Search for other papers by Liza Haqq in
Google Scholar
PubMed
Search for other papers by James McFarlane in
Google Scholar
PubMed
Search for other papers by Gudrun Dieberg in
Google Scholar
PubMed
Search for other papers by Neil Smart in
Google Scholar
PubMed
Polycystic ovarian syndrome (PCOS) affects 18–22% of women at reproductive age. We conducted a systematic review and meta-analysis evaluating the expected benefits of lifestyle (exercise plus diet) interventions on the reproductive endocrine profile in women with PCOS. Potential studies were identified by systematically searching PubMed, CINAHL and the Cochrane Controlled Trials Registry (1966–April 30, 2013) systematically using key concepts of PCOS. Significant improvements were seen in women receiving lifestyle intervention vs usual care in follicle-stimulating hormone (FSH) levels, mean difference (MD) 0.39 IU/l (95% CI 0.09 to 0.70, P=0.01), sex hormone-binding globulin (SHBG) levels, MD 2.37 nmol/l (95% CI 1.27 to 3.47, P<0.0001), total testosterone levels, MD −0.13 nmol/l (95% CI −0.22 to −0.03, P=0.008), androstenedione levels, MD −0.09 ng/dl (95% CI −0.15 to −0.03, P=0.005), free androgen index (FAI) levels, MD −1.64 (95% CI −2.94 to −0.35, P=0.01) and Ferriman–Gallwey (FG) score, MD −1.01 (95% CI −1.54 to −0.48, P=0.0002). Significant improvements were also observed in women who received exercise-alone intervention vs usual care in FSH levels, MD 0.42 IU/l (95% CI 0.11 to 0.73, P=0.009), SHBG levels, MD 3.42 nmol/l (95% CI 0.11 to 6.73, P=0.04), total testosterone levels, MD −0.16 nmol/l (95% CI −0.29 to −0.04, P=0.01), androstenedione levels, MD −0.09 ng/dl (95% CI −0.16 to −0.03, P=0.004) and FG score, MD −1.13 (95% CI −1.88 to −0.38, P=0.003). Our analyses suggest that lifestyle (diet and exercise) intervention improves levels of FSH, SHBG, total testosterone, androstenedione and FAI, and FG score in women with PCOS.
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Search for other papers by Signe Kirkegaard in
Google Scholar
PubMed
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Search for other papers by Nanna Maria Uldall Torp in
Google Scholar
PubMed
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
Search for other papers by Stig Andersen in
Google Scholar
PubMed
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Search for other papers by Stine Linding Andersen in
Google Scholar
PubMed
). Thus, the role of thyroid hormones in female reproduction is biologically plausible and a focus of clinical care. A link between thyroid disease and infertility as well as early pregnancy complications has been established; however, uncertainties
Search for other papers by M Boering in
Google Scholar
PubMed
Isala, Department of Internal Medicine, Zwolle, The Netherlands
Search for other papers by P R van Dijk in
Google Scholar
PubMed
Langerhans Medical Research group, Zwolle, The Netherlands
Search for other papers by S J J Logtenberg in
Google Scholar
PubMed
Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Search for other papers by K H Groenier in
Google Scholar
PubMed
Search for other papers by B H R Wolffenbuttel in
Google Scholar
PubMed
Search for other papers by R O B Gans in
Google Scholar
PubMed
Langerhans Medical Research group, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Search for other papers by N Kleefstra in
Google Scholar
PubMed
Isala, Department of Internal Medicine, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Search for other papers by H J G Bilo in
Google Scholar
PubMed
2008 93 1796 – 1803 . ( doi:10.1210/jc.2007-2358 ) 35 Codner E Merino PM Tena-Sempere M. Female reproduction and type 1 diabetes: from mechanisms to clinical findings . Human Reproduction Update 2012 18 568 – 585 . ( doi:10
Search for other papers by Angela Köninger in
Google Scholar
PubMed
Search for other papers by Philippos Edimiris in
Google Scholar
PubMed
Search for other papers by Laura Koch in
Google Scholar
PubMed
Search for other papers by Antje Enekwe in
Google Scholar
PubMed
Search for other papers by Claudia Lamina in
Google Scholar
PubMed
Search for other papers by Sabine Kasimir-Bauer in
Google Scholar
PubMed
Search for other papers by Rainer Kimmig in
Google Scholar
PubMed
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
Search for other papers by Hans Dieplinger in
Google Scholar
PubMed
stress on female reproduction: a review . Reproductive Biology and Endocrinology 2012 10 49 . ( doi:10.1186/1477-7827-10-49 ). 24 Blair SA Kyaw-Tun T Young IS Phelan NA Gibney J McEneny J . Oxidative stress and inflammation in lean and
Search for other papers by Mírian Romitti in
Google Scholar
PubMed
Search for other papers by Vitor C Fabris in
Google Scholar
PubMed
Search for other papers by Patricia K Ziegelmann in
Google Scholar
PubMed
Search for other papers by Ana Luiza Maia in
Google Scholar
PubMed
Search for other papers by Poli Mara Spritzer in
Google Scholar
PubMed
England Journal of Medicine 2001 345 260 – 265 . ( https://doi.org/10.1056/NEJM200107263450406 ) 10.1056/NEJM200107263450406 29 Poppe K Velkeniers B Glinoer D. Thyroid disease and female reproduction . Clinical Endocrinology 2007 66 309
Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
Search for other papers by Kerry V Fanson in
Google Scholar
PubMed
Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
Search for other papers by Tamara Keeley in
Google Scholar
PubMed
Search for other papers by Benjamin G Fanson in
Google Scholar
PubMed
-hydroxysteroid dehydrogenase (11βHSD) . Molecular and Cellular Endocrinology 1994 100 55 – 63 . ( doi:10.1016/0303-7207(94)90279-8 ). 4 Brann D Mahesh V . Role of corticosteroids in female reproduction . FASEB Journal 1991 5 2691 – 2698 . ( doi:10.1096/fj
Search for other papers by Rosalie Cabry in
Google Scholar
PubMed
Search for other papers by Philippe Merviel in
Google Scholar
PubMed
Search for other papers by Aicha Madkour in
Google Scholar
PubMed
Search for other papers by Elodie Lefranc in
Google Scholar
PubMed
Search for other papers by Florence Scheffler in
Google Scholar
PubMed
Search for other papers by Rachel Desailloud in
Google Scholar
PubMed
Search for other papers by Véronique Bach in
Google Scholar
PubMed
Search for other papers by Moncef Benkhalifa in
Google Scholar
PubMed
porcine oocytes and possible mechanisms of action . PLoS ONE 2017 22 e0179861 . ( https://doi.org/10.1371/journal.pone.0179861 ) 53 Zhou YJ Huang HR Zhou J Wang LQ . beta-Cypermethrin exposure affects female reproduction by enhancing
Search for other papers by Stavroula Stavrou in
Google Scholar
PubMed
Search for other papers by Michael Gratz in
Google Scholar
PubMed
Search for other papers by Eileen Tremmel in
Google Scholar
PubMed
Search for other papers by Christina Kuhn in
Google Scholar
PubMed
Search for other papers by Simone Hofmann in
Google Scholar
PubMed
Search for other papers by Helene Heidegger in
Google Scholar
PubMed
Search for other papers by Mina Peryanova in
Google Scholar
PubMed
Search for other papers by Kerstin Hermelink in
Google Scholar
PubMed
Search for other papers by Stefan Hutter in
Google Scholar
PubMed
Search for other papers by Bettina Toth in
Google Scholar
PubMed
Search for other papers by Doris Mayr in
Google Scholar
PubMed
Search for other papers by Sven Mahner in
Google Scholar
PubMed
Search for other papers by Udo Jeschke in
Google Scholar
PubMed
Search for other papers by Aurelia Vattai in
Google Scholar
PubMed
. Nuclear hormone receptors and female reproduction. Current Molecular Medicine 2013 13 1066 – 1078 . ( https://doi.org/10.2174/1566524011313070002 ) 5 Ziegelmuller B Vattai A Kost B Kuhn C Hofmann S Bayer B Toth B Jeschke U Ditsch N . Expression
Search for other papers by Lian Hollander-Cohen in
Google Scholar
PubMed
Search for other papers by Benjamin Böhm in
Google Scholar
PubMed
Search for other papers by Krist Hausken in
Google Scholar
PubMed
Search for other papers by Berta Levavi-Sivan in
Google Scholar
PubMed
female reproduction . Fish Physiology and Biochemistry 2014 1849 – 1861 . ( https://doi.org/10.1007/s10695-014-9973-0 ) 36 Moyle WR Campbell RK Myers RV Bernard MP Han Y Wang X . Co-evolution of ligand-receptor pairs . Nature 1994
Search for other papers by Yao Ye in
Google Scholar
PubMed
Search for other papers by Aurelia Vattai in
Google Scholar
PubMed
Search for other papers by Nina Ditsch in
Google Scholar
PubMed
Search for other papers by Christina Kuhn in
Google Scholar
PubMed
Search for other papers by Martina Rahmeh in
Google Scholar
PubMed
Search for other papers by Sven Mahner in
Google Scholar
PubMed
Search for other papers by Myriam Ripphahn in
Google Scholar
PubMed
Search for other papers by Roland Immler in
Google Scholar
PubMed
Search for other papers by Markus Sperandio in
Google Scholar
PubMed
Search for other papers by Udo Jeschke in
Google Scholar
PubMed
Search for other papers by Viktoria von Schönfeldt in
Google Scholar
PubMed
Toth B Markert UR Jeschke U. Nuclear hormone receptors and female reproduction . Current Molecular Medicine 2013 13 1066 – 1078 . ( https://doi.org/10.2174/1566524011313070002 ) 23116264 10.2174/1566524011313070002 21 Pestka A Toth B Kuhn C
