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André Marques-Pinto and Davide Carvalho

able to disrupt the closed feedback loops of the hormonal and homeostatic systems, thus being named endocrine disruptors (EDs) (7) . The group of known ED is extremely heterogeneous. It embraces ubiquitous synthetic substances used as industrial

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M Axelstad, U Hass, M Scholze, S Christiansen, A Kortenkamp and J Boberg

certain endocrine-disrupting chemicals (EDCs). Numerous EDCs are present in our environment, and EDCs are suspected of playing a role in testicular dysgenesis syndrome (TDS) in humans. This syndrome encompasses a range of male disorders, presumed to have

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Shane M Regnier, Andrew G Kirkley, Daniel Ruiz, Wakanene Kamau, Qian Wu, Kurunthachalam Kannan and Robert M Sargis

in a diet enriched in saturated and trans fats as well as simple carbohydrates that promote the development of obesity and diabetes ( 7 , 8 ). Recently, exposures to endocrine-disrupting chemicals (EDCs) have been implicated as novel metabolic

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Kylie D Rock, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather M Stapleton and Heather B Patisaul

similarities with known neurotoxicants and endocrine-disrupting chemicals (EDCs), including PBDEs ( 9 ) and organophosphate pesticides ( 10 ), have raised concerns regarding possible health impacts, especially on the developing brain. Because we have found

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Bilal B Mughal, Jean-Baptiste Fini and Barbara A Demeneix

-disrupting chemicals in the maternal and fetal environment. Endocrine-disrupting compounds (EDCs) are xenobiotics that modulate hormonal homeostasis thereby inducing adverse effects ( 8 ). Numerous EDCs identified to date contain a halogen group substitution with

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M Krause, H Frederiksen, K Sundberg, F S Jørgensen, L N Jensen, P Nørgaard, C Jørgensen, P Ertberg, J H Petersen, U Feldt-Rasmussen, A Juul, K T Drzewiecki, N E Skakkebaek and A M Andersson

prevalent human exposure to UV filters is of concern as several of these chemicals have endocrine-disrupting properties demonstrated in in vitro animal and human studies ( 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ). We recently investigated the

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Maurício Martins da Silva, Lueni Lopes Felix Xavier, Carlos Frederico Lima Gonçalves, Ana Paula Santos-Silva, Francisca Diana Paiva-Melo, Mariana Lopes de Freitas, Rodrigo Soares Fortunato, Leandro Miranda-Alves and Andrea Claudia Freitas Ferreira

). BPA is an endocrine disruptor, being considered a selective estrogen receptor modulator (SERM) ( 4 , 5 ), with important effects on reproductive function ( 4 , 6 ). Besides that, BPA was shown to have positive association with serum TSH ( 7 ) and

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Josef Köhrle

) Endocrinology of the Nervous System and Behaviour; and (3) Endocrine-Disrupting Chemicals. The journal will now contain these three independent sections aiming to provide a home for the excellent work published in these fields. These sections will be championed

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A Rehfeld, D L Egeberg, K Almstrup, J H Petersen, S Dissing and N E Skakkebæk

Introduction Human male infertility is a common problem worldwide ( 1 ). The causes are in many cases unknown, but exposure to endocrine disrupting chemicals (EDCs) has been suspected to be involved ( 2 , 3 ). Sperm cell dysfunction is a

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Konstantin Yakimchuk, Chandrashekar Bangalore Revanna, Dan Huang, Jose Inzunza and Sam Okret

considered as endocrine-related malignancies. In addition to the endogenous estrogenic ligands, estrogen signaling may be influenced by environmental synthetic or natural (dietary) xenoestrogens, so-called endocrine-disrupting chemicals (EDCs). An