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Shane M Regnier, Andrew G Kirkley, Daniel Ruiz, Wakanene Kamau, Qian Wu, Kurunthachalam Kannan and Robert M Sargis

in a diet enriched in saturated and trans fats as well as simple carbohydrates that promote the development of obesity and diabetes ( 7 , 8 ). Recently, exposures to endocrine-disrupting chemicals (EDCs) have been implicated as novel metabolic

Open access

Jana Ernst, Urszula Grabiec, Kathrin Falk, Faramarz Dehghani and Kristina Schaedlich

was found for an adverse impact on human health due to environmental agents, such as phthalates ( 6 ). Di-(2-ethylhexyl)-phthalate (DEHP) has belonged to the most abundant phthalates in industry and consumer goods for many years acting as an endocrine-disrupting

Open access

André Marques-Pinto and Davide Carvalho

able to disrupt the closed feedback loops of the hormonal and homeostatic systems, thus being named endocrine disruptors (EDs) (7) . The group of known ED is extremely heterogeneous. It embraces ubiquitous synthetic substances used as industrial

Open access

M Axelstad, U Hass, M Scholze, S Christiansen, A Kortenkamp and J Boberg

certain endocrine-disrupting chemicals (EDCs). Numerous EDCs are present in our environment, and EDCs are suspected of playing a role in testicular dysgenesis syndrome (TDS) in humans. This syndrome encompasses a range of male disorders, presumed to have

Open access

Rosalie Cabry, Philippe Merviel, Aicha Madkour, Elodie Lefranc, Florence Scheffler, Rachel Desailloud, Veronique Bach and Moncef Benkhalifa

The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men, and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (i) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects, and poor IVF outcomes, and (ii) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates and elevated risk of miscarriage associated with exposure to high doses of pesticides.

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Maurício Martins da Silva, Lueni Lopes Felix Xavier, Carlos Frederico Lima Gonçalves, Ana Paula Santos-Silva, Francisca Diana Paiva-Melo, Mariana Lopes de Freitas, Rodrigo Soares Fortunato, Leandro Miranda-Alves and Andrea Claudia Freitas Ferreira

). BPA is an endocrine disruptor, being considered a selective estrogen receptor modulator (SERM) ( 4 , 5 ), with important effects on reproductive function ( 4 , 6 ). Besides that, BPA was shown to have positive association with serum TSH ( 7 ) and

Open access

Kylie D Rock, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather M Stapleton and Heather B Patisaul

similarities with known neurotoxicants and endocrine-disrupting chemicals (EDCs), including PBDEs ( 9 ) and organophosphate pesticides ( 10 ), have raised concerns regarding possible health impacts, especially on the developing brain. Because we have found

Open access

M Krause, H Frederiksen, K Sundberg, F S Jørgensen, L N Jensen, P Nørgaard, C Jørgensen, P Ertberg, J H Petersen, U Feldt-Rasmussen, A Juul, K T Drzewiecki, N E Skakkebaek and A M Andersson

prevalent human exposure to UV filters is of concern as several of these chemicals have endocrine-disrupting properties demonstrated in in vitro animal and human studies ( 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ). We recently investigated the

Open access

Josef Köhrle

) Endocrinology of the Nervous System and Behaviour; and (3) Endocrine-Disrupting Chemicals. The journal will now contain these three independent sections aiming to provide a home for the excellent work published in these fields. These sections will be championed

Open access

A Rehfeld, D L Egeberg, K Almstrup, J H Petersen, S Dissing and N E Skakkebæk

Introduction Human male infertility is a common problem worldwide ( 1 ). The causes are in many cases unknown, but exposure to endocrine disrupting chemicals (EDCs) has been suspected to be involved ( 2 , 3 ). Sperm cell dysfunction is a