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Monia Cito Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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Silvia Pellegrini Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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Lorenzo Piemonti Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
Vita-Salute San Raffaele University, Milan, Italy

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Valeria Sordi Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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Introduction Type 1 diabetes (T1D) is an autoimmune disorder characterized by insulin-producing β cell death caused by autoreactive T cells ( 1 ). T1D contributes to 10% of the total 422 million diabetes cases worldwide. Although T1D is no

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Ann-Kristin Picke Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany

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Graeme Campbell Institute of Biomechanics, TUHH Hamburg University of Technology, Hamburg, Germany

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Nicola Napoli Diabetes and Bone Network, Department Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Rome, Italy
Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, Missouri, USA

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Lorenz C Hofbauer Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany

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Martina Rauner Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany

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Introduction The prevalence of diabetes mellitus is increasing worldwide with diabetes-related complications accounting for up to 60–70% of health-care costs related to diabetes ( 1 , 2 ). Besides the well-known renal and cardiovascular

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Clemens Kamrath Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany

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Alexander Eckert German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany
Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany

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Birgit Rami-Merhar Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Vienna, Austria

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Sebastian Kummer Department of General Pediatrics, Neonatology and Pediatric Cardiology, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany

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Martin Wabitsch Center for Rare Endocrine Diseases, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Centre, Ulm, Germany

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Katharina Laubner Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany

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Florian Kopp Forth Clinical Department of Medicine, Academic Teaching Hospital Augsburg, Augsburg, Germany

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Silvia Müther Center for Pediatric Diabetology, DRK-Kliniken-Berlin Westend, Berlin, Germany

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Steffen Mühldorfer Department for Gastroenterology, Endocrinology and Metabolic Diseases, Bayreuth University Hospital, Friedrich-Alexander University Erlangen-Nuremberg, Bayreuth, Germany

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Reinhard W Holl German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany
Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany

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Introduction Diabetes mellitus due to insulin resistance is among the most prevalent endocrine disorders. It is commonly associated with obesity and lifestyle factors but may also occur in a very rare and severe form in patients with defects

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Mohamed Asrih Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland

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Flore Sinturel Thoracic and Endocrine Surgery Division, Department of Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Richard Dubos Department and Division of Primary Care Medicine, Geneva University Hospitals (HUG), Geneva, Switzerland

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Idris Guessous Department and Division of Primary Care Medicine, Geneva University Hospitals (HUG), Geneva, Switzerland

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Zoltan Pataky Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Charna Dibner Thoracic and Endocrine Surgery Division, Department of Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Karim Gariani Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Introduction Obesity is rapidly increasing worldwide despite it being a major health concern ( 1 ). Excess weight represents a hazardous condition leading to the development of type 2 diabetes (T2D) and its complications, mainly cardiovascular

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Lisa Arnetz Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes

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Neda Rajamand Ekberg Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes

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Kerstin Brismar Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes

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Michael Alvarsson Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes

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Introduction Along with progressive β-cell failure and insulin resistance, patients with type 2 diabetes (T2D) display disturbed regulation of cortisol and insulin-like growth factor 1 (IGF1) secretion (1) . Especially regarding the hypothalamus

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Marie Auzanneau Institute of Epidemiology and Medical Biometry, ZIBMT, Medical Faculty of Ulm University, Ulm, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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Alexander J Eckert Institute of Epidemiology and Medical Biometry, ZIBMT, Medical Faculty of Ulm University, Ulm, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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Andreas Fritsche German Center for Diabetes Research (DZD), Neuherberg, Germany
Department of Internal Medicine IV, University Hospital Tübingen, Germany
Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany

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Martin Heni Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
Division of Endocrinology and Diabetology, Department of Internal Medicine 1, University Hospital Ulm, Ulm, Germany
Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Tübingen, Germany

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Andrea Icks German Center for Diabetes Research (DZD), Neuherberg, Germany
Institute of Health Services Research and Health Economics, Center for Health and Society, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Institute of Health Services Research and Health Economics, German Diabetes Center (DDZ), Leibniz Centre for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

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Annabel S Mueller-Stierlin Department of General Practice and Primary Care, University Hospital Ulm, Um, Germany
Department of Psychiatry and Psychotherapy II, University Hospital Ulm, Um, Germany

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Ana Dugic Department of Gastroenterology, Klinikum Bayreuth, Medizincampus Oberfranken der Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Bayreuth, Germany

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Alexander Risse Diabetes Center at Sophie-Charlotte-Platz, Diabetes Foot Unit, Berlin, Germany

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Stefanie Lanzinger Institute of Epidemiology and Medical Biometry, ZIBMT, Medical Faculty of Ulm University, Ulm, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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Reinhard W Holl Institute of Epidemiology and Medical Biometry, ZIBMT, Medical Faculty of Ulm University, Ulm, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany

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Introduction The prevalence of diabetes is increasing worldwide ( 1 ). The number of people with diabetes in Germany, which has been recently estimated as 6.2 million (about 10%) ( 2 ), is expected to reach more than 10 million people by 2040

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Raymond J Rodgers Robinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia

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Jodie C Avery Robinson Research Institute, School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia

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Vivienne M Moore Robinson Research Institute, School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia

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Michael J Davies Robinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia

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Ricardo Azziz Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Elisabet Stener-Victorin Department of Physiology and Pharmacology Karolinska Institutet, Stockholm, Sweden

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Lisa J Moran Robinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia

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Sarah A Robertson Robinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia

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Nigel K Stepto Institute for Health and Sport, Victoria University, Melbourne, Australia

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Robert J Norman Robinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia
FertilitySA, Adelaide, South Australia, Australia

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Helena J Teede Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia

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associated risk of gestational diabetes (GDM), impaired glucose tolerance, type 2 diabetes (DM2), non-alcoholic fatty liver disease (NAFLD), dyslipidaemia and increased risk factors for both cerebrovascular and cardiovascular disease ( 6 , 7 , 8 , 9

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Hoda Gad Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Einas Elgassim Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Ibrahim Mohammed Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
Department of Internal Medicine, Albany Medical Center Hospital, Albany, New York, USA

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Ahmad Yaser Alhaddad Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar

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Hussein Ahmed Hussein Zaky Aly KINDI Center for computing research, Qatar University, Doha, Qatar

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John-John Cabibihan Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar

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Abdulaziz Al-Ali KINDI Center for computing research, Qatar University, Doha, Qatar

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Kishor Kumar Sadasivuni Center for Advanced Materials, Qatar University, Doha, Qatar

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Aliyaa Haji Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Neila Lamine Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Adnan Khan Faculty of Healthy Sciences, Khyber Medical University, Peshawar, Pakistan

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Ioannis N Petropoulos Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Georgios Ponirakis Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar

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Alise Kalteniece Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK

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Maryam Ferdousi Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK

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Shazli Azmi Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK

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Uazman Alam Diabetes and Neuropathy Research, Department of Eye and Vision Sciences and Pain Research Institute, Institute of Ageing and Chronic Disease, University of Liverpool and Aintree University Hospital NHS Foundation Trust, Liverpool, UK
Department of Diabetes and Endocrinology, Royal Liverpool and Broadgreen University NHS Hospital Trust, Liverpool, UK
Division of Endocrinology, Diabetes and Gastroenterology, University of Manchester, Manchester, UK

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Wajeeha Abuhelaiqa Hamad Medical Corporation, National Diabetes Center, Doha, Qatar

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Amin Jayyousi Hamad Medical Corporation, National Diabetes Center, Doha, Qatar

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Dabia AlMohanadi Hamad Medical Corporation, National Diabetes Center, Doha, Qatar

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Khaled Baagar Hamad Medical Corporation, National Diabetes Center, Doha, Qatar

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Rayaz A Malik Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK

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Introduction Diabetic peripheral neuropathy (DPN) affects ~50% of people with diabetes mellitus (T1DM) and (T2DM) ( 1 , 2 ). It has an insidious onset, which can lead to painful diabetic neuropathy, erectile dysfunction, foot ulceration and

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Xun Gong Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Lili You Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Feng Li Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Qingyu Chen Department of Medical Examination Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China

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Chaogang Chen Department of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China

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Xiaoyun Zhang Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Xiuwei Zhang Department of Endocrinology, Dongguan People’s Hospital, Dongguan, People’s Republic of China

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Wenting Xuan Department of Endocrinology, Dongguan People’s Hospital, Dongguan, People’s Republic of China

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Kan Sun Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Guojuan Lao Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Chuan Wang Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Yan Li Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Mingtong Xu Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Meng Ren Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Li Yan Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Introduction Diabetes mellitus is a global public health issue that causes huge economic and medical burdens worldwide. The prevalence of diabetes has increased over the past few decades, especially in Asian population ( 1 ). A national cross

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Helga Schultz Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark

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Svend Aage Engelholm Department of Radiation Oncology, Rigshospitalet, Copenhagen, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Eva Harder Department of Oncology and Palliation, Nordsjællands Hospital, Hillerød, Denmark

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Ulrik Pedersen-Bjergaard Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Peter Lommer Kristensen Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark

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(MSCC) and brain tumours. Diabetes mellitus (DM) is a well-known metabolic side effect from treatment with glucocorticoids. The diabetogenic effect is mainly a result of insulin resistance in muscle and fatty tissue, increased production of glucose from

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