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Jana Ernst, Urszula Grabiec, Kathrin Falk, Faramarz Dehghani and Kristina Schaedlich

metabolism and endocrine homeostasis involve complex regulatory systems – among them is the endocannabinoid system (ECS). Endocannabinoids are endogenous ligands of the G-protein-coupled cannabinoid receptors, imitating several effects of the pharmacological

Open access

Anna C Simcocks, Kayte A Jenkin, Lannie O’Keefe, Chrishan S Samuel, Michael L Mathai, Andrew J McAinch and Deanne H Hryciw

comorbidities is the endocannabinoid system ( 3 ). In obesity, the endogenous endocannabinoid anandamide (AEA) promotes appetite and reduces energy expenditure through the activation of cannabinoid receptor 1 (CB 1 ) ( 4 ). AEA and tetrahydrocannabinol (THC