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Zi-Di Xu, Wei Zhang, Min Liu, Huan-Min Wang, Pei-Pei Hui, Xue-Jun Liang, Jie Yan, Yu-Jun Wu, Yan-Mei Sang, Cheng Zhu and Gui-Chen Ni

of CHI patients with different mutations are diverse ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 34 ). Diazoxide, a K ATP channel opener, is the first-line treatment for long-term treatment. In case of the diazoxide-unresponsive patient or

Open access

Benjamin G Challis, Andrew S Powlson, Ruth T Casey, Carla Pearson, Brian Y Lam, Marcella Ma, Deborah Pitfield, Giles S H Yeo, Edmund Godfrey, Heok K Cheow, V Krishna Chatterjee, Nicholas R Carroll, Ashley Shaw, John R Buscombe and Helen L Simpson

realised with supplementary carbohydrates alone. Refractory hypoglycaemia may be successfully treated with adjunctive therapeutics including diazoxide, somatostatin analogues or mammalian target of rapamycin (mTOR) inhibitors ( 4 , 5 ). Although these

Open access

R Solomon-Zemler, L Basel-Vanagaite, D Steier, S Yakar, E Mel, M Phillip, L Bazak, D Bercovich, H Werner and L de Vries

hypoglycemic events occurred day and night and persisted despite frequent feedings with carbohydrate-enriched meals and Proglycem (diazoxide) treatment. A percutaneous feeding gastrostomy was also inserted as the gastro-esophageal reflux was associated with

Open access

Aldo Bonaventura, Fabrizio Montecucco and Franco Dallegri

Journal of Physiology 1990 415 479 – 483 . ( doi:10.1007/BF00373626 ). 92 George PS Tavendale R Palmer CN McCrimmon RJ . Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes

Open access

Sara Ullsten, Sara Bohman, Marie E Oskarsson, K Peter R Nilsson, Gunilla T Westermark and Per-Ola Carlsson

chloride, leucine, tolbutamide, glutamine or alpha-ketoisocaproic acid also induce amyloid in cultured islets (17, 18). On the other hand, substances that decrease IAPP secretion like diazoxide or somatostatin limited amyloid deposit formation ( 18 ). In