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currently believed that the mechanism of action of serum CLU in metabolic diseases may be through several pathways. First, CLU may be an anorexia-inducing factor, and the key factor through which the hypothalamus controls energy metabolism. Animal studies
Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, China
Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, China
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Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, China
Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, China
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respectively located in the ER and outer membrane, and their downregulation could affect calcium ion transfer and energy metabolism between mitochondria and the ER ( 20 , 21 , 22 ). Drp1 is a protein involved in mitochondrial fission and its downregulation
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://doi.org/10.1016/j.neulet.2012.10.010 ) 35 Huang Y Liu Q Huang G Wen J & Chen G . Hypothalamic kisspeptin neurons regulates energy metabolism and reproduction under chronic stress . Frontiers in Endocrinology (Lausanne) 2022 13 844397 . ( https