu X Jiao X Wu J Zhou S Lv X . The effects of glucose fluctuation on the severity of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0209
Volume/Issue:
Volume 10: Issue 7
Open access
Nelma Veronica Marques Neuroendocrinology Research Center, Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Luiz Eduardo Armondi Wildemberg Neuroendocrinology Research Center, Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Monica R Gadelha Neuroendocrinology Research Center, Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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levels under treatment with 20 mg were 1.06 × ULN, 120 mg/dL and 6.5%, respectively. HbA1c levels in most patients remained stable over time, and glucose fluctuations stabilised or decreased following pasireotide dose reduction. Overall, median glucose

Article Type:
Research Article
Collections:
Pituitary and Hypothalamus
DOI:
https://doi.org/10.1530/EC-23-0155
Volume/Issue:
Volume 12: Issue 10
Open access
Wei Liu Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Yunke Ma Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Xiaoling Cai Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Yu Zhu Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Mingxia Zhang Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Juan Li Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Jing Chen School of Automation, Beijing Institute of Technology, Beijing, People’s Republic of China

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Dawei Shi School of Automation, Beijing Institute of Technology, Beijing, People’s Republic of China

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Linong Ji Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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serum C-peptide level was associated with higher TIR and less blood glucose fluctuation recorded by CGM in children and adolescents with type 1 diabetes less than 2 years, but not with hypoglycemia ( 14 ). In another study conducted on adult type 1

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0244
Volume/Issue:
Volume 11: Issue 11
Open access
Jothydev Kesavadev Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India

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Pradeep Babu Sadasivan Pillai Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India

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Arun Shankar Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India

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Gopika Krishnan Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India

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Sunitha Jothydev Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India

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sitagliptin also suggest an insulin-sparing effect of DPP-4 inhibitors. Our results are similar to that reported by Yuji Tajiri and coworkers ( 31 ) where addition of sitagliptin to insulin reduced glycosylated hemoglobin and glucose fluctuation in Japanese

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0100
Volume/Issue:
Volume 6: Issue 8
Open access
Xiaomei Zhang Department of Endocrinology, Peking University International Hospital, Beijing, China

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Zhangrong Xu Diabetes Center, Characteristic Medical Center of Strategic Support Force, Beijing, China

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Xingwu Ran Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China

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Linong Ji Department of Endocrinology, Peking University International Hospital, Beijing, China
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China

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XG Xu XU Yi C Bin C Cheng QP Gong QQ Lv XF . Blood glucose fluctuation aggravates lower extremity vascular disease in type 2 diabetes . European Review for Medical and Pharmacological Sciences 2014 18 2025 – 2030 . 37 Mohammedi K

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0152
Volume/Issue:
Volume 10: Issue 9
Open access
Julia Otten Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Andreas Stomby Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Region Jönköping County, Jönköping, Sweden

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Maria Waling Department of Food, Nutrition and Culinary Science, Umeå University, Umeå, Sweden

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Elin Chorell Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Mats Ryberg Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Michael Svensson Department of Community Medicine and Rehabilitation, Section for Sports Medicine, Umeå University, Umeå Sweden

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Jens Juul Holst NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Tommy Olsson Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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. Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients . Diabetes Care 2010 33 287 – 289 . ( https://doi.org/10.2337/dc09-1343 ) 30 Wewer Albrechtsen NJ Faerch K Jensen TM Witte

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0171
Volume/Issue:
Volume 10: Issue 9
Open access