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Ayako Sato Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Katsuya Matsuda Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Takahiro Motoyama Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Zhanna Mussazhanova Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Al-Farabi Kazakh National University, Almaty City, Republic of Kazakhstan

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Ryota Otsubo Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Hisayoshi Kondo Biostatics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Yuko Akazawa Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Miyoko Higuchi Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Ayana Suzuki Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Mitsuyoshi Hirokawa Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Akira Miyauchi Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Takeshi Nagayasu Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Masahiro Nakashima Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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VG Halazonetis TD Genomic instability-an evolving hallmark of cancer . Nature Reviews: Molecular Cell Biology 2010 11 220 – 228 . ( https://doi.org/10.1038/nrm2858 ) 7 Nakashima M Suzuki K Meirmanov S Naruke Y Matsuu-Matsuyama M

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0630
Volume/Issue:
Volume 10: Issue 3
Open access
Pamela Stratton Office of the Clinical Director, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA

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Neelam Giri Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Sonia Bhala Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Martha M Sklavos Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

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Blanche P Alter Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Sharon A Savage Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Ligia A Pinto Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

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developmental and therapeutic perspective on a multifaceted disease . Seminars in Cell and Developmental Biology 2021 113 113 – 131 . ( https://doi.org/10.1016/j.semcdb.2020.11.010 ) 38 Keefe DL . Telomeres and genomic instability during early development

Article Type:
Research Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-23-0510
Volume/Issue:
Volume 13: Issue 9
Open access
Dario de Biase Department of Pharmacy and Biotechnology (Dipartimento di Farmacia e Biotecnologie) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy

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Federica Torricelli Laboratory of Translational Research, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy

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Moira Ragazzi Pathology Unit, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy

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Benedetta Donati Laboratory of Translational Research, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy

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Elisabetta Kuhn Pathology Unit, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy

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Michela Visani Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy

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Giorgia Acquaviva Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy

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Annalisa Pession Department of Pharmacy and Biotechnology (Dipartimento di Farmacia e Biotecnologie) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy

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Giovanni Tallini Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy

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Simonetta Piana Pathology Unit, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy

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Alessia Ciarrocchi Laboratory of Translational Research, Azienda Unità Sanitaria Locale AUSL-IRCCS, Reggio Emilia, Italy

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mutations in the three most frequently altered genes ( TERT , BRAF and TP53 ) in DM-PTC (C) and ATC (D). Mutational load negatively affects survival of thyroid cancer patient It is established that high degree of genomic instability

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0386
Volume/Issue:
Volume 7: Issue 12
Open access
Simon Schimmack European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Yongchao Yang European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China

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Klaus Felix European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Markus Herbst European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Yixiong Li Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China

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Miriam Schenk European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Frank Bergmann Institute of Pathology, Heidelberg University, Heidelberg, Germany

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Thilo Hackert European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Oliver Strobel European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany

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genomic instability and are important tumor progression-promoting signals ( 23 , 24 ). Chronic inflammation is able to stimulate endocrine cells leading to their hyperplasia and neoplastic transformation ( 25 ) such as IL-1 was able to direct cancer

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0132
Volume/Issue:
Volume 8: Issue 7
Open access
Ishita Gupta Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman

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Allal Ouhtit Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar

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Adil Al-Ajmi Department of Surgery, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman

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Syed Gauhar A Rizvi Department of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman

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Hamad Al-Riyami Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman

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Marwa Al-Riyami Department of Pathology, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman

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Yahya Tamimi Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman

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in this study, indicates BRIP1 to be an oncogene in sporadic cases. Overexpression of certain tumor suppressors including BRIP1 , can lead to genomic instability in cellular processing involved in genome integrity maintenance and contribute to the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0173
Volume/Issue:
Volume 7: Issue 1
Open access
Hui Li Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, P. R. China.

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Peng Wu Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, P. R. China.

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intricate mechanisms by which epigenetic alterations can drive cancer progression ( 32 ). Furthermore, global hypomethylation, observed in various thyroid cancer studies, contributes to genomic instability, a hallmark of many cancers ( 33 , 34 ). This

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-24-0087
Volume/Issue:
Volume 13: Issue 9
Open access