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Ali Abbasi

was updated via a systematic literature search to identify Mendelian randomization studies. Next, summary data from the two largest genome-wide association studies (GWAS) for T2D or glycaemic traits (10, 11) were used to examine the effect estimates

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Iben Katinka Greiber, Casper P Hagen, Alexander Siegfried Busch, Mikkel Grunnet Mieritz, Lise Aksglæde, Katharina Main, Kristian Almstrup and Anders Juul

and AMHR2 may modify age at natural menopause. PLoS ONE 2013 8 8 – 11 . 26 Perry JRB McMahon G Day FR Ring SM Nelson SM Lawlor DA. Genome-wide association study identifies common and low-frequency variants at the AMH gene locus that

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Dmitry M Davydov and Malik K Nurbekov

studies showed that HbA 1c is not affected by plasma glucose instability and has a close relationship with mean or average plasma glucose (MPG) ( 3 ). However, correlations between HbA 1c and FPG are low. Twin, family, and genome-wide association studies

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R A M Quax, J A M van Laar, R van Heerebeek, K Greiner, E Ben-Chetrit, M Stanford, G R Wallace, F Fortune, M Ghabra, M Soylu, J M W Hazes, S W J Lamberts, J H Kappen, P M van Hagen, J W Koper and R A Feelders

polymorphisms in three independent cohorts. None of the GR polymorphisms was associated with susceptibility to BD, consistent with two recent genome-wide association studies from Turkey and Japan (5, 28) . However, we found significant differences in the

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Renata C Scalco, Ericka B Trarbach, Edoarda V A Albuquerque, Thais K Homma, Thais H Inoue-Lima, Mirian Y Nishi, Berenice B Mendonca and Alexander A L Jorge

) and karyotype ( 7 ). Nevertheless, there are controversies among studies and none of these factors can thoroughly explain the interindividual variation. Genome-wide association studies (GWAS) showed that polymorphisms in estrogen receptor 1 gene

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Piera Rizzolo, Valentina Silvestri, Virginia Valentini, Veronica Zelli, Agostino Bucalo, Ines Zanna, Simonetta Bianchi, Maria Grazia Tibiletti, Antonio Russo, Liliana Varesco, Gianluca Tedaldi, Bernardo Bonanni, Jacopo Azzollini, Siranoush Manoukian, Anna Coppa, Giuseppe Giannini, Laura Cortesi, Alessandra Viel, Marco Montagna, Paolo Peterlongo, Paolo Radice, Domenico Palli and Laura Ottini

1 rs1056836 and rs1800440 may contribute to MBC risk. Notably, loci for these two candidate genes have never emerged in any of the Genome Wide Association Studies (GWAS) on both female and male BCs as reported in the GWAS Catalog ( 33 ), thus

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Anastasia K Armeni, Konstantinos Assimakopoulos, Dimitra Marioli, Vassiliki Koika, Euthychia Michaelidou, Niki Mourtzi, Gregoris Iconomou and Neoklis A Georgopoulos

vulvar vestibulitis syndrome scores, a broader phenotype for sexual pain symptoms ( 59 ). On a genome-wide association study (GWAS) on 2.5 million single-nucleotide polymorphisms, three polymorphic sites (rs13202860, rs1876525 and rs13209281) around 500

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Katherine A Bolton, Kelly A Avery-Kiejda, Elizabeth G Holliday, John Attia, Nikola A Bowden and Rodney J Scott

be analysed on a large scale, with recent emphasis being on genome-wide association studies, which are unable to detect polymorphisms produced by variable TRs ( 49 ). High-throughput techniques, such as next-generation sequencing, are not readily

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Yao Chen and Shu-ying Fang

), where it participates in energy metabolism ( 37 ). A genome-wide association study in 2007 associated the FTO gene with body mass index (BMI) and obesity ( 38 ). Obesity is a common characteristic of PCOS; more than 50% of PCOS patients are overweight

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Ozlem Atan Sahin, Damla Goksen, Aysel Ozpinar, Muhittin Serdar and Huseyin Onay

vitamin D insufficiency: a genome-wide association study . Lancet 2010 376 180 – 188 . ( doi:10.1016/S0140-6736(10)60588-0 ) 38 Ahn J Yu K Stolzenberg-Solomon R Simon KC McCullough ML Gallicchio L Jacobs EJ Ascherio