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Xiuzhen Hou
Xiuzhen Hou
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Junfeng Zhang
Junfeng Zhang
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Hehong Ma
Hehong Ma
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Ming Li
Ming Li
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Pei Wang
Pei Wang
Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China
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Introduction Gestational diabetes mellitus (GDM) is primarily resulted from insulin resistance and glucose intolerance during pregnancy, affecting 7% of pregnant women globally ( 1 , 2 ). GDM causes higher risks of diabetes, obesity and
Zhiwei Zhang
Zhiwei Zhang
Department of Obstetrics and Gynecology, Liaocheng People’s Hospital, Liaocheng, Shandong, China
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Hui Zhao
Hui Zhao
Department of Obstetrics and Gynecology, Liaocheng People’s Hospital, Liaocheng, Shandong, China
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Aixia Wang
Aixia Wang
Department of Obstetrics and Gynecology, Liaocheng People’s Hospital, Liaocheng, Shandong, China
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Introduction Gestational diabetes mellitus (GDM) manifests as various degrees of hyperglycemia during pregnancy. GDM has a high incidence rate and is by far one of the leading causes of neonatal and maternal mortality ( 1 ). The etiology of
Yusen Liu
Yusen Liu
Department of Cooperation and Communication, The First Clinical Medical College & The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, China
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Ruiwen Chi
Ruiwen Chi
Department of Cooperation and Communication, The First Clinical Medical College & The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, China
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Yujie Jiang
Yujie Jiang
School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, China
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Bicheng Chen
Bicheng Chen
Department of Cooperation and Communication, The First Clinical Medical College & The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, China
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Youli Chen
Youli Chen
Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Zengrui Chen
Zengrui Chen
Intensive Care Unit, The People’s Hospital of Yuhuan, Yuhuan, China
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Introduction Gestational diabetes mellitus (GDM), the most common medical disorder in pregnancy, is defined as glucose intolerance resulting in hyperglycemia that begins or is first diagnosed during pregnancy ( 1 ). GDM is associated with
Chenyu Jiang
Chenyu Jiang
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Mi Zhou
Mi Zhou
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Huai Bai
Huai Bai
Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Meng Chen
Meng Chen
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Chunyi Yang
Chunyi Yang
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Kaifeng Hu
Kaifeng Hu
Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Yujie Wu
Yujie Wu
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Qingqing Liu
Qingqing Liu
Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Yangyu Zhao
Yangyu Zhao
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
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Xinghui Liu
Xinghui Liu
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Ping Fan
Ping Fan
Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Introduction Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in obstetrics, characterized by carbohydrate intolerance that develops during pregnancy ( 1 ). Along with the increasing prevalence of obesity
Chenghao Piao
Chenghao Piao
Department of Radiology, The Second Affiliated Hospital of Shenyang Medical College, Shenyang City, Liaoning Province, People’s Republic of China
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Xiaojie Wang
Xiaojie Wang
Department of Human Anatomy, Shenyang Medical College, Shenyang City, Liaoning Province, People’s Republic of China
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Shiqiao Peng
Shiqiao Peng
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China
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Xinyu Guo
Xinyu Guo
Department of Obstetrics, The Second Affiliated Hospital of Shenyang Medical College, Shenyang City, Liaoning Province, People’s Republic of China
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Hui Zhao
Hui Zhao
Department of Laboratory Medicine, The Second Affiliated Hospital of Shenyang Medical College, Shenyang City, Liaoning Province, People’s Republic of China
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Li He
Li He
Department of Gastroenterology, The Second Affiliated Hospital of Shenyang Medical College, Shenyang City, Liaoning Province, People’s Republic of China
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Yan Zeng
Yan Zeng
Department of Obstetrics, The Second Affiliated Hospital of Shenyang Medical College, Shenyang City, Liaoning Province, People’s Republic of China
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Fan Zhang
Fan Zhang
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China
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Kewen Zhu
Kewen Zhu
Department of Human Anatomy, Shenyang Medical College, Shenyang City, Liaoning Province, People’s Republic of China
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Yiwei Wang
Yiwei Wang
Department of Human Anatomy, Shenyang Medical College, Shenyang City, Liaoning Province, People’s Republic of China
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Introduction Insulin sensitivity during pregnancy is reduced with the advancement of gestation. Thus, the demand for insulin is elevated to maintain the common blood sugar ( 1 ). Gestational diabetes mellitus (GDM) is characterized by glucose
Panisa Hantrakun
Panisa Hantrakun
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Rattanaporn Sekararithi
Rattanaporn Sekararithi
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Thidarat Jaiwongkam
Thidarat Jaiwongkam
Cardiac Electrophysiology Research and Training Center (CERT), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Sirinart Kumfu
Sirinart Kumfu
Cardiac Electrophysiology Research and Training Center (CERT), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Chatree Chai-adisaksopha
Chatree Chai-adisaksopha
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Nipon Chattipakorn
Nipon Chattipakorn
Cardiac Electrophysiology Research and Training Center (CERT), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Theera Tongsong
Theera Tongsong
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Phudit Jatavan
Phudit Jatavan
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Gestational diabetes mellitus (GDM), one of the most common complications in pregnancy, is defined as glucose intolerance of variable severity with onset or first recognition during pregnancy ( 1 ). GDM usually disappears shortly after birth but up to 50% will
Yao Su
Yao Su
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Li Chen
Li Chen
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Dong-Yao Zhang
Dong-Yao Zhang
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xu-Pei Gan
Xu-Pei Gan
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Yan-Nan Cao
Yan-Nan Cao
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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De-Cui Cheng
De-Cui Cheng
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Wen-Yu Liu
Wen-Yu Liu
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Fei-Fei Li
Fei-Fei Li
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xian-Ming Xu
Xian-Ming Xu
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Hong-Kun Wang
Hong-Kun Wang
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Introduction Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, and the incidence rate is increasing every year and is currently approximately 17.5% in China ( 1 ). GDM is harmful to the long- and
Vânia Benido Silva
Vânia Benido Silva
Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal
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Liliana Fonseca
Liliana Fonseca
Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal
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Maria Teresa Pereira
Maria Teresa Pereira
Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal
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Joana Vilaverde
Joana Vilaverde
Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal
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Clara Pinto
Clara Pinto
Department of Obstetrics, Centro Hospitalar Universitário do Porto, Porto, Portugal
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Fernando Pichel
Fernando Pichel
Department of Nutrition, Centro Hospitalar Universitário do Porto, Porto, Portugal
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Maria do Céu Almeida
Maria do Céu Almeida
In representation of the Diabetes and Pregnancy Study Group of the Portuguese Society of Diabetology, Lisbon, Portugal
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Jorge Dores
Jorge Dores
Department of Endocrinology, Centro Hospitalar Universitário do Porto, Porto, Portugal
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Introduction Gestational diabetes mellitus(GDM) is defined as a subtype of hyperglycemia first detected during pregnancy and accounts for 90% of all diabetes diagnoses in pregnant women ( 1 , 2 ). This represents a worrying gestational
Hathairat Rueangdetnarong
Hathairat Rueangdetnarong
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Rattanaporn Sekararithi
Rattanaporn Sekararithi
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Thidarat Jaiwongkam
Thidarat Jaiwongkam
Cardiac Electrophysiology Research and Training Center (CERT), Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Sirinart Kumfu
Sirinart Kumfu
Cardiac Electrophysiology Research and Training Center (CERT), Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Nipon Chattipakorn
Nipon Chattipakorn
Cardiac Electrophysiology Research and Training Center (CERT), Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Theera Tongsong
Theera Tongsong
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Phudit Jatavan
Phudit Jatavan
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Introduction Gestational diabetes mellitus (GDM) is the most common metabolic disease in pregnancy, characterized by abnormal blood sugar levels, leading to several maternal and neonatal adverse outcomes ( 1 ). Currently, the prevalence of GDM
Hana Vítková
Hana Vítková
H Vítková, General University Hospital in Prague, Prague, 12000, Czech Republic
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Kateřina Anderlová
Kateřina Anderlová
K Anderlová, Department of Gynaecology, Obstetrics and Neonatology, First Faculty of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Jan Krátký
Jan Krátký
J Krátký, Third Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Radovan Bílek
Radovan Bílek
R Bílek, Institute of Endocrinology, Praha, Czech Republic
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Drahomíra Springer
Drahomíra Springer
D Springer, Institute of Clinical Biochemistry and Laboratory Medicine, General University Hospital in Prague, Prague, Czech Republic
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Felix Votava
Felix Votava
F Votava, Department of Children and Adolescents, University Hospital Kralovske Vinohrady, Praha, Czech Republic
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Tomáš Brutvan
Tomáš Brutvan
T Brutvan, 3rd Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Adéla Krausová
Adéla Krausová
A Krausová, 3rd Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Kristýna Žabková
Kristýna Žabková
K Žabková, 3rd Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Eliška Potluková
Eliška Potluková
E Potluková, University Center of Internal Medicine, Cantonal Hospital Basel-Landschaft Department of Internal Medicine, Basel, Switzerland
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Jan Jiskra
Jan Jiskra
J Jiskra, 3rd Department of Medicine, General University Hospital in Prague, Prague, Czech Republic
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Introduction: Maternal urinary iodine concentration (UIC) and blood neonatal thyroid stimulating hormone (TSH) concentration reflect iodine status in pregnancy. As dietary measures in gestational diabetes mellitus (GDM) could affect iodine intake, our study aimed to investigate iodine supply in women with GDM compared to healthy pregnant women and to evaluate its relationship to thyroid function.
Methods: UIC and serum TSH, free thyroxine (FT4) and autoantibodies against thyroid peroxidase (TPOAb) were analysed in 195 women with GDM and 88 healthy pregnant women in the 2nd trimester. Subsequently, neonatal TSH concentrations measured 72 hours after delivery in a subgroup of 154 newborns (115 of mothers with GDM and 39 controls) from the national register were analysed.
Results: Optimal iodine intake was found only in nine women with GDM (4.6%) and 33 healthy pregnant women (37.5%) (P<0.001). Most pregnant women with GDM (88.7%) as compared to one half of controls (50%) had iodine deficiency (P<0.001). Also, hypothyroxinaemia was more prevalent in GDM compared to controls (12.3% vs 3.4%, P = 0.032). Consistently, neonatal TSH >5.0 mIU/L indicating iodine deficiency was found in 6 (5.2%) newborns of women with GDM as compared to none in controls. In the multiple logistic and linear regression models in women with GDM, hypothyroxinaemia was associated with preterm births, and a negative association of serum FT4 and HbA1c was found.
Conclusion: Iodine deficiency in pregnancy was more prevalent among women with GDM compared to healthy pregnant controls. Hypothyroxinaemia was associated with preterm births in women with GDM.
