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Sandra Pereira Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Jessy Moore Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada

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Jia-Xu Li Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada

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Wen Qin Yu Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Husam Ghanim Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA

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Filip Vlavcheski Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada

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Yemisi Deborah Joseph Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Paresh Dandona Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA

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Allen Volchuk Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

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Carolyn L Cummins Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada

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Evangelia Tsiani Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada

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Adria Giacca Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada

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Introduction Obesity is characterized by elevated circulating free fatty acids (FFAs) that cause insulin resistance in the liver and periphery ( 1 , 2 ). FFAs induce endoplasmic reticulum (ER) stress, which occurs when misfolded or unfolded

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0248
Volume/Issue:
Volume 10: Issue 8
Open access
Chenmin Wei Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Department of Endocrinology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Zichen Zhang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Qi Fu Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Yunqiang He Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Tao Yang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Min Sun Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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. Journal of Proteome Research 2018 17 3824 – 3836 . ( https://doi.org/10.1021/acs.jproteome.8b00239 ) 20 Salgin B Ong KK Thankamony A Emmett P Wareham NJ Dunger DB . Higher fasting plasma free fatty acid levels are associated with lower

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Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0221
Volume/Issue:
Volume 12: Issue 1
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Arpna Sharma Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Vijay Simha Baddela Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Frank Becker Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Dirk Dannenberger Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Torsten Viergutz Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Jens Vanselow Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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combination on steroidogenesis, cell proliferation and apoptosis in an in vitro bovine GC culture model might contribute to our understanding of the collective effects of elevated free fatty acid concentrations during NEB on bovine reproduction. Thus, in the

Article Type:
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DOI:
https://doi.org/10.1530/EC-19-0011
Volume/Issue:
Volume 8: Issue 5
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Julie Smith Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark

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Jan Fahrenkrug Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark

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Henrik L Jørgensen Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark

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Christina Christoffersen Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark

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Jens P Goetze Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark

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acids, glycerol, and insulin in serum Enzymatic kits were used to determine serum concentrations of triglycerides (TGs) and glycerol (GPO-TRINDER; Sigma) and free fatty acids (FFA) (WAKO NEFA C Kit; TriChem Aps, Frederikssund, Denmark). Five microlitre

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Research Article
DOI:
https://doi.org/10.1530/EC-15-0074
Volume/Issue:
Volume 4: Issue 4
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Cleofas Marcial-Medina Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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Alejandra Ordoñez-Moreno Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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Christian Gonzalez-Reyes Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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Pedro Cortes-Reynosa Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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Eduardo Perez Salazar Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico

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cancer cells ( 5 , 6 , 8 , 9 , 10 ). Free fatty acid receptor 1 (FFAR1) and FFAR4 are G protein-coupled receptors activated by medium- to long-chain fatty acids, such as OA; but they are not activated by short chain FFAs ( 11 , 12 ). FFAR1 is

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0543
Volume/Issue:
Volume 8: Issue 3
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J Chycki Department of Sports Training, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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A Zajac Department of Sports Training, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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M Michalczyk Department of Sports Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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A Maszczyk Department of Methodology and Statistics, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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J Langfort Department of Sports Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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, glucose (G) – t0, t1, t2, t3, free fatty acids (FFA) – t0, t1, t2, t3, and glycerol (GC) – t0, t1, t2, t3. All hormone concentrations as well as FFA and glycerol concentrations were evaluated in blood serum. On the other hand, glucose concentration was

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Research Article
DOI:
https://doi.org/10.1530/EC-19-0216
Volume/Issue:
Volume 8: Issue 7
Open access
Katrine M Lauritsen Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark

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Jens Hohwü Voigt Steno Diabetes Center Aarhus, Aarhus, Denmark

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Steen Bønløkke Pedersen Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Troels K Hansen Steno Diabetes Center Aarhus, Aarhus, Denmark

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Niels Møller Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Niels Jessen Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Biomedicine, Aarhus University, Aarhus, Denmark

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Lars C Gormsen Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark

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Esben Søndergaard Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark

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affected by SGLT2 inhibition. SGLT2 inhibition reduces insulin concentration, a potent inhibitor of lipolysis ( 8 ), and therefore causes increased lipolysis. As a counterbalancing mechanism, increased free fatty acids (FFA) levels result in increased

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Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-21-0558
Volume/Issue:
Volume 11: Issue 4
Open access
Nikolaj Rittig Department of Internal Medicine and Endocrinology (MEA) and Medical Research Laboratory, Aarhus University Hospital, Aarhus C, Denmark

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Mads Svart Department of Internal Medicine and Endocrinology (MEA) and Medical Research Laboratory, Aarhus University Hospital, Aarhus C, Denmark

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Niels Jessen Research Laboratory for Biochemical Pathology, Institute for Clinical Medicine, Aarhus University Hospital, Aarhus C, Denmark

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Niels Møller Department of Internal Medicine and Endocrinology (MEA) and Medical Research Laboratory, Aarhus University Hospital, Aarhus C, Denmark

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Holger J Møller Department of Clinical Biochemistry Aarhus University Hospital, Aarhus C, Denmark

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Henning Grønbæk Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus C, Denmark

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increased circulating free fatty acid (FFA) levels ( 7 , 8 , 9 ). Administration of LPS to healthy human volunteers is a well-established model simulating the initial steps of sepsis ( 10 ). The model excels itself by producing a homogeneous and uniform

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https://doi.org/10.1530/EC-17-0296
Volume/Issue:
Volume 7: Issue 1
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Jeyanthini Risikesan Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Birgitte Nellemann Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

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Britt Christensen Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Jens Otto Lunde Jørgensen Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Søren Nielsen Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

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energy expenditure (REE) ( 22 ) and plasma free fatty acids (FFA) concentrations albeit with non-significant changes in lipolysis (palmitate turnover) in healthy men ( 22 ). In addition, Caillaud et al. ( 4 ) found no effect on resting lipid oxidation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0305
Volume/Issue:
Volume 9: Issue 12
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Shanlee M Davis Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA

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Rhianna Urban Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

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Angelo D’Alessandro Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Julie A Reisz Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Christine L Chan Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Megan Kelsey Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Susan Howell Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA

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Nicole Tartaglia Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA

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Philip Zeitler Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
eXtraOrdinarY Kids Clinic, Children's Hospital Colorado, Aurora, Colorado, USA

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Peter Baker II Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA

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Research 2010 9 4368 – 4375 . ( https://doi.org/10.1021/pr100101p ) 25 Kao CC Yang ZY Cheng YW & Chen WL . Examining the association between serum free fatty acids and blood levels of testosterone . Journal of Human Nutrition and Dietetics

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Reproduction
DOI:
https://doi.org/10.1530/EC-22-0523
Volume/Issue:
Volume 12: Issue 5
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