Sarah J Delforce
Sarah J Delforce
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Eugenie R Lumbers
Eugenie R Lumbers
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Celine Corbisier de Meaultsart
Celine Corbisier de Meaultsart
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Yu Wang
Yu Wang
Oregon Health and Science University, Portland, Oregon, USA
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Anthony Proietto
Anthony Proietto
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Geoffrey Otton
Geoffrey Otton
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Jim Scurry
Jim Scurry
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Nicole M Verrills
Nicole M Verrills
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Kirsty G Pringle
Kirsty G Pringle
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Introduction Endometrial cancer is the most common gynaecological malignancy, and the sixth most common cancer in women worldwide, with 320,000 new cases and 76,000 deaths in 2012 ( 1 ). The incidence of endometrial cancer is increasing due to
Katherine A Bolton
Katherine A Bolton
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Kelly A Avery-Kiejda
Kelly A Avery-Kiejda
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Elizabeth G Holliday
Elizabeth G Holliday
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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John Attia
John Attia
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Nikola A Bowden
Nikola A Bowden
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, University Drive, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, University Drive, Newcastle, New South Wales, Australia
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Introduction Endometrial cancer is the most common gynaecological malignancy in women from developed countries ( 1 ), and breast cancer is the most common cancer that develops in women worldwide and is responsible for the most female cancer
Kirsty G Pringle
Kirsty G Pringle
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Sarah J Delforce
Sarah J Delforce
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Yu Wang
Yu Wang
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Katie A Ashton
Katie A Ashton
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Anthony Proietto
Anthony Proietto
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Geoffrey Otton
Geoffrey Otton
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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C Caroline Blackwell
C Caroline Blackwell
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Division of Molecular Medicine, Pathology North, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Division of Molecular Medicine, Pathology North, Newcastle, New South Wales, Australia
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Eugenie R Lumbers
Eugenie R Lumbers
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Introduction Endometrial cancer (EC) is the most common gynaecological malignancy and its incidence is increasing. Worldwide, 288,000 women were diagnosed with EC in 2008 ( www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/endometrial-cancer
Qi Che
Qi Che
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Xirong Xiao
Xirong Xiao
Department of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
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Jun Xu
Jun Xu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Miao Liu
Miao Liu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Yongning Lu
Yongning Lu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Suying Liu
Suying Liu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Xi Dong
Xi Dong
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Introduction Endometrial cancer is the fifth most common cancer in females (4.8% of cancers in women), who have a accumulative risk of 1% of developing the disease by age 75 years ( 1 ). Additionally, endometrial adenocarcinomas is separated
Yali Cheng
Yali Cheng
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Qiaoying Lv
Qiaoying Lv
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Bingying Xie
Bingying Xie
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Bingyi Yang
Bingyi Yang
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Weiwei Shan
Weiwei Shan
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Chengcheng Ning
Chengcheng Ning
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Bing Li
Bing Li
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Liying Xie
Liying Xie
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Chao Gu
Chao Gu
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Xuezhen Luo
Xuezhen Luo
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Xiaojun Chen
Xiaojun Chen
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Qin Zhu
Qin Zhu
Department of Pathology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, China
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Introduction Endometrial cancer (EC) is one of the most common malignant genital tumors among females worldwide, with an estimated 61,380 new cases in America in 2017 ( 1 ). It is known that type1 EC is estrogen-dependent tumor. Sustained
Keina Nishio
Keina Nishio
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan
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Akiko Tanabe
Akiko Tanabe
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan
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Risa Maruoka
Risa Maruoka
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan
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Kiyoko Nakamura
Kiyoko Nakamura
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan
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Masaaki Takai
Masaaki Takai
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan
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Tatsuharu Sekijima
Tatsuharu Sekijima
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan
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Satoshi Tunetoh
Satoshi Tunetoh
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan
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Yoshito Terai
Yoshito Terai
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan
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Masahide Ohmichi
Masahide Ohmichi
Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan
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Introduction Cancer survivors are living longer after the initial diagnosis of cancer due to earlier diagnosis and improved cancer treatments. Epithelial ovarian cancer (OC), uterine endometrial cancer (EC), and cervical cancer (CC) are major
Abdul K Siraj
Abdul K Siraj
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Rong Bu
Rong Bu
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Maham Arshad
Maham Arshad
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Kaleem Iqbal
Kaleem Iqbal
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Sandeep Kumar Parvathareddy
Sandeep Kumar Parvathareddy
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Tariq Masoodi
Tariq Masoodi
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Laila Omar Ghazwani
Laila Omar Ghazwani
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Saif S Al-Sobhi
Saif S Al-Sobhi
Department of Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Fouad Al-Dayel
Fouad Al-Dayel
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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Khawla S Al-Kuraya
Khawla S Al-Kuraya
Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
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identified germline pathogenic variants in the exonuclease domain of POLE and POLD1 which predispose, with a high penetrance, to multiple and/or large colorectal adenomas, early-onset colorectal cancer (CRC) as well as endometrial cancer in female
María J Gómora
María J Gómora
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Flavia Morales-Vásquez
Flavia Morales-Vásquez
Departamento de Oncología Médica, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, Mexico
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Enrique Pedernera
Enrique Pedernera
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Delia Perez-Montiel
Delia Perez-Montiel
Departamento de Patología, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, Mexico
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Horacio López-Basave
Horacio López-Basave
Departamento de Cirugía Oncológica, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, Mexico
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Antonio R Villa
Antonio R Villa
División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Azucena Hernández-Martínez
Azucena Hernández-Martínez
Hospital Militar de Especialidades de la Mujer y Neonatología, Secretaría de la Defensa Nacional, CdMx, Mexico
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Esteban Mena
Esteban Mena
Unidad de Apoyo Académico, Secretaría General, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Carmen Mendez
Carmen Mendez
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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several malignancies such as breast and endometrial cancer ( 15 ). Previous studies have reported an association between the expression of steroid receptors and the progression of ovarian cancer ( 16 , 17 , 18 ); however, more evidence is required to
Victoria Chatzimavridou-Grigoriadou
Victoria Chatzimavridou-Grigoriadou
Department of Endocrinology, Christie Hospital NHS Foundation Trust, Manchester, UK
Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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Lisa H Barraclough
Lisa H Barraclough
Department of Endocrinology, Christie Hospital NHS Foundation Trust, Manchester, UK
Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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Rohit Kochhar
Rohit Kochhar
Department of Clinical Oncology, Christie Hospital NHS Foundation Trust, Manchester, UK
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Lucy Buckley
Lucy Buckley
Department of Radiology, Christie Hospital NHS Foundation Trust, Manchester, UK
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Nooreen Alam
Nooreen Alam
Department of Radiotherapy, Christie Hospital NHS Foundation Trust, Manchester, UK
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Claire E Higham
Claire E Higham
Department of Endocrinology, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
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factor in previous studies. Given though that obesity is a known risk factor for endometrial cancer ( 24 ), one of the most common gynaecological malignancies, and the deleterious effects it has been shown to have on the bone ( 25 , 26 ), further studies
Joanna Klubo-Gwiezdzinska
Joanna Klubo-Gwiezdzinska
National Institute of Health, NIDDK, Office 10 Center Drive, Bethesda, Maryland, USA
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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John Costello Jr
John Costello Jr
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Kirk Jensen
Kirk Jensen
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Aneeta Patel
Aneeta Patel
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Rok Tkavc
Rok Tkavc
Department of Pathology, Uniformed Services University of the Health Sciences, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
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Douglas Van Nostrand
Douglas Van Nostrand
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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Kenneth D Burman
Kenneth D Burman
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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Leonard Wartofsky
Leonard Wartofsky
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA
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Vasyl Vasko
Vasyl Vasko
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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responsible for differential response to amifostine between normal and cancer cells in vivo ( 20 ). Luo and coworkers documented that sensitivity of endometrial cancer cells to the therapeutic effect of paclitaxel in combination with amifostine was dependent
