Abdul K Siraj
Abdul K Siraj
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Rong Bu
Rong Bu
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Maham Arshad
Maham Arshad
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Kaleem Iqbal
Kaleem Iqbal
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Sandeep Kumar Parvathareddy
Sandeep Kumar Parvathareddy
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Tariq Masoodi
Tariq Masoodi
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Laila Omar Ghazwani
Laila Omar Ghazwani
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Saif S Al-Sobhi
Saif S Al-Sobhi
Department of Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Fouad Al-Dayel
Fouad Al-Dayel
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Khawla S Al-Kuraya
Khawla S Al-Kuraya
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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variant of PTC ( P = 0.0006), distant metastasis ( P = 0.0033) and stage IV tumours ( P = 0.0081) ( Table 4 ). The POLD1 mutant case showed over-expression of POLD1 protein. Both POLE and POLD1 protein expression were not associated with disease
Klaudia Zajkowska
Klaudia Zajkowska
Endocrinology, Holycross Cancer Centre, Kielce, Poland
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Janusz Kopczyński
Janusz Kopczyński
Surgical Pathology, Holycross Cancer Centre, Kielce, Poland
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Stanisław Góźdź
Stanisław Góźdź
Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland
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Aldona Kowalska
Aldona Kowalska
Endocrinology, Holycross Cancer Centre, Kielce, Poland
Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland
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Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland
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Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a borderline thyroid tumour formerly known as noninvasive encapsulated follicular variant of papillary thyroid carcinoma. The prevalence of NIFTP is estimated at 4.4–9.1% of all papillary thyroid carcinomas worldwide; however, the rate of occurrence of NIFTP is eight times lower in Asian countries than in Western Europe and America. At the molecular level, NIFTP is characterised by the lack of BRAF V600E and BRAF V600E-like mutations or other high-risk mutations (TERT, TP53) and a high rate of RAS mutations, which is similar to other follicular-pattern thyroid tumours. The diagnosis of NIFTP can only be made after histological examination of the entire tumour removed during surgery and is based on strictly defined inclusion and exclusion criteria. Although the diagnosis is postoperative, the combination of certain findings of preoperative tests including ultrasonography, cytology, and molecular testing may raise suspicion of NIFTP. These tumours can be effectively treated by lobectomy, although total thyroidectomy remains an option for some patients. Radioactive iodine and thyroid stimulating hormone suppression therapy are not required. NIFTP has an extremely good prognosis, even when treated conservatively with lobectomy alone. Nevertheless, it cannot be considered as a benign lesion. The risk of adverse outcomes, including lymph node and distant metastases, is low but not negligible.
Barbora Pekova
Barbora Pekova
Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
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Sarka Dvorakova
Sarka Dvorakova
Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
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Vlasta Sykorova
Vlasta Sykorova
Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
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Gabriela Vacinova
Gabriela Vacinova
Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
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Eliska Vaclavikova
Eliska Vaclavikova
Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
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Jitka Moravcova
Jitka Moravcova
Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
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Rami Katra
Rami Katra
Department of Ear, Nose and Throat, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic
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Petr Vlcek
Petr Vlcek
Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic
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Pavla Sykorova
Pavla Sykorova
Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic
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Daniela Kodetova
Daniela Kodetova
Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic
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Josef Vcelak
Josef Vcelak
Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
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Bela Bendlova
Bela Bendlova
Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
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in many different types of cancer, including PTC. Several variants have been revealed in the conserved part of the IDH1 gene with an association with follicular variant of PTC ( 14 ). In the EZH1 gene a hotspot Q571R mutation was detected that
Ana P Estrada-Flórez
Ana P Estrada-Flórez
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Caldas, Colombia
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Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Caldas, Colombia
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Mabel E Bohórquez
Mabel E Bohórquez
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
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Alejandro Vélez
Alejandro Vélez
Dinamica IPS, Medellín, Antioquia, Colombia
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
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Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
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Carlos S Duque
Carlos S Duque
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
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Jorge H Donado
Jorge H Donado
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
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Gilbert Mateus
Gilbert Mateus
Hospital Federico Lleras Acosta, Ibagué, Tolima, Colombia
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Cesar Panqueba-Tarazona
Cesar Panqueba-Tarazona
Universidad Surcolombiana, Neiva, Huila, Colombia
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Guadalupe Polanco-Echeverry
Guadalupe Polanco-Echeverry
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
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Ruta Sahasrabudhe
Ruta Sahasrabudhe
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
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Magdalena Echeverry
Magdalena Echeverry
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
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Luis G Carvajal-Carmona
Luis G Carvajal-Carmona
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Dinamica IPS, Medellín, Antioquia, Colombia
University of California Davis Comprehensive Cancer Center, Sacramento, California, USA
Fundación de Genética y Genómica, Medellín, Antioquia, Colombia
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Dinamica IPS, Medellín, Antioquia, Colombia
University of California Davis Comprehensive Cancer Center, Sacramento, California, USA
Fundación de Genética y Genómica, Medellín, Antioquia, Colombia
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. b Vital status was unknown in four patients. CVPTC, classical variant of PTC (papillary thyroid carcinoma); FVPTC, follicular variant of PTC; LNM, lymph node metastasis; ETT, extra-thyroid extension. Comparisons of clinical data in
Jiaxin Luo
Jiaxin Luo
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Weili Yin
Weili Yin
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Qiuxia Lin
Qiuxia Lin
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China
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Juqing Wu
Juqing Wu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Pan Chen
Pan Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yuanna Ling
Yuanna Ling
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Jing Wang
Jing Wang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Zhen Li
Zhen Li
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Liqin Pan
Liqin Pan
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yanying Chen
Yanying Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Wei Ouyang
Wei Ouyang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Huijuan Feng
Huijuan Feng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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(histotypes: classic papillary thyroid carcinoma (PTC) and follicular variant of PTC, respectively) underwent resection of bone lesions before RAIT, so it was impossible to analyze the LPFS of bone lesions after RAIT in these cases. Therefore, 89 patients were
Sara Ahmadi
Sara Ahmadi
Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
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Alexandra Coleman
Alexandra Coleman
Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
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Nathalie Silva de Morais
Nathalie Silva de Morais
Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
Endocrinology Service, Instituto Nacional de Câncer, Rio de Janeiro, Brazil
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Endocrinology Service, Instituto Nacional de Câncer, Rio de Janeiro, Brazil
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Iñigo Landa
Iñigo Landa
Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
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Theodora Pappa
Theodora Pappa
Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
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Alex Kang
Alex Kang
Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
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Matthew I Kim
Matthew I Kim
Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
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Ellen Marqusee
Ellen Marqusee
Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
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Erik K Alexander
Erik K Alexander
Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
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Warthin-like, oncocytic variant PTC and PTC with high-grade features. b Solid variant, sclerosing variant, columnar variant. FVPTC, follicular variant of PTC; PTC, papillary thyroid carcinoma; RAI, radioactive iodine treatment; TCVPTC, tall
Catarina Tavares
Catarina Tavares
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Maria João Coelho
Maria João Coelho
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal
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Catarina Eloy
Catarina Eloy
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Miguel Melo
Miguel Melo
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, University and Hospital Center of Coimbra, Coimbra, Portugal
Medical Faculty, University of Coimbra, Coimbra, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, University and Hospital Center of Coimbra, Coimbra, Portugal
Medical Faculty, University of Coimbra, Coimbra, Portugal
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Adriana Gaspar da Rocha
Adriana Gaspar da Rocha
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Public Health Unit, ACeS Baixo Mondego, Coimbra, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Public Health Unit, ACeS Baixo Mondego, Coimbra, Portugal
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Ana Pestana
Ana Pestana
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Rui Batista
Rui Batista
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Luciana Bueno Ferreira
Luciana Bueno Ferreira
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Elisabete Rios
Elisabete Rios
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Hospital de S. João, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Hospital de S. João, Porto, Portugal
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Samia Selmi-Ruby
Samia Selmi-Ruby
Inserm UMR-S1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Bruno Cavadas
Bruno Cavadas
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal
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Luísa Pereira
Luísa Pereira
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
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Manuel Sobrinho Simões
Manuel Sobrinho Simões
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Hospital de S. João, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Hospital de S. João, Porto, Portugal
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Paula Soares
Paula Soares
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
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) were obtained from the contralateral lobe of the surgical specimens. Carcinomas series was composed by 193 PTCs (123 cases of classical PTC (cPTC), 47 cases of follicular variant of PTC (fvPTC) and 23 cases of other PTC variants), 23 follicular thyroid
Sara Ahmadi
Sara Ahmadi
Division of Endocrinology, Thyroid Section, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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Iñigo Landa
Iñigo Landa
Division of Endocrinology, Thyroid Section, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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tumors, including 10–20% of PTC, particularly in the follicular variant of PTC (fvPTC), 40–50% of FTC, and 20–40% of PDTC and ATC ( 14 ). The lower allelic frequency of RAS mutations in follicular adenomas than carcinomas might explain why they are
