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J Chycki, A Zajac, M Michalczyk, A Maszczyk and J Langfort


The present study verified the effect of moderate-to-high-intensity aerobic exercise on the endocrine response profile and adipose tissue in young healthy men with different phenotype characteristics.


Eighteen men were divided into three experimental groups with defined body components and specific physical fitness: Endurance phenotype – EP (n = 6; low body mass; low fat content; aerobic endurance trained), Athletic phenotype – AP (n = 6; high body mass; low fat content, resistance trained), Obesity phenotype – OP (n = 6; high body mass; high fat content, untrained).


The participants performed an progressive exercise protocol on a treadmill (30% VO2max, 50% VO2max, 70% VO2max), separated by 45 s of passive rest for blood collection.


Plasma glucose oxidation increased in relation to exercise intensity, but to a greater extent in the AP group. The free fatty acids’ plasma level decreased with a rise in exercise intensity, but with different kinetics in particular phenotypes. Plasma growth hormone increased after the cessation of exercise and was significantly higher in all groups 45 min into recovery compared to resting values. Plasma insulin decreased during exercise in all groups, but in the OP, the decrease was blunted.


The results indicate that the rate of lipolysis, hormonal and metabolic response to aerobic exercise depends on the individuals’ phenotype. Thus, exercise type, duration and intensity have to be strictly individualized in relation to phenotype in order to reach optimal metabolic benefits.

Open access

Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller and Henning Grønbæk

RA . Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance . Journal of Clinical Investigation 1989 84 205 – 213 . ( ) 10.1172/JCI

Open access

Renea A Taylor, Jennifer Lo, Natasha Ascui and Matthew J Watt

series: Patient-Oriented Research. Free fatty acid metabolism in human obesity . Journal of Lipid Research 2006 47 1643 – 1650 . ( doi:10.1194/jlr.R600011-JLR200 ). 77 Boren J Taskinen MR Olofsson SO Levin M . Ectopic lipid storage and

Open access

Leanne Hodson and Fredrik Karpe

. Insulin regulation of regional free fatty acid metabolism . Diabetes 1999 10 – 14. ( ) 9892216

Open access

Michaela Keuper

Nurjhan N . Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification . American Journal of Physiology 1992 263 E1063 – E1069 . ( ) 10.1152/ajpendo.2006